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Opioid Overdose clinical trials recruiting in the U.S.
179 studies for Opioid Overdose are recruiting participants at sites across the United States.
Opioid overdose leads to slowing or stopping of breathing and sometimes death. You can take steps to help prevent an overdose, and respond to one with naloxone.
Cities with the most studies
- Baltimore, MD18 studies
- New Haven, CT18 studies
- Philadelphia, PA15 studies
- Boston, MA12 studies
- New York City, NY12 studies
- Birmingham, AL7 studies
- Salt Lake City, UT7 studies
- Pittsburgh, PA7 studies
- Providence, RI6 studies
- San Francisco, CA6 studies
- Charleston, SC6 studies
- Indianapolis, IN5 studies
- Ann Arbor, MI5 studies
- Chicago, IL5 studies
- Minneapolis, MN5 studies
- Albuquerque, NM4 studies
- Edison, NJ4 studies
- Seattle, WA4 studies
- Durham, NC4 studies
- Columbus, OH4 studies
- Greenville, SC4 studies
- Morgantown, WV4 studies
- Portland, OR4 studies
- The Bronx, NY4 studies
- Washington, DC4 studies
- Springfield, MA3 studies
- Roanoke, VA3 studies
- Meads, KY3 studies
- Bridgeport, CT3 studies
- San Diego, CA3 studies
- Tampa, FL3 studies
- Nashville, TN3 studies
- Lexington, KY3 studies
- Atlanta, GA3 studies
- Oakland, CA3 studies
By state
- Alabama7 studies
- Arizona3 studies
- California18 studies
- Colorado3 studies
- Connecticut19 studies
- District of Columbia4 studies
- Florida6 studies
- Georgia3 studies
- Illinois6 studies
- Indiana6 studies
- Kentucky4 studies
- Maryland19 studies
- Massachusetts16 studies
- Michigan7 studies
- Minnesota8 studies
- New Jersey9 studies
- New Mexico5 studies
- New York16 studies
- North Carolina6 studies
- Ohio7 studies
- Oregon6 studies
- Pennsylvania25 studies
- Rhode Island7 studies
- South Carolina10 studies
- Tennessee3 studies
- Texas4 studies
- Utah7 studies
- Virginia4 studies
- Washington5 studies
- West Virginia6 studies
- Wisconsin4 studies
Recently updated studies
A Bundled Intervention to End Opioid Overdoses
RecruitingPhase 4
Ages 19 and older · All sexes · Updated Oct 2, 2026 · NCT07485335Characterization of CB1 Receptors Using [11-C]OMAR in Opioid Use Disorder
RecruitingPhase 1Healthy volunteers welcome
Ages 25 to 65 · All sexes · Updated Oct 2, 2026 · NCT07800520Outcome Inference in the Sensory Preconditioning Task in Opioid-Use Disorder
RecruitingObservational studyHealthy volunteers welcome
Ages 21 to 60 · All sexes · Updated Oct 2, 2026 · NCT03745339Buprenorphine Implementation at Syringe Service Programs to Reduce Overdoses
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT07631598Adjunctive Cannabidiol for Recovery From Opioid Study
RecruitingPhase 3
Ages 18 to 65 · All sexes · Updated Oct 1, 2026 · NCT06940674Sustaining Recovery for People on Opioid Agonist Treatment With Conversational Agents
Recruiting
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT06732596Sensing Physiological Symptoms of Opioid Withdrawal and Cravings in Patients With Opioid Use Disorder
RecruitingObservational study
Ages 18 to 50 · All sexes · Updated Sep 28, 2026 · NCT06487533Development of an mHealth Behavioral Sleep Medicine Intervention for Use During Medication Assisted Treatment for MOUD
Recruiting
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT06157840Adaptive Decision Support for Addiction Treatment (ADAPT) Serial Randomized Testing for Usability, Round 3
Recruiting
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07793383A Study of Brenipatide in Participants With Opioid Use Disorder
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Sep 22, 2026 · NCT07420283Teaching Health Resilience in a Hospital Setting: A Peer-led Intervention
Recruiting
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT06843213Clinical Decision Support to Increase Use of Medications for Opioid Use Disorder
RecruitingObservational studyHealthy volunteers welcome
Ages 12 to 89 · All sexes · Updated Sep 21, 2026 · NCT06526286A Clinical Trial of Telehealth Treatment for Opioid Use Disorders
Recruiting
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT07362082Study to Assess the Use of Tezampanel for Opioid Withdrawal Syndrome in Treatment-Seeking Patients With Opioid Use Disorder
RecruitingPhase 1
Ages 18 to 65 · All sexes · Updated Sep 17, 2026 · NCT06538558Kentucky Women's Justice Community Overdose Innovation Network - Phase II
RecruitingHealthy volunteers welcome
Ages 18 and older · Women · Updated Sep 16, 2026 · NCT07179614Opioid and Pain Treatment in Indigenous Communities (OPTIC) Trial
Recruiting
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT06565416Office-based Methadone Versus Buprenorphine to Address Retention in Medication for Opioid Use Disorder Treatment.
RecruitingPhase 4
Ages 18 to 99 · All sexes · Updated Sep 14, 2026 · NCT06323824A Study Comparing Oral Buprenorphine and Injectable Buprenorphine for the Treatment of Opioid Use Disorder
RecruitingPhase 4
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT04375033Building Social and Structural Connections for the Prevention of Opioid Use Disorder Among Youth Experiencing Homelessness
Recruiting
Ages 14 to 24 · All sexes · Updated Sep 10, 2026 · NCT06311838OMAR Opioid Use Disorder
RecruitingPhase 1Healthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT05683184Pilot Testing of the emPath Platform to Improve Medication for Opioid Use Disorder (MOUD) Linkage and Retention Among Adults With Opioid Use Disorder in Durham, North Carolina
Recruiting
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT07810322Using Facebook to Support Opioid Recovery Among American Indian Women
Recruiting
Ages 18 and older · Women · Updated Sep 4, 2026 · NCT05995886Deep Brain Stimulation Effects In Patients With Opioid Use Disorder
Recruiting
Ages 22 to 65 · All sexes · Updated Aug 31, 2026 · NCT04354077Ketamine for Opioid Use Disorder
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Aug 31, 2026 · NCT06943859GLP-1R Agonist Treatment for Opioid Use Disorder
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Aug 28, 2026 · NCT06548490From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.