Home › Non-Small Cell Lung Cancer › Ohio › Cleveland
Non-Small Cell Lung Cancer clinical trials in Cleveland, OH
43 studies for Non-Small Cell Lung Cancer are looking for participants at sites in and around Cleveland (within about 30 miles). Open a study to see who can join and how to contact the study team.
Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →
Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])
RecruitingPhase 3
- MetroHealth Medical Center, Cleveland
- Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland
- Cleveland Clinic Foundation, Cleveland
- and 2 more
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
RecruitingPhase 1/2
- The Cleveland Clinic Taussig Cancer Center, Cleveland
A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
RecruitingPhase 1
- University Hospitals Cleveland Medical Center, Cleveland
Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
RecruitingPhase 1
- Exelixis Clinical Site #10, Cleveland
A Platform Study in Non-Small Cell Lung Cancer (NSCLC)
RecruitingPhase 1/2
- Research Site, Cleveland
A Study to Evaluate Pumitamig Versus Durvalumab Following Concurrent Chemoradiation Therapy in Participants With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) (ROSETTA Lung-201)
RecruitingPhase 3
- University Hospitals Cleveland Medical Center, Cleveland
- Cleveland Clinic, Cleveland
- Cleveland Clinic - Hillcrest Hospital, Mayfield Heights · 12 mi away
A Study to Learn About the Study Medicine Called PF-08046054/SGN-PDL1V Versus Docetaxel in Adult Participants With Previously-Treated Programmed Cell Death Ligand 1 (PD-L1) Positive Non-Small-Cell Lung Cancer (NSCLC)
RecruitingPhase 3
- University Hospitals Cleveland Medical Center, Cleveland
- UH Minoff Health Center at Chagrin Highlands, Orange · 12 mi away
- University Hospitals Seidman Cancer Center at UH Mentor Health Center, Mentor · 22 mi away
Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer
RecruitingPhase 3
- University Hospitals Cleveland Medical Center, Cleveland
This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.
RecruitingPhase 3
- University Hospitals Cleveland Medical Center, Cleveland
- UH Minoff Health Center at Chagrin Highlands, Orange · 12 mi away
- University Hospitals Seidman Cancer Center at UH Mentor Health Center, Mentor · 22 mi away
A Study of JNJ-90301900 in Combination With Chemoradiation Followed by Consolidation Immunotherapy for Non-Small Cell Lung Cancer (NSCLC)
RecruitingPhase 2
- University Hospitals Cleveland Medical Center, Cleveland
Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer
RecruitingPhase 3
- Fairview Hospital, Cleveland
- Cleveland Clinic, Cleveland
- Cleveland Clinic - Hillcrest Hospital, Mayfield Heights · 12 mi away
A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors
RecruitingPhase 1/2
- Cleveland Clinic, Cleveland
Neoadjuvant and Adjuvant Treatment in Resectable Non-small Cell Lung Cancer
RecruitingPhase 2
- Research Site, Cleveland
Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and Other Investigational Agents for Lung Cancer
RecruitingPhase 2/3
- The Cleveland Clinic Cancer Center At Fairview Hospital, Moll Pavilion, Cleveland
- Cleveland Clinic, Cleveland
- Cleveland Clinic - Hillcrest Hospital, Mayfield Heights · 12 mi away
Pulmonary Rehabilitation in Advanced Lung Cancer Survivors
RecruitingPhase 2
- University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center, Cleveland
Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)
RecruitingPhase 2/3
- University Hospitals Cleveland Medical Center, Cleveland
Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients With High PD-L1
RecruitingPhase 3
- Clinical Study Site, Cleveland
Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies
RecruitingPhase 1/2
- Cleveland Clinic, Cleveland
Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7
RecruitingPhase 2/3
- University Hospitals Cleveland Medical Center, Cleveland
ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation
RecruitingObservational study
- Cleveland Clinic, Cleveland
A Phase 1/1b Study of IAM1363 in HER2 Cancers
RecruitingPhase 1
- University Hospital Cleveland Medical Center, Cleveland
- Cleveland Clinic, Cleveland
Sotorasib in Combination With Trastuzumab Deruxtecan for the Treatment of Locally Advanced and Metastatic Non-small Cell Lung Cancer With a KRAS G12C Mutation
RecruitingPhase 1/2
- Case Western Reserve University, Cleveland
Open-label Study of BBO-8520 in Adult Subjects With KRASG12C Non-small Cell Lung Cancer
RecruitingPhase 1
- Cleveland Clinic, Cleveland
A Study to Evaluate KIN-2787 in Participants With BRAF and/or NRAS Mutation Positive Solid Tumors
RecruitingPhase 1
- Cleveland Clinic, Cleveland
A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors
RecruitingPhase 1/2
- Cleveland Clinic Taussig Cancer Center, Cleveland
A Clinical Study to Investigate the Efficacy and Safety of an Investigational Combination Therapy With BNT324 and BNT327 in Patients With Advanced Lung Cancer
RecruitingPhase 1/2
- Cleveland Clinic Taussig Cancer Institute Case Comprehensive Cancer Center, Cleveland
MOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors
RecruitingPhase 1
- Cleveland Clinic, Cleveland
A Phase 1 Study of LNCB74 in Advanced Solid Tumors
RecruitingPhase 1
- Cleveland Clinic Taussig Cancer Institute, Cleveland
A Clinical Trial to Test if an Investigational Combination Therapy With BNT326 and BNT327 is Safe and Potentially Beneficial for People With Advanced Non-small Cell Lung Cancer (NSCLC)
RecruitingPhase 1/2
- Cleveland Clinic Taussig Cancer Institute Case Comprehensive Cancer Center, Cleveland
Study Evaluating the Safety and Efficacy of HWK-007, a PTK7-directed Antibody Drug Conjugate in Participants With Advanced Solid Tumors
RecruitingPhase 1
- University Hospital - Cleveland Medical Center, Cleveland
Clinical Trial of N-803 Plus Tislelizumab or Prior Failed Immune Checkpoint Inhibitor and Docetaxel Versus Docetaxel Monotherapy in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Acquired Resistance to Immune Checkpoint In
RecruitingPhase 3
- University Hospitals Cleveland Medical Center, Cleveland
A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors
RecruitingPhase 1
- University Hospitals Cleveland Medical Center, Cleveland
Study of STK-012 Alone and With Other Treatments in Patients With Advanced Lung Cancer and Other Cancers
RecruitingPhase 1/2
- University Hospitals Cleveland, Cleveland
Study of RAS(ON) Inhibitors in Patients With Advanced RAS-mutated NSCLC
RecruitingPhase 1/2
- University Hospitals Cleveland Medical Center, Cleveland
First-in-Human Study of PLX-61639 in Locally Advanced or Metastatic Solid Tumors
RecruitingPhase 1
- Research Site, Cleveland
A Study to Find a Suitable Dose of ASP5834 in Adults With Solid Tumors
RecruitingPhase 1
- University Hospitals - UH Cleveland Medical Center, Cleveland
Phase 2 Study for the Patient, Who Has Diagnosed With Small Cell Lung Cancer (SCLC) or Non Small Cell Lung Cancer (NSCLC) or Renal Cell Carcinoma (RCC) and Finished the First Line Stand Treatment , Need More Treatment
RecruitingPhase 2
- Cleveland Clinic, Cleveland
A First-in-Human Study of CKD-703 in Advanced Solid Tumors and Non-Small Cell Lung Cancer
RecruitingPhase 1/2
- Gabrail Cancer Center, Ohio City · 1 mi away
Veterans Affairs Lung Cancer Surgery Or Stereotactic Radiotherapy
Recruiting
- Louis Stokes VA Medical Center, Cleveland, OH, Cleveland
Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors
RecruitingPhase 1/2
- Cleveland Clinic, Cleveland
SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
RecruitingObservational study
- Massive Bio SYNERGY-AI site, Mayfield Heights · 12 mi away
A Study Assessing KB707 for the Treatment of Advanced Solid Tumor Malignancies Affecting the Lungs
RecruitingPhase 1/2
- Cleveland Clinic, Cleveland
A Study to Assess the Efficacy of WSD0922-FU in Patients With C797S+ Advanced Non-small Cell Lung Cancer
RecruitingPhase 2
- Cleveland Clinic, Cleveland
Non-Small Cell Lung Cancer trials in other cities
- Houston, TX145 studies
- New York City, NY120 studies
- Arlington, VA104 studies
- Nashville, TN97 studies
- Boston, MA90 studies
- Los Angeles, CA87 studies
- St. Louis, MO73 studies
- Chicago, IL61 studies
- Baltimore, MD60 studies
- San Antonio, TX59 studies
- Columbus, OH56 studies
- Washington, DC55 studies
Other studies in Cleveland
- Cancer (all types)36 studies
- Breast Cancer35 studies
- Prostate Cancer34 studies
- Heart Failure33 studies
- Metastatic Cancer30 studies
- Ovarian Cancer30 studies
- Lung Cancer26 studies
- Colorectal Cancer24 studies
- Cardiovascular Disease22 studies
- Endometrial Cancer20 studies
- Acute Myeloid Leukemia20 studies
- Crohn's Disease19 studies
From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.