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Breast Cancer clinical trials in Lexington, KY

14 studies for Breast Cancer are looking for participants at sites in and around Lexington (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • CommonSpirit Saint Joseph Hospital - Lexington, Lexington
  • Saint Joseph Radiation Oncology Resource Center, Lexington
  • CommonSpirit Saint Joseph Medical Center - East Lexington, Lexington
Ages 40 to 75 · All sexes · Updated Oct 2, 2026 · NCT05334069

A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016)

RecruitingPhase 3
  • Baptist Health Lexington ( Site 0050), Lexington
  • Baptist Health Hamburg ( Site 0071), Lexington
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07060807

A Study of Imlunestrant (LY3484356) in Premenopausal Women With Estrogen Receptor-Positive (ER+) Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Early Breast Cancer

RecruitingPhase 2
  • University of Kentucky Chandler Medical Center, Lexington
Ages 18 and older · Women · Updated Sep 22, 2026 · NCT07287098

A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer

RecruitingPhase 3
  • Baptist Health Lexington, Lexington
  • Baptist Health Hamburg, Lexington
  • University of Kentucky - Markey Cancer Center, Lexington
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT06790693

Toci +/- SOC Chemo for Metastatic Triple Negative and ER-positive, HER2-negative Breast Cancers

RecruitingPhase 2
  • University of Kentucky-Lexington, Lexington
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT05846789

Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

RecruitingPhase 3
  • Baptist Health Lexington, Lexington
  • CommonSpirit Saint Joseph Hospital - Lexington, Lexington
  • Markey Cancer Center at Lexington Clinic, Lexington
  • and 4 more
Ages 18 to 60 · Women · Updated Sep 2, 2026 · NCT05879926

E-Mindfulness Approaches for Living After Breast Cancer

RecruitingPhase 3
  • CommonSpirit Saint Joseph Medical Center - East Lexington, Lexington
Ages 18 to 50 · All sexes · Updated Aug 4, 2026 · NCT06748222

EXoPERT EMERALD Clinical Study

RecruitingObservational studyHealthy volunteers welcome
  • Lexington VA Healthcare System, Lexington
Ages 45 and older · All sexes · Updated Jul 1, 2026 · NCT07186296

Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors

RecruitingPhase 1
  • UK Markey Cancer Center, Lexington
Ages 18 and older · All sexes · Updated Jun 11, 2026 · NCT05283330

De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

RecruitingPhase 3
  • Saint Joseph Hospital, Lexington
  • Saint Joseph Radiation Oncology Resource Center, Lexington
  • Saint Joseph Hospital East, Lexington
  • and 1 more
Ages 50 to 70 · All sexes · Updated Apr 23, 2026 · NCT04852887

Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

RecruitingObservational study
  • Saint Joseph Hospital East, Lexington
Ages 18 and older · All sexes · Updated Mar 17, 2026 · NCT06418204

A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

RecruitingPhase 1
  • University of Kentucky Markey Cancer Center, Lexington
Ages 18 and older · All sexes · Updated Feb 13, 2026 · NCT06778863

cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

RecruitingObservational studyHealthy volunteers welcome
  • Baptist Lexington, Lexington
Ages 40 and older · All sexes · Updated Jan 20, 2026 · NCT05366881

S1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk of Cardiac Toxicity

RecruitingPhase 3
  • Saint Joseph Hospital East, Lexington
Ages 18 and older · All sexes · Updated Oct 8, 2025 · NCT03418961

About Breast Cancer

Breast cancer is a cancer that starts in the breast tissue, when cells change and grow out of control. These extra cells can form a mass called a tumor.

More about Breast Cancer on MedlinePlus

Breast Cancer trials in other cities

Other studies in Lexington

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.