Home › Non-Small Cell Lung Cancer › California › San Diego
Non-Small Cell Lung Cancer clinical trials in San Diego, CA
48 studies for Non-Small Cell Lung Cancer are looking for participants at sites in and around San Diego (within about 30 miles). Open a study to see who can join and how to contact the study team.
Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →
A Study to Assess Adverse Events and Change in Disease Activity of Intravenous (IV) Telisotuzumab Adizutecan, Monotherapy or in Combination With Osimertinib, Compared to Standard of Care in Adult Participants With Locally Advanced or Metastatic EGFR-Mutated Non-Squamous Non-Small Cell Lung Cancer
RecruitingPhase 2/3
- UC San Diego Health - Moores Cancer Center /ID# 278836, La Jolla · 11 mi away
Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])
RecruitingPhase 3
- Kaiser Permanente-San Diego Zion, San Diego
- UC San Diego Moores Cancer Center, La Jolla · 11 mi away
A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
RecruitingPhase 1
- University of California, San Diego (UCSD) - Moores Cancer Center, La Jolla · 11 mi away
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
RecruitingPhase 1/2
- University of San Diego Moores Cancer Center, La Jolla · 11 mi away
Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After Standard Treatment for Early-Stage Non-Small Cell Lung Cancer, INSIGHT Trial
RecruitingPhase 3
- UC San Diego Moores Cancer Center, La Jolla · 11 mi away
Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors
RecruitingPhase 1
- University of California San Diego Moores Cancer Center, San Diego
A First in Human Study of ALX2004 With Advanced or Metastatic Selected Solid Tumors
RecruitingPhase 1
- ALX Center 9, La Jolla · 11 mi away
A Study of PHN-012 in Patients With Advanced Solid Tumors
RecruitingPhase 1
- PHN-012-001 Site, San Diego
A Study of Amivantamab in Participants With Advanced or Metastatic Solid Tumors Including Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer
RecruitingPhase 2
- University of California at San Diego, La Jolla · 11 mi away
A Study to Learn About the Study Medicine Called PF-08046054/SGN-PDL1V Versus Docetaxel in Adult Participants With Previously-Treated Programmed Cell Death Ligand 1 (PD-L1) Positive Non-Small-Cell Lung Cancer (NSCLC)
RecruitingPhase 3
- UC San Diego McGrath Outpatient Pavilion - Hillcrest, San Diego
- UC San Diego Medical Center - Hillcrest, San Diego
- UCSD Medical Center - Rancho Bernardo, San Diego
- and 3 more
Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing
RecruitingObservational study
- University of California San Diego, La Jolla · 11 mi away
A Study of JNJ-90301900 in Combination With Chemoradiation Followed by Consolidation Immunotherapy for Non-Small Cell Lung Cancer (NSCLC)
RecruitingPhase 2
- Moores Cancer Center at UC San Diego Health, La Jolla · 11 mi away
A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
RecruitingPhase 2
- University of California San Diego Health, La Jolla · 11 mi away
Symbiotic-Lung-20: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Different Anticancer Agents in Advanced Cancers
RecruitingPhase 1/2
- Scripps Clinic Torrey Pines (Scripps Cancer Center), La Jolla · 11 mi away
- Scripps Green Hospital, La Jolla · 11 mi away
- Scripps Shiley Pavilion, La Jolla · 11 mi away
Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer
RecruitingPhase 3
- Kaiser Permanente San Diego Mission Road, San Diego
Pan-tumor MRD Study
RecruitingObservational study
- Medical Oncology Associates of San Diego (MOASD), San Diego
- Medical Oncology Associates of San Diego, San Diego
Intratumoral N17350 in Advanced Solid Tumors
RecruitingPhase 1/2
- Scripps Clinic Torrey Pines - La Jolla, San Diego
Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and Other Investigational Agents for Lung Cancer
RecruitingPhase 2/3
- University Of California - San Diego Moores Cancer Center, La Jolla · 11 mi away
Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients With High PD-L1
RecruitingPhase 3
- Clinical Study Site, San Diego
ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation
RecruitingObservational study
- University of California, San Diego, La Jolla · 11 mi away
A Phase 1/1b Study of IAM1363 in HER2 Cancers
RecruitingPhase 1
- UCSD Moores Cancer Center, La Jolla · 11 mi away
A Study of Sofe-M in Participants With Selected Advanced Solid Tumors
RecruitingPhase 1
- University of California, San Diego (UCSD) - Moores Cancer Center, La Jolla · 11 mi away
Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous NSCLC Without Actionable Genomic Alterations
RecruitingPhase 3
- Research Site, San Diego
- Research Site, La Jolla · 11 mi away
Open-label Study of BBO-8520 in Adult Subjects With KRASG12C Non-small Cell Lung Cancer
RecruitingPhase 1
- University of California - San Diego Moores Cancer Center, La Jolla · 11 mi away
Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023]
RecruitingPhase 3
- Sharp Memorial Hospital ( Site 9544), San Diego
FT836 With or Without Chemotherapy and/or Monoclonal Antibodies, in Participants With Advanced Solid Tumors
RecruitingPhase 1
- UC San Diego Moores Cancer Center, La Jolla · 11 mi away
A Study to Evaluate KIN-2787 in Participants With BRAF and/or NRAS Mutation Positive Solid Tumors
RecruitingPhase 1
- University of California San Diego, Moores Cancer Center, San Diego
Phase III, Open-label Study of First-line Osimertinib With or Without Datopotamab Deruxtecan for EGFRm Locally Advanced or Metastatic Non-small Cell Lung Cancer
RecruitingPhase 3
- Research Site, San Diego
Study to Assess the Efficacy and Safety of Rina-S in Participants With Non-small Cell Lung Cancer
RecruitingPhase 2
- Kaiser Permanente San Diego Mission Road, San Diego
Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial
RecruitingPhase 3
- UC San Diego Medical Center - Hillcrest, San Diego
- California Protons Cancer Therapy Center, San Diego
- UC San Diego Moores Cancer Center, La Jolla · 11 mi away
A Study of BH-30643 in Subjects With Locally Advanced or Metastatic NSCLC Harboring EGFR and/or HER2 Mutations
RecruitingPhase 1/2
- UC San Diego Moores Cancer Center, La Jolla · 11 mi away
Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)
RecruitingPhase 1/2
- University of California, San Diego; Moores Cancer Center, San Diego
Study of RAS(ON) Inhibitors in Patients With Advanced RAS-mutated NSCLC
RecruitingPhase 1/2
- University of California, San Diego Moores Cancer Center, San Diego
A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression
RecruitingPhase 1/2
- UCSD Moores Cancer Center, La Jolla · 11 mi away
Comparing Combinations of Targeted Drugs for Advanced Non-Small Cell Lung Cancer That Has EGFR and MET Gene Changes (A Lung-MAP Treatment Trial)
RecruitingPhase 2
- UC San Diego Moores Cancer Center, La Jolla · 11 mi away
BBO-11818 in Adult Subjects With KRAS Mutant Cancer
RecruitingPhase 1
- University of California San Diego Moores Cancer Center, San Diego
A Study to Investigate the Efficacy and Safety of Dato-DXd With or Without Osimertinib Compared With Platinum Based Doublet Chemotherapy in Participants With EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer
RecruitingPhase 3
- Research Site, San Diego
- Research Site, La Jolla · 11 mi away
Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has Increased Copies of the MET Gene (An Expanded Lung-MAP Treatment Trial)
RecruitingPhase 2
- UC San Diego Moores Cancer Center, La Jolla · 11 mi away
Adding the Immunotherapy Drug Cemiplimab to Usual Treatment for People With Advanced Non-Small Cell Lung Cancer Who Had Previous Treatment With Platinum Chemotherapy and Immunotherapy (An Expanded Lung-MAP Treatment Trial)
RecruitingPhase 2/3
- Kaiser Permanente-San Diego Zion, San Diego
- UC San Diego Moores Cancer Center, La Jolla · 11 mi away
Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)
RecruitingPhase 2
- UC San Diego Moores Cancer Center, La Jolla · 11 mi away
A Study to Evaluate the Efficacy and Safety of Sutetinib Maleate Capsule in Locally Advanced or Metastatic NSCLC
RecruitingPhase 2
- University of California San Diego Moores Cancer Center, La Jolla · 11 mi away
A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors
RecruitingPhase 1/2
- University of California San Diego (UC San Diego) Health - Jacobs Medical Center - Moores Cancer Center, La Jolla · 11 mi away
A Phase 1/2 Clinical Trial to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of HMBD-501 in Patients With HER3-Expressing Solid Tumors
RecruitingPhase 1/2
- Research Site, La Jolla · 11 mi away
EZH2 Inhibitor, Tulmimetostat, and PD-1 Blockade for Treatment of Advanced Non-small Cell Lung Cancer
RecruitingPhase 1/2
- VA San Diego Healthcare System, San Diego, CA, San Diego
Retifanlimab and Ruxolitinib In Solid Malignancies
RecruitingPhase 1/2
- University of California, San Diego Moores Cancer Center, La Jolla · 11 mi away
SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
RecruitingObservational study
- Massive Bio SYNERGY-AI site, La Jolla · 11 mi away
A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression
RecruitingPhase 1/2
- UCSD Moores Cancer Center, La Jolla · 11 mi away
Study of CRX100 as Monotherapy and in Combination With Pembrolizumab in Patients With Advanced Solid Malignancies
RecruitingPhase 1
- UC San Diego Moores Cancer Center, La Jolla · 11 mi away
Non-Small Cell Lung Cancer trials in other cities
- Houston, TX145 studies
- New York City, NY121 studies
- Arlington, VA104 studies
- Nashville, TN97 studies
- Boston, MA90 studies
- Los Angeles, CA87 studies
- St. Louis, MO73 studies
- Chicago, IL61 studies
- Baltimore, MD60 studies
- San Antonio, TX59 studies
- Columbus, OH57 studies
- Washington, DC55 studies
Other studies in San Diego
- Breast Cancer41 studies
- Cancer (all types)32 studies
- Prostate Cancer31 studies
- Metastatic Cancer30 studies
- Colorectal Cancer25 studies
- Ovarian Cancer24 studies
- Pancreatic Cancer24 studies
- Lung Cancer23 studies
- Obesity23 studies
- Heart Failure23 studies
- Depression21 studies
- Melanoma18 studies
From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.