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Multiple Sclerosis clinical trials in Boston, MA

14 studies for Multiple Sclerosis are looking for participants at sites in and around Boston (within about 30 miles). Open a study to see who can join and how to contact the study team.

A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS)

RecruitingObservational study
  • TG Therapeutics Investigational Trial Site, Boston
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT06433752

Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO

RecruitingPhase 1
  • Massachusetts General Hospital Cancer Center, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT03816345

RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses

RecruitingPhase 2
  • Dana Farber Cancer Institute, Boston
Ages 18 to 80 · All sexes · Updated Sep 15, 2026 · NCT07002034

Dalfampridine Combined With Physical Therapy for Mobility Impairment in Multiple Sclerosis

RecruitingPhase 3
  • MGH Institute of Health Professions, Boston
Ages 25 to 75 · All sexes · Updated Jul 20, 2026 · NCT06136728

Prevalence and Impact of Obstructive Sleep Apnea in Multiple Sclerosis

RecruitingObservational study
  • Beth Israel Deaconess Medical Center, Boston
Ages 18 and older · All sexes · Updated May 11, 2026 · NCT04603196

Care in Multiple Sclerosis (MS)

RecruitingObservational study
  • Massachusetts General Hospital, Boston
Ages 18 and older · All sexes · Updated May 5, 2026 · NCT07011914

Molecular Imaging of NET Using [C-11]MRB-PET in MS

RecruitingPhase 1/2Healthy volunteers welcome
  • Brigham MS Center, 60 Fenwood Road, Boston
Ages 18 to 60 · All sexes · Updated Feb 2, 2026 · NCT03207464

PET Brain Imaging in Multiple Sclerosis, Alzheimer's Disease, and Other Neurological and Neuropsychiatric Diseases

RecruitingPhase 1/2Healthy volunteers welcome
  • Brigham MS Center, 60 Fenwood Road, Boston
Ages 18 to 85 · All sexes · Updated Jan 28, 2026 · NCT02649985

Glucose Consumption in MS Using [F-18]FDG-PET

RecruitingPhase 4Healthy volunteers welcome
  • Brigham & Women's Hospital, Boston
Ages 18 to 70 · All sexes · Updated Jan 9, 2026 · NCT07087106

Assessment of Synaptic Density in MS

RecruitingEarly phase 1Healthy volunteers welcome
  • Brigham and Women's Hospital, Boston
Ages 18 to 60 · All sexes · Updated Jan 9, 2026 · NCT04634994

Efgartigimod for the Treatment of Acute Optic Neuritis

RecruitingPhase 2
  • Massachusetts Eye and Ear Infirmary, Boston
  • Massachusetts General Hospital, Boston
Ages 18 and older · All sexes · Updated Nov 10, 2025 · NCT06453694

Vascular Mechanisms, Functional Outcomes, & Exercise Among Persons With Multiple Sclerosis With Hypertension

Recruiting
  • UMass Boston, Boston
Ages 18 and older · All sexes · Updated Aug 22, 2025 · NCT06554340

Nasal Foralumab in Patients With Non-Active Secondary Progressive Multiple Sclerosis

RecruitingPhase 2
  • Brigham and Women's Hospital, Boston
Ages 18 to 75 · All sexes · Updated Jun 6, 2025 · NCT06890923

Investigating the Utility of Demyelination Tracer [18F]3F4AP in Controls and Multiple Sclerosis Subjects

RecruitingPhase 1Healthy volunteers welcome
  • Massachusetts General Hospital, Boston
Ages 18 to 65 · All sexes · Updated Feb 27, 2025 · NCT04699747

About Multiple Sclerosis

Multiple sclerosis (MS) slows down or blocks messages between the brain and body. MS can be mild or severe. Learn about MS symptoms and treatment.

More about Multiple Sclerosis on MedlinePlus

Multiple Sclerosis trials in other cities

Other studies in Boston

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.