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Crohn's Disease clinical trials in Cleveland, OH

19 studies for Crohn's Disease are looking for participants at sites in and around Cleveland (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)

RecruitingPhase 3
  • Great Lakes Gastroenterology Research, LLC ( Site 5016), Mentor · 22 mi away
Ages 16 to 80 · All sexes · Updated Oct 2, 2026 · NCT06430801

Investigating the Effect of the Non-nutritive Sweetener Sucralose in Inflammatory Bowel Disease

RecruitingHealthy volunteers welcome
  • University Hospitals Cleveland Medical Center, Cleveland
  • UH Minoff Health Center, Chagrin Falls · 17 mi away
Ages 18 to 75 · All sexes · Updated Oct 1, 2026 · NCT07852273

A Study of Vedolizumab in Adults With Ulcerative Colitis (UC) or Crohn's Disease (CD) in the Community Setting

RecruitingPhase 4
  • Great Lakes Gastroenterology Research, LLC, Mentor · 22 mi away
Ages 18 to 80 · All sexes · Updated Sep 30, 2026 · NCT06581328

Non-nutritive Sweeteners in Inflammatory Bowel Disease

RecruitingHealthy volunteers welcome
  • University Hospitals Cleveland Medical Center, Cleveland
  • UH Minoff Health Center, Chagrin Falls · 17 mi away
Ages 18 to 70 · All sexes · Updated Sep 25, 2026 · NCT07769437

A Study of Guselkumab Versus Risankizumab in Participants With Moderately to Severely Active Crohn's Disease

RecruitingPhase 3
  • Great Lakes Gastroenterology Research, LLC, Mentor · 22 mi away
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07499232

A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Crohn's Disease

RecruitingPhase 2
  • Great Lakes Gastroenterology Research, LLC, Mentor · 22 mi away
Ages 18 to 75 · All sexes · Updated Sep 25, 2026 · NCT06233461

An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease

RecruitingPhase 3
  • University Hospitals Cleveland Medical Center-Site Number: 8400073, Cleveland
Ages 16 to 80 · All sexes · Updated Sep 23, 2026 · NCT07184931

A Study of Vedolizumab Intravenous (IV) and Adalimumab or Vedolizumab and Ustekinumab in Adults With Crohn's Disease

RecruitingPhase 4
  • Great Lakes Gastroenterology Research, LLC, Mentor · 22 mi away
Ages 18 to 70 · All sexes · Updated Sep 9, 2026 · NCT06045754

A Study of JNJ-78934804 in Participants With Moderately to Severely Active Crohn's Disease

RecruitingPhase 3
  • Great Lakes Gastroenterology Research, LLC, Mentor · 22 mi away
Ages 18 and older · All sexes · Updated Aug 28, 2026 · NCT07577843

Ultrasound-Guided Versus Standard Margin Selection in Ileocecal Resection of Terminal Ileal CD

Recruiting
  • Cleveland Clinic, Cleveland
Ages 18 and older · All sexes · Updated Aug 27, 2026 · NCT07680283

Crohn's Disease: Efficacy, Safety, and Pharmacokinetics of Upadacitinib in Pediatric Subjects With Moderately to Severely Active Crohn's Disease

RecruitingPhase 3
  • UH Cleveland Medical Center /ID# 262188, Cleveland
Ages 2 to 17 · All sexes · Updated Jun 24, 2026 · NCT06332534

A Long-Term Extension Study of Vedolizumab in Children and Teenagers With Ulcerative Colitis (UC) or Crohn's Disease (CD)

RecruitingPhase 3
  • University Children's Clinic, Cleveland
  • Cleveland Clinic, Cleveland
Ages 2 to 17 · All sexes · Updated Jun 22, 2026 · NCT06405087

Clinical, Imaging, and Endoscopic Outcomes of Children Newly Diagnosed With Crohn's Disease

RecruitingPhase 4
  • UH/Rainbow Babies and Children's Hospital, Cleveland
Ages 6 to 17 · All sexes · Updated May 27, 2026 · NCT05781152

A Study of Vedolizumab in Children With Ulcerative Colitis (UC) or Crohn's Disease (CD)

RecruitingPhase 3
  • University Hospitals Cleveland Medical Center - 11100 Euclid Ave, Cleveland
Ages 2 and older · All sexes · Updated May 7, 2026 · NCT05442567

Precise Infliximab Exposure and Pharmacodynamic Control

RecruitingPhase 2/3
  • Cleveland Clinic Children's Hospital, Cleveland
Ages 6 to 22 · All sexes · Updated May 5, 2026 · NCT05660746

A Study of Vedolizumab in Children and Teenagers With Moderate to Severe Crohn's Disease (CD)

RecruitingPhase 3
  • University Hospitals Cleveland Medical Center, Cleveland
Ages 2 to 17 · All sexes · Updated May 5, 2026 · NCT04779320

Treatment of Moderate to Severe Refractory Crohn's Disease

RecruitingPhase 1/2
  • Cleveland Clinic, Cleveland
Ages 18 to 65 · All sexes · Updated Dec 10, 2025 · NCT06721962

Development of a Novel Endoscopic Index and Patient-reported Outcome Measure for Clinical Trials in Participants With Permanent Ileostomy

RecruitingObservational study
  • Cleveland Clinic Foundation, Cleveland
Ages 18 and older · All sexes · Updated Nov 12, 2025 · NCT06670638

About Crohn's Disease

Crohn's Disease can cause inflammation in any area from the mouth to the anus. Read about medicines, surgery or dietary management to treat symptoms.

More about Crohn's Disease on MedlinePlus

Crohn's Disease trials in other cities

Other studies in Cleveland

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.