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Liver Cancer (Hepatocellular Carcinoma) clinical trials in Irvine, CA

6 studies for Liver Cancer (Hepatocellular Carcinoma) are looking for participants at sites in and around Irvine (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Symbiotic-GI-13: A Study to Learn About Study Medicine Called PF-08634404 as a Single Treatment and Combination Treatment in Adult Participants With a Liver Cancer Called Hepatocellular Carcinoma, That is Too Advanced to be Removed by Surgery and May Have Spread to Other Parts of the Body.

RecruitingPhase 1/2
  • Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine
  • UCI Health - Irvine Infusion Pharmacy ACC, Irvine
  • UCI Health - Irvine, Irvine
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07227012

Visugromab, Nivolumab and Lenvatinib Compared to Double Placebo and Lenvatinib in Unresectable or Metastatic Hepatocellular Carcinoma Post Anti-PD-(L)1 Failure

RecruitingPhase 2
  • UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine
Ages 18 to 100 · All sexes · Updated Sep 23, 2026 · NCT07219459

Testing the Addition of an Anti-cancer Drug, Sapanisertib, to the Usual Chemotherapy Treatment (Cabozantinib) in Metastatic Liver Cell Cancer With a Change in Genes for the Protein β-Catenin, The SAPHIRE Trial

RecruitingPhase 1/2
  • UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT06811116

Testing Immunotherapy With or Without Stereotactic Body Radiation Therapy in Patients With Advanced Liver Cancer, HELIO-RT Trial

RecruitingPhase 3
  • UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT07166406

A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors

RecruitingPhase 1
  • Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine
Ages 18 and older · All sexes · Updated Jul 22, 2026 · NCT05208762

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Irvine
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

Liver Cancer (Hepatocellular Carcinoma) trials in other cities

Other studies in Irvine

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.