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Pancreatic Cancer clinical trials in Chicago, IL

20 studies for Pancreatic Cancer are looking for participants at sites in and around Chicago (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Study of AZD9574 as Monotherapy and in Combination With Anti-cancer Agents in Participants With Advanced Solid Malignancies

RecruitingPhase 1/2
  • Research Site, Chicago
Ages 18 to 130 · All sexes · Updated Oct 5, 2026 · NCT05417594

Atebimetinib + GnP as a First Line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma

RecruitingPhase 3
  • City of Hope, Chicago
Ages 18 and older · All sexes · Updated Oct 5, 2026 · NCT07562152

Testing the Safety and Tolerability of the Anti-cancer Drugs Trastuzumab Deruxtecan and Neratinib for Cancers With Changes in the HER2 Gene

RecruitingPhase 1
  • Northwestern University, Chicago
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT05372614

A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

RecruitingPhase 1
  • University of Chicago Hospital, Chicago
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06465069

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 2
  • University of Illinois Cancer Center, Chicago
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06172478

Study of Zoldonrasib + Chemo of Investigator's Choice vs Placebo + Chemo of Investigator's Choice as First-line Treatment in Metastatic KRAS G12D-mutated Pancreatic Adenocarcinoma ( RASolute 305 )

RecruitingPhase 3
  • University of Chicago Medical Center, Chicago
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07621718

A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma

RecruitingPhase 3
  • Investigative Site US079, Chicago
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07522073

CREO - Microwave Ablation Feasibility Study

Recruiting
  • Rush University Medical Center, Chicago
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT07817147

Comparing the Clinical Impact of Pancreatic Cyst Surveillance Programs and Associated Biomarkers

RecruitingObservational study
  • Northwestern University, Chicago
  • Advocate Illinois Masonic Medical Center, Chicago
Ages 50 to 75 · All sexes · Updated Sep 4, 2026 · NCT04239573

BMS-986504 in Combination With Pemetrexed for the Treatment of Metastatic Solid Tumors With MTAP Deletion

RecruitingPhase 1/2
  • Northwestern University, Chicago
Ages 18 and older · All sexes · Updated Aug 25, 2026 · NCT07594626

Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer

RecruitingPhase 3
  • Northwestern University, Chicago
  • University of Illinois, Chicago
  • Advocate Illinois Masonic Medical Center, Chicago
Ages 18 and older · All sexes · Updated Aug 25, 2026 · NCT06958328

Pancreatic Cancer Early Detection Consortium

RecruitingObservational studyHealthy volunteers welcome
  • University of Chicago Medicine, Chicago
Ages 18 to 90 · All sexes · Updated Jul 22, 2026 · NCT04970056

Safely Optimizing Body Weight With Mifomelatide (TCMCB07) in Patients With Newly Diagnosed Colorectal Cancer (CRC) or Pancreatic Ductal Adenocarcinoma (PDAC) Undergoing Chemotherapy

RecruitingPhase 2
  • Northwestern University - Robert H. Lurie Comprehensive Cancer Center, Chicago
Ages 18 and older · All sexes · Updated Jul 15, 2026 · NCT06937177

Study to Assess Adverse Events and Pharmacokinetics in Adult Participants With Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma and Other Solid Tumors, Receiving Intravenous Infusion of Azirkitug Alone or in Combination(s) With Budigalimab, Bevacizumab, or Telisotuzumab Adizutecan

RecruitingPhase 1
  • University of Illinois Hospital and Health Sciences System /ID# 251750, Chicago
  • University of Chicago Medical Center /ID# 276271, Chicago
Ages 18 and older · All sexes · Updated Jun 23, 2026 · NCT05005403

Lidocaine Infusion in Pancreatic Cancer

RecruitingEarly phase 1
  • University of Illnois at Chicago, Chicago
Ages 18 and older · All sexes · Updated Jun 15, 2026 · NCT04048278

Lanreotide Versus Placebo Before Surgery to Prevent a Surgical Complication Called a Pancreatic Fistula

RecruitingPhase 3
  • Northwestern University, Chicago
  • University of Illinois, Chicago
Ages 18 and older · All sexes · Updated Mar 31, 2026 · NCT06807437

A Phase II Nationwide, Fully Decentralized, Telemedicine Study of Pemigatinib in Adult Patients With Advanced or Metastatic Pancreatic Cancer With FGFR Genetic Alterations

RecruitingPhase 2
  • Ohio State University-Telemedicine, Chicago
Ages 18 and older · All sexes · Updated Feb 17, 2026 · NCT06906562

LOTUS-CC: An Observational Research Study to Uncover Subtypes of Cancer Cachexia

RecruitingObservational study
  • Advocate Illinois Masonic Medical Center, Chicago
Ages 18 and older · All sexes · Updated Jan 9, 2026 · NCT06073431

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Chicago
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

CPI-613 (Devimistat) in Combination With Hydroxychloroquine and 5-fluorouracil or Gemcitabine in Treating Patients With Advanced Chemorefractory Solid Tumors

RecruitingPhase 2
  • Northwestern University, Chicago
Ages 18 and older · All sexes · Updated Mar 10, 2023 · NCT05733000

About Pancreatic Cancer

The pancreas is a gland behind your stomach that produces insulin. Pancreatic cancer is hard to catch early. Find out about risk factors and symptoms.

More about Pancreatic Cancer on MedlinePlus

Pancreatic Cancer trials in other cities

Other studies in Chicago

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.