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Colorectal Cancer clinical trials in Washington, DC

29 studies for Colorectal Cancer are looking for participants at sites in and around Washington (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

The Vanguard Study: Testing a New Way to Screen for Cancer

RecruitingHealthy volunteers welcome
  • Walter Reed National Military Medical Center, Bethesda · 7 mi away
Ages 45 to 75 · All sexes · Updated Oct 5, 2026 · NCT06995898

Obtaining Solid Tumor Tissue From People Having Biopsy or Surgery for Certain Types of Cancer

RecruitingObservational study
  • National Institutes of Health Clinical Center, Bethesda · 7 mi away
Ages 2 and older · All sexes · Updated Oct 5, 2026 · NCT01915225

Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Cancer

RecruitingPhase 2
  • National Institutes of Health Clinical Center, Bethesda · 7 mi away
Ages 18 to 72 · All sexes · Updated Oct 2, 2026 · NCT01174121

Colonoscopy vs Stool Testing for Older Adults With Colon Polyps

Recruiting
  • MedStar Health, Washington D.C.
Ages 65 to 82 · All sexes · Updated Oct 2, 2026 · NCT05612347

Evaluation for NCI Surgery Branch Clinical Research Protocols

RecruitingObservational study
  • National Institutes of Health Clinical Center, Bethesda · 7 mi away
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT00001823

Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, ERASur Trial

RecruitingPhase 2
  • George Washington University Medical Center, Washington D.C.
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT05673148

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • MedStar Georgetown University Hospital, Washington D.C.
  • MedStar Washington Hospital Center, Washington D.C.
  • Walter Reed National Military Medical Center, Bethesda · 7 mi away
Ages 40 to 75 · All sexes · Updated Oct 2, 2026 · NCT05334069

PDS01ADC in Combination With Hepatic Artery Infusion Pump (HAIP) and Systemic Therapy for Subjects With Metastatic Colorectal Cancer, Intrahepatic Cholangiocarcinoma, or Metastatic Adrenocortical Carcinoma

RecruitingPhase 2
  • National Institutes of Health Clinical Center, Bethesda · 7 mi away
Ages 18 to 120 · All sexes · Updated Oct 1, 2026 · NCT05286814

Phase I/II Study of the Combination Immunotherapy Regimen: SX-682, TriAdeno Vaccine, Retifanlimab and IL-15 Agonist N-803 (STAR15) for Metastatic Colorectal Cancer (mCRC)

RecruitingPhase 1/2Mentions payment for participants
  • National Institutes of Health Clinical Center, Bethesda · 7 mi away
Ages 18 to 120 · All sexes · Updated Sep 28, 2026 · NCT06149481

A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A)

RecruitingPhase 1/2
  • Sibley Memorial Hospital ( Site 0310), Washington D.C.
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06428409

A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer

RecruitingPhase 3
  • Georgetown Univ Medical Center Lombardi Cancer Center, Washington D.C.
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06662786

A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer

RecruitingPhase 2/3
  • Maryland Oncology Hematology - Silver Spring, Silver Spring · 7 mi away
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07221357

Metarrestin (ML-246) in Subjects With Metastatic Solid Tumors

RecruitingPhase 1
  • National Institutes of Health Clinical Center, Bethesda · 7 mi away
Ages 12 to 120 · All sexes · Updated Sep 23, 2026 · NCT04222413

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

RecruitingPhase 1/2
  • Georgetown University Lombardi Cancer Center, Washington D.C.
  • Sibley Memorial Hospital, Washington D.C.
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT05786924

A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer

RecruitingPhase 3
  • George Washington University, Washington D.C.
  • Cancer Center For Blood Disorders A Division of American Oncology Partners P.A, Bethesda · 7 mi away
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT07284849

Colorectal Cancer Screening in the Homeless

Recruiting
  • George Washington University, Washington D.C.
Ages 45 to 75 · All sexes · Updated Sep 15, 2026 · NCT07220018

Testing the Effectiveness of the Anti-cancer Drug Pidnarulex (CX-5461), in Combination With Another Anti-cancer Drug Cemiplimab (REGN2810), in Treating Refractory Microsatellite Stable Colorectal Cancer

RecruitingPhase 1/2
  • MedStar Georgetown University Hospital, Washington D.C.
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT07147231

A Study of STRO-004 in Adults With Refractory/Recurrent Metastatic Cancer

RecruitingPhase 1
  • Georgetown University Medical Center, Washington D.C.
Ages 18 and older · All sexes · Updated Aug 27, 2026 · NCT07227168

Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

RecruitingPhase 1/2
  • Children's National Medical Center, Washington D.C.
12 Months – 30 Years · All sexes · Updated Aug 25, 2026 · NCT04851119

MOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors

RecruitingPhase 1
  • Sibley Memorial Hospital, Washington D.C.
Ages 18 and older · All sexes · Updated Aug 24, 2026 · NCT06586515

A Study of Novel Study Interventions and Combinations in Participants With Colorectal Cancer

RecruitingPhase 2
  • Research Site, Washington D.C.
Ages 18 to 130 · All sexes · Updated Aug 18, 2026 · NCT06792695

FOG-001 in Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2
  • Johns Hopkins University, Sibley Memorial Hospital, Washington D.C.
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT05919264

A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • National Institutes of Health, Bethesda · 7 mi away
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT05592626

Testing the Combination of the Anti-Cancer Drugs Temozolomide and M1774 to Evaluate Their Safety and Effectiveness

RecruitingPhase 1/2
  • National Cancer Institute Developmental Therapeutics Clinic, Bethesda · 7 mi away
Ages 18 and older · All sexes · Updated Jul 31, 2026 · NCT05691491

Cancer Experience Registry (CER) for Cancer Patients and Caregivers

RecruitingObservational studyHealthy volunteers welcome
  • Cancer Support Community Research & Training Institute, Washington D.C.
Ages 18 and older · All sexes · Updated Apr 23, 2026 · NCT02333604

LOTUS-CC: An Observational Research Study to Uncover Subtypes of Cancer Cachexia

RecruitingObservational study
  • MedStar Georgetown University Hospital, Washington D.C.
Ages 18 and older · All sexes · Updated Jan 9, 2026 · NCT06073431

Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer

RecruitingObservational study
  • MedStar Georgetown University Hospital, Washington D.C.
Ages 60 and older · All sexes · Updated Jan 8, 2026 · NCT03998202

Tempus CRC Surveillance Study: A ctDNA Biomarker Profiling Study of Patients With CRC Using NGS Assays

RecruitingObservational study
  • The Center for Cancer and Blood Disorders, Bethesda · 7 mi away
Ages 18 and older · All sexes · Updated May 6, 2025 · NCT05234177

About Colorectal Cancer

Colorectal cancer starts in the colon or rectum. It may not cause symptoms at first. Screening tests can help find it early, when treatment is most effective.

More about Colorectal Cancer on MedlinePlus

Colorectal Cancer trials in other cities

Other studies in Washington

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.