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Healthy volunteer studies in Columbia, MO

42 studies at sites in and around Columbia accept healthy volunteers — people without the condition being studied. Many studies pay participants for their time and travel; the amount is set by each study, so ask the study team.

Effects of Sirolimus on Asymptomatic ApoE4 Carriers

RecruitingPhase 1Healthy volunteers welcome
  • University of Missouri, Columbia
Ages 45 to 65 · Women · Updated Oct 5, 2026 · NCT07728175

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • MU Health - University Hospital/Ellis Fischel Cancer Center, Columbia
Ages 40 to 75 · All sexes · Updated Oct 2, 2026 · NCT05334069

Effects of Lean Beef Consumption on Cardiometabolic Health and Gut Microbiome

RecruitingHealthy volunteers welcome
  • University of Missouri-Columbia, Columbia
Ages 18 to 45 · All sexes · Updated Sep 25, 2026 · NCT06433115

Insomnia and Insulin Resistance

RecruitingHealthy volunteers welcome
  • University of Missouri, Columbia
Ages 18 to 50 · All sexes · Updated Sep 24, 2026 · NCT07333586

Sleep as a Mechanism of Change in Alcohol Use

RecruitingHealthy volunteers welcome
  • University of Missouri-Columbia, Columbia
Ages 18 to 49 · All sexes · Updated Sep 14, 2026 · NCT06286774

Beta3-adrenergic Receptors and Cardiovascular Function in Aging Women

RecruitingEarly phase 1Healthy volunteers welcome
  • University of Missouri, Columbia
Ages 18 to 70 · Women · Updated Sep 10, 2026 · NCT07674680

Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia

RecruitingEarly phase 1Healthy volunteers welcome
  • University of Missouri-Columbia, Columbia
Ages 18 to 70 · Women · Updated Sep 10, 2026 · NCT06417177

A Study to Learn About How a New Pneumococcal Vaccine Works in Infants.

RecruitingPhase 3Healthy volunteers welcome
  • University of Missouri Pediatrics Clinic-South Providence, Columbia
  • University of Missouri, Columbia
42 Days – 211 Days · All sexes · Updated Sep 8, 2026 · NCT07629440

Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

RecruitingPhase 4Healthy volunteers welcome
  • University of Missouri Health System, Columbia
Ages 75 and older · All sexes · Updated Sep 1, 2026 · NCT04262206

Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity (ATM)

RecruitingObservational studyHealthy volunteers welcome
  • University of Missouri School of Medicine, Columbia
Ages 18 to 70 · All sexes · Updated Aug 6, 2026 · NCT06571474

Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity

RecruitingHealthy volunteers welcome
  • University of Missouri School of Medicine, Columbia
Ages 18 to 70 · All sexes · Updated Aug 6, 2026 · NCT06335771

Routine Validation and Reproducibility Testing of Laboratory Measures and Research Techniques Used for Metabolism Research (VAL)

RecruitingObservational studyHealthy volunteers welcome
  • University of Missouri School of Medicine, Columbia
Ages 18 to 75 · All sexes · Updated Aug 4, 2026 · NCT06286761

Impact of Sleep Restriction on Blood Pressure Reactivity

RecruitingHealthy volunteers welcome
  • University of Missouri, Columbia
Ages 18 to 45 · All sexes · Updated Jul 28, 2026 · NCT07489417

Sex Disparities in Hypoxic Vasodilation and Impact of Obesity

RecruitingEarly phase 1Healthy volunteers welcome
  • University of Missouri, Columbia
Ages 18 to 45 · All sexes · Updated Jul 28, 2026 · NCT05219799

Web-based Cognitive Behavioral Treatment for Insomnia in Dementia Caregivers

RecruitingHealthy volunteers welcome
  • University of Missouri, Columbia
Ages 18 and older · All sexes · Updated Jun 15, 2026 · NCT04632628

A Study on the Immune Response and Safety of an Investigational Chickenpox Vaccine When Given to Healthy Children 12 to 15 Months of Age

RecruitingPhase 3Healthy volunteers welcome
  • GSK Investigational Site, Jefferson City · 27 mi away
12 Months – 15 Months · All sexes · Updated May 29, 2026 · NCT06740630

High Protein Diet and Atherosclerosis

RecruitingHealthy volunteers welcome
  • University of Missouri School of Medicine, Columbia
Ages 45 to 75 · All sexes · Updated May 11, 2026 · NCT05235464

Growth Hormone Resistance of Beta-cells A

RecruitingObservational studyHealthy volunteers welcome
  • University of Missouri School of Medicine, Columbia
Ages 18 to 45 · Women · Updated May 11, 2026 · NCT06571487

Growth Hormone Resistance of Beta-cells in People With a Family History of Type 2 Diabetes

RecruitingObservational studyHealthy volunteers welcome
  • University of Missouri School of Medicine, Columbia
Ages 18 to 59 · All sexes · Updated May 11, 2026 · NCT06571500

Animal and Plant Proteins and Glucose Metabolism

RecruitingHealthy volunteers welcome
  • University of Missouri School of Medicine, Columbia
Ages 21 to 70 · All sexes · Updated May 8, 2026 · NCT03994367

Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)

RecruitingObservational studyHealthy volunteers welcome
  • University of Missouri-Columbia, Columbia
Ages 18 to 100 · All sexes · Updated May 7, 2026 · NCT07083557

Effect of Drain Care on Infection Rate and Quality of Life in Implant-Based Breast Reconstruction.

RecruitingHealthy volunteers welcome
  • University of Missouri, Columbia
Ages 18 to 100 · Women · Updated May 5, 2026 · NCT05846438

Tumor Cell and DNA Detection in the Blood, Urine and Bone Marrow of Patients With Solid Cancers

RecruitingObservational studyHealthy volunteers welcome
  • Ellis Fischel Cancer Center, University of Missouri, Columbia
Ages 18 and older · All sexes · Updated May 1, 2026 · NCT02838836

Impact of Phenylalanine Elevations on Brain and Cognition in Adult PKU Carriers

RecruitingHealthy volunteers welcome
  • University of Missouri-Columbia, Columbia
Ages 18 to 60 · All sexes · Updated Mar 11, 2026 · NCT07220265

Effects of Whole-body Electrical Muscle Stimulation Exercise on Spinal Motoneuronal Activation in Older Adults

RecruitingHealthy volunteers welcome
  • NextGen Precision Health Building, Clinical and Translational Science Unit, Columbia
Ages 18 and older · All sexes · Updated Feb 17, 2026 · NCT06689618

Lipoprotein Kinetics in T1D

RecruitingHealthy volunteers welcome
  • University of Missouri School of Medicine, Columbia
Ages 18 to 45 · All sexes · Updated Feb 10, 2026 · NCT05179954

Empagliflozin Reversal of Arterial StiffnEss in Aging

RecruitingPhase 2/3Healthy volunteers welcome
  • University of Missouri, Columbia
Ages 60 to 80 · All sexes · Updated Feb 6, 2026 · NCT06506422

Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN)

RecruitingObservational studyHealthy volunteers welcome
  • University of Missouri - Columbia, Columbia
Up to age 99 · All sexes · Updated Jan 9, 2026 · NCT07329257

Early Neurovascular Adaptations in Aging Women

RecruitingEarly phase 1Healthy volunteers welcome
  • University of Missouri-Columbia, Columbia
Ages 18 to 70 · Women · Updated Nov 26, 2025 · NCT06520982

Brain Blood Flow and Lactate in Non-obese and Obese Subjects

RecruitingObservational studyHealthy volunteers welcome
  • University of Missouri, Columbia
Ages 18 to 45 · All sexes · Updated Nov 26, 2025 · NCT06791837

Arterial Destiffening Effects of SGLT2 Inhibition in Veterans With Obesity

RecruitingPhase 2Healthy volunteers welcome
  • Harry S. Truman Memorial, Columbia, MO, Columbia
Ages 30 to 60 · All sexes · Updated Nov 14, 2025 · NCT06745063

An fMRI Study of the Effects of Clavulanic Acid on Drug Addiction

RecruitingPhase 2Healthy volunteers welcome
  • University of Missouri - Columbia, Columbia
Ages 18 to 65 · All sexes · Updated Oct 28, 2025 · NCT03713424

CAT BITE Antibiotic Prophylaxis for the Hand/Forearm (CATBITE)

RecruitingPhase 4Healthy volunteers welcome
  • University of Missouri, Columbia
Ages 18 and older · All sexes · Updated Oct 15, 2025 · NCT05846399

Tumor Cell and DNA Detection in the Blood, Urine, and Bone Marrow

RecruitingObservational studyHealthy volunteers welcome
  • Harry S Truman Veterans Memorial Hospital, Columbia
Ages 18 and older · All sexes · Updated Oct 8, 2025 · NCT03551951

Sympathetic Vascular Transduction Across the Menopause Transition: Contributing Mechanisms

RecruitingEarly phase 1Healthy volunteers welcome
  • University of Missouri, Columbia
Ages 18 to 70 · Women · Updated Sep 15, 2025 · NCT06787066

Remote Sensing for ADRD-Specific Activities Identification in Older Adults

RecruitingHealthy volunteers welcome
  • University of Missouri, Columbia
Ages 50 and older · All sexes · Updated Aug 13, 2025 · NCT07120347

Dietary Fiber Effects on the Microbiome and Satiety

RecruitingHealthy volunteers welcome
  • University of Missouri-Columbia, Columbia
Ages 20 to 55 · All sexes · Updated Jun 22, 2025 · NCT04611217

Implementation Supports for Improving Identification and Delivery of School-based Mental Health Supports for Middle Schools Students

RecruitingHealthy volunteers welcome
  • University of Missouri, Columbia
Ages 10 to 99 · All sexes · Updated Jun 19, 2025 · NCT06047041

Outcomes Following Combined Adductoplasty™ and Lapiplasty® (MTA3D)

RecruitingHealthy volunteers welcome
  • JCMG - Jefferson City Medical Group, Jefferson City · 27 mi away
Ages 14 to 65 · All sexes · Updated May 25, 2025 · NCT05587569

Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Myasthenia Gravis

RecruitingHealthy volunteers welcome
  • NextGen Precision Health Building, Clinical and Translational Science Unit, Columbia
Ages 18 and older · All sexes · Updated Apr 10, 2025 · NCT06064695

Extending Dental Care to Nursing Home Residents to Reduce Mouth Infections and Incidence of Pneumonia and Improve Diabetic Glucose Control

RecruitingHealthy volunteers welcome
  • Office of Dental Health, Department of Health and Senior Services, Jefferson City · 27 mi away
Ages 60 to 100 · All sexes · Updated Mar 26, 2025 · NCT06890676

NeuroControl of Nicotine Dependence

RecruitingHealthy volunteers welcome
  • Health Neuroscience Center, Columbia
Ages 18 to 60 · All sexes · Updated Oct 1, 2024 · NCT06347055

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.