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Head and Neck Cancer clinical trials in Cleveland, OH

9 studies for Head and Neck Cancer are looking for participants at sites in and around Cleveland (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2
  • The Cleveland Clinic Taussig Cancer Center, Cleveland
Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750

FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC

RecruitingPhase 2/3
  • Site #0151, Cleveland
  • Site #0108, Cleveland
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06788990

First in Human Study of TUB-030 in Patients With Advanced Solid Tumors

RecruitingPhase 1/2
  • Cleveland Clinic, Cleveland
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT06657222

Tongue Proactive Strengthening Exercise Program Following Partial/Hemi Glossectomy and Reconstruction

Recruiting
  • Case Comprehensive Cancer Center, Cleveland Clinic Foundation, Cleveland
Ages 18 and older · All sexes · Updated Aug 6, 2026 · NCT07110142

Antibiotic Treatment Effects on Intratumoral Bacteria Modulation in Surgical Patients With Oral Cancer

RecruitingPhase 2
  • Case Comprehensive Cancer Center, Cleveland Clinic Foundation, Cleveland
Ages 18 and older · All sexes · Updated Aug 6, 2026 · NCT06627270

First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • UH Cleveland Medical Center, Cleveland
Ages 18 and older · All sexes · Updated Jul 7, 2026 · NCT05768139

cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

RecruitingObservational studyHealthy volunteers welcome
  • Cleveland Clinic, Cleveland
Ages 40 and older · All sexes · Updated Jan 20, 2026 · NCT05366881

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Mayfield Heights · 12 mi away
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors

RecruitingPhase 1
  • Cleveland Clinic, Cleveland
Ages 18 and older · All sexes · Updated Aug 15, 2025 · NCT04429542

About Head and Neck Cancer

Head and neck cancer includes cancers of the mouth, nose, sinuses, salivary glands, throat, and lymph nodes. Read the different symptoms of each type.

More about Head and Neck Cancer on MedlinePlus

Head and Neck Cancer trials in other cities

Other studies in Cleveland

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.