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Colorectal Cancer clinical trials in Orange, CA

16 studies for Colorectal Cancer are looking for participants at sites in and around Orange (within about 30 miles). Open a study to see who can join and how to contact the study team.

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Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, ERASur Trial

RecruitingPhase 2
  • UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT05673148

Testing the Addition of an Anti-Cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment (Capecitabine) for Metastatic or Unresectable Cancers

RecruitingPhase 1
  • UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT05803382

Testing the Addition of Anti-cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment, Cetuximab Plus Encorafenib, for Colorectal Cancer

RecruitingPhase 1
  • UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT06102902

A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer

RecruitingPhase 2/3
  • University of California, Irvine (UCI) Health - UC Irvine Medical Center, Orange
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07221357

Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

RecruitingPhase 1/2
  • UC IRVINE Health, Orange
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06128551

Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer

RecruitingPhase 3
  • Clinical Study Site, Orange
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT07228832

Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

RecruitingPhase 1/2
  • Children's Hospital of Orange County, Orange
12 Months – 30 Years · All sexes · Updated Aug 25, 2026 · NCT04851119

Testing the Addition of an Anti-Cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (5-Fluorouracil) for Metastatic, Refractory Colorectal Cancer

RecruitingPhase 1
  • UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange
Ages 18 and older · All sexes · Updated Jul 31, 2026 · NCT06654037

Testing the Combination of the Anti-Cancer Drugs Temozolomide and M1774 to Evaluate Their Safety and Effectiveness

RecruitingPhase 1/2
  • UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange
Ages 18 and older · All sexes · Updated Jul 31, 2026 · NCT05691491

Repurposing Riluzole for Cancer-Related Cognitive Impairment: A Pilot Trial

RecruitingPhase 2
  • Chao Family Comprehensive Cancer Center, University of California Irvine, Orange
Ages 18 and older · All sexes · Updated Jul 14, 2026 · NCT06580002

Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS

RecruitingPhase 1/2
  • UC Irvine/Chao Family Comprehensive Cancer Center, Orange
Ages 18 and older · All sexes · Updated May 15, 2026 · NCT05379985

Study of ctDNA Guided Change in Tx for Refractory Minimal Residual Disease in Colon Adenocarcinomas

RecruitingPhase 1
  • Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange
Ages 18 and older · All sexes · Updated May 11, 2026 · NCT04920032

TATE and Pembrolizumab (MK3475) in mCRC and NSCLC

RecruitingPhase 2
  • University of California, Irvine Medical Center, Orange
Ages 18 and older · All sexes · Updated Apr 16, 2026 · NCT04701476

Riluzole For Preventing Cognitive Dysfunction in Ca Pts Receiving Chemo (REFOCUS): Pilot Trial

RecruitingPhase 2
  • Chao Family Comprehensive Cancer Center, University of California Irvine, Orange
Ages 18 and older · All sexes · Updated Mar 3, 2026 · NCT07447050

64Cu-LNTH-1363S in Patients With Sarcoma or Gastrointestinal Tract Cancer

RecruitingPhase 1/2
  • UC Irvine Health - Chao Family Comprehensive Cancer Center, Orange
Ages 15 and older · All sexes · Updated Aug 12, 2025 · NCT06298916

About Colorectal Cancer

Colorectal cancer starts in the colon or rectum. It may not cause symptoms at first. Screening tests can help find it early, when treatment is most effective.

More about Colorectal Cancer on MedlinePlus

Colorectal Cancer trials in other cities

Other studies in Orange

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.