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Sickle Cell Disease clinical trials in Houston, TX

10 studies for Sickle Cell Disease are looking for participants at sites in and around Houston (within about 30 miles). Open a study to see who can join and how to contact the study team.

A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)

RecruitingPhase 3
  • Texas Childrens Cancer and Hematology Center, Houston
  • U of TX Health Science Ct, Houston
Ages 12 to 100 · All sexes · Updated Sep 28, 2026 · NCT06439082

A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or Thalassaemia

RecruitingPhase 3
  • Texas Children's Hospital_Houston, Houston
  • UT Health University of Texas, Houston
Ages 2 and older · All sexes · Updated Sep 18, 2026 · NCT06609226

A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease

RecruitingPhase 3
  • UT Health University of Texas, Houston
Ages 12 and older · All sexes · Updated Sep 17, 2026 · NCT06612268

A Phase I/II Study of ITU512 in Healthy Participants and Patients With Sickle Cell Disease

RecruitingPhase 1/2Healthy volunteers welcome
  • UT Health Science Center, Houston
Ages 12 to 55 · All sexes · Updated Sep 9, 2026 · NCT06546670

ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders

RecruitingObservational study
  • Gulf States Hemophilia and Thrombophilia Center, Houston
  • Texas Children's Hemophilia & Thrombosis Center/Baylor College of Medicine, Houston
All ages · All sexes · Updated Aug 17, 2026 · NCT04398628

The Efficacy and Safety of Rilzabrutinib in Participants Aged 10 to 65 Years With Sickle-cell Disease

RecruitingPhase 3
  • Baylor College of Medicine- Site Number : 8400055, Houston
Ages 10 to 65 · All sexes · Updated Jul 29, 2026 · NCT06975865

Comparing the Effectiveness of Matched Related Donor Hematopoietic Stem Cell Transplantation to Disease Modifying Therapy in Pediatric Patients With Sickle Cell Disease

RecruitingObservational study
  • Texas Children's Hopsital (NT-DMT), Houston
  • Texas Children's Hospital (MRD-HCT), Houston
Ages 3 to 20 · All sexes · Updated Jun 4, 2026 · NCT06941389

Study of a Single Dose of a 21-valent Pneumococcal Conjugate Vaccine in Children and Adolescents With Sickle Cell Disease

RecruitingPhase 3
  • Site # 8400004, Houston
Ages 2 to 17 · All sexes · Updated Apr 15, 2026 · NCT07247188

Zinc Supplementation in Sickle Cell Disease: A Precursor to the Think Zinc for Bones Trial

RecruitingPhase 2
  • Baylor College of Medicine, Houston
Ages 15 to 40 · All sexes · Updated Mar 13, 2026 · NCT06260891

Recruitment and Engagement in Care to Impact Practice Enhancement (RECIPE) for Sickle Cell Disease

RecruitingObservational study
  • University of Texas at Houston, Houston
Ages 18 and older · All sexes · Updated Jun 22, 2025 · NCT06385886

About Sickle Cell Disease

Sickle cell disease is a group of inherited disorders that affect your red blood cells. It can cause pain, anemia, and other problems. Learn about treatments.

More about Sickle Cell Disease on MedlinePlus

Sickle Cell Disease trials in other cities

Other studies in Houston

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.