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Sickle Cell Disease clinical trials in St. Louis, MO

12 studies for Sickle Cell Disease are looking for participants at sites in and around St. Louis (within about 30 miles). Open a study to see who can join and how to contact the study team.

A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease

RecruitingPhase 3
  • Washington University-St.Louis, St Louis
Ages 12 and older · All sexes · Updated Sep 17, 2026 · NCT06612268

Cerebrovascular Reactivity Measurements With High-Density Diffuse Optical Tomography

RecruitingHealthy volunteers welcome
  • Washington University in St. Louis, St Louis
Ages 6 to 70 · All sexes · Updated Aug 20, 2026 · NCT07776444

A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease

RecruitingPhase 1/2Healthy volunteers welcome
  • Local Institution - 0030, St Louis
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT06481306

ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders

RecruitingObservational study
  • The John Bouhasin Center for Children with Bleeding Disorders, St Louis
All ages · All sexes · Updated Aug 17, 2026 · NCT04398628

Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis

RecruitingPhase 2
  • St. Louis Children's Hospital, St Louis
Ages 12 and older · All sexes · Updated Aug 14, 2026 · NCT06699849

Gene Correction in Autologous CD34+ Hematopoietic Stem Cells (HbS to HbA) to Treat Severe Sickle Cell Disease

RecruitingPhase 1/2
  • Washington University, St Louis
Ages 12 to 50 · All sexes · Updated Jul 2, 2026 · NCT04819841

Comparing the Effectiveness of Matched Related Donor Hematopoietic Stem Cell Transplantation to Disease Modifying Therapy in Pediatric Patients With Sickle Cell Disease

RecruitingObservational study
  • Wahington Univ in St Louis (NT-DMT), St Louis
  • Washington University in St Louis (MRD-HCT), St Louis
Ages 3 to 20 · All sexes · Updated Jun 4, 2026 · NCT06941389

Let's Get REAL: Family Health Communication Tool in Pediatric Stem Cell Transplant and Cellular Therapy

Recruiting
  • Washington University School of Medicine, St Louis
Ages 8 and older · All sexes · Updated Jun 4, 2026 · NCT06689800

Reduced Intensity Conditioning and Familial HLA-Mismatched BMT for Non-Malignant Disorders

RecruitingPhase 1/2
  • Washington University School of Medicine, St Louis
1 Day – 21 Years · All sexes · Updated May 29, 2026 · NCT03128996

Delivering Patient-Facing Evidence-Based Guidelines Through mHealth to Adults With Sickle Cell Disease

Recruiting
  • Washington University St. Louis, St Louis
Ages 18 and older · All sexes · Updated Mar 23, 2026 · NCT06919224

A Long-term Follow-up Study in Patients Who Received BEAM-101

RecruitingObservational study
  • Washington University School of Medicine in St. Louis, St Louis
Ages 14 to 37 · All sexes · Updated Jan 28, 2026 · NCT07373639

Cerebral Oxygen Metabolism in Children

RecruitingHealthy volunteers welcome
  • Washington University of St. Louis, St Louis
Ages 3 to 50 · All sexes · Updated Sep 11, 2025 · NCT04157179

About Sickle Cell Disease

Sickle cell disease is a group of inherited disorders that affect your red blood cells. It can cause pain, anemia, and other problems. Learn about treatments.

More about Sickle Cell Disease on MedlinePlus

Sickle Cell Disease trials in other cities

Other studies in St. Louis

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.