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Melanoma clinical trials in Durham, NC
21 studies for Melanoma are looking for participants at sites in and around Durham (within about 30 miles). Open a study to see who can join and how to contact the study team.
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Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
RecruitingObservational studyHealthy volunteers welcome
- Durham VA Medical Center, Durham
NeoAdjuvant, Spare-Adjuvant (NASA) in Stage IIIB-IV (M1a) Melanoma
RecruitingPhase 2
- Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
DESTINY-PANTUMOUR04
RecruitingObservational study
- Research Site, Durham
A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)
RecruitingPhase 3
- Duke Health System, Durham
Comparing the Effectiveness of Less Invasive Procedures With the Current Standard of Care for the Treatment of Older Adults With Early-Stage Melanoma
RecruitingPhase 3
- Duke University Medical Center, Durham
A Study of BMS-986504 Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5)
RecruitingPhase 2
- Local Institution - 0100, Durham
ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation
RecruitingObservational study
- UNC- Chapel Hill, Chapel Hill · 10 mi away
DOC1021 Dendritic Cell Immunotherapy for Refractory Melanoma
RecruitingPhase 1/2
- University of North Carolina, Chapel Hill · 10 mi away
A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors
RecruitingPhase 1/2
- Duke Cancer Institute, Durham
Project: Every Child for Younger Patients With Cancer
RecruitingObservational study
- Duke University Medical Center, Durham
- UNC Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
Ulixertinib/Palbociclib in Patients With Advanced Pancreatic and Other Solid Tumors
RecruitingPhase 1
- Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
A Feasibility Study Utilizing Immune Recall to Increase Response to Checkpoint Therapy
RecruitingPhase 1
- Duke University Medical Center, Durham
A Study to Investigate the Safety and Efficacy of IOV-3001 in Adults With Advanced Melanoma Who Will Receive Lifileucel
RecruitingPhase 1/2
- UNC Hospitals, The University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions
RecruitingPhase 1/2
- Duke University Medical Center, Durham
IL-17 Blockade to Decrease irAEs (REPLAY)
RecruitingPhase 1
- Duke University Health System, Durham
A First-In Human (FIH) Study to Find Out How Well REGN10597 Medicine Given Alone or in Combination With Cemiplimab Works in Adult Participants Who Have Cancer With Tumors That Have Spread in Their Body
RecruitingPhase 1/2
- University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
A Randomized, Phase 2/3 Study to Investigate the Efficacy and Safety of RP2 in Combination With Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients With Metastatic Uveal Melanoma
RecruitingPhase 2/3
- Duke University Medical Center, Durham
Efficacy of Daromun Neoadjuvant Intratumoral Treatment in Clinical Stage IIIB/C/D Melanoma Patients
RecruitingPhase 3
- Duke University Medical Center - Duke Cancer Center, Durham
SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
RecruitingObservational study
- Massive Bio SYNERGY-AI site, Chapel Hill · 10 mi away
Excision of Lymph Node Trial (EXCILYNT) (Mel69)
Recruiting
- Duke University Health System, Durham
Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma
Recruiting
- Duke University Medical Center, Durham
- University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
- University of North Carolina Hospitals - Hillsborough Campus, Hillsborough · 13 mi away
About Melanoma
Melanoma is the most serious type of skin cancer. Most have a black or black-blue area. Learn the 'ABCDE' of what to watch for and treatment options.
More about Melanoma on MedlinePlus
Melanoma trials in other cities
- Houston, TX59 studies
- New York City, NY38 studies
- Los Angeles, CA34 studies
- Nashville, TN33 studies
- Pittsburgh, PA31 studies
- Boston, MA26 studies
- Philadelphia, PA23 studies
- San Francisco, CA22 studies
- Atlanta, GA21 studies
- St. Louis, MO21 studies
- Columbus, OH21 studies
- Salt Lake City, UT21 studies
Other studies in Durham
- Breast Cancer63 studies
- Cancer (all types)58 studies
- Non-Small Cell Lung Cancer39 studies
- Multiple Myeloma37 studies
- Metastatic Cancer33 studies
- Acute Myeloid Leukemia33 studies
- Lung Cancer32 studies
- Prostate Cancer32 studies
- Colorectal Cancer28 studies
- Chronic Lymphocytic Leukemia27 studies
- Ovarian Cancer27 studies
- Heart Failure26 studies
From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.