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Multiple Sclerosis clinical trials in Columbus, OH

7 studies for Multiple Sclerosis are looking for participants at sites in and around Columbus (within about 30 miles). Open a study to see who can join and how to contact the study team.

A Phase 2a Study of SUN-627 in Participants With Non-Active Secondary Progressive and Primary Progressive Multiple Sclerosis (SPMS/PPMS)

RecruitingPhase 2
  • Local Institution - Site 104, Columbus
Ages 18 to 70 · All sexes · Updated Sep 25, 2026 · NCT07840326

A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS)

RecruitingObservational study
  • TG Therapeutics Investigational Trial Site, Columbus
  • TG Therapeutics Investigational Trial Site, Columbus
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT06433752

Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO

RecruitingPhase 1
  • Ohio State University Comprehensive Cancer Center, Columbus
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT03816345

Non-inferiority Study of Frexalimab Subcutaneous Administration Compared to Intravenous Administration in Adult Participants With Multiple Sclerosis

RecruitingPhase 3
  • The Ohio State University- Site Number : 8400009, Columbus
  • The Boster Center for Multiple Sclerosis- Site Number : 8400006, Columbus
Ages 18 to 60 · All sexes · Updated Sep 15, 2026 · NCT07325292

RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses

RecruitingPhase 2
  • The Ohio State University, Department of Psychiatry, Columbus
Ages 18 to 80 · All sexes · Updated Sep 15, 2026 · NCT07002034

A Study to Evaluate the Efficacy, Safety and Tolerability of BMS-986368 in Participants With Multiple Sclerosis Spasticity

RecruitingPhase 2
  • Riverside Methodist Hospital, Columbus
Ages 18 to 70 · All sexes · Updated Sep 9, 2026 · NCT06782490

A Study to Assess the Safety and Clinical Activity of Azer-cel in Participants With B-cell Mediated Autoimmune Disorders

RecruitingPhase 1
  • TG Therapeutics Investigational Trial Site, Columbus
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06680037

About Multiple Sclerosis

Multiple sclerosis (MS) slows down or blocks messages between the brain and body. MS can be mild or severe. Learn about MS symptoms and treatment.

More about Multiple Sclerosis on MedlinePlus

Multiple Sclerosis trials in other cities

Other studies in Columbus

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.