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ALS and Motor Neuron Disease clinical trials recruiting in the U.S.

23 studies for ALS and Motor Neuron Disease are recruiting participants at sites across the United States.

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Recently updated studies

Acamprosate in C9orf72 Hexanucleotide Repeat Expansion Amyotrophic Lateral Sclerosis (ACALS)

RecruitingPhase 1
Ages 18 to 99 · All sexes · Updated Oct 1, 2026 · NCT07204977

Developing New Ways to Detect Respiratory Impairment Early in ALS

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07844590

Study of Inherited Neurological Disorders

RecruitingObservational study
Ages 2 to 120 · All sexes · Updated Sep 28, 2026 · NCT00004568

Electrical Impedance Myography: Natural History Studies inNeuromuscular Disorders and Healthy Volunteers

RecruitingHealthy volunteers welcome
Ages 2 to 110 · All sexes · Updated Sep 28, 2026 · NCT01900132

Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

RecruitingObservational study
Ages 18 to 110 · All sexes · Updated Sep 17, 2026 · NCT03225144

Biofluid Research on Age-Related or Inherited Neurodegeneration

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 1, 2026 · NCT07798700

Clinical, Molecular and Imaging Biomarkers in Spinal and Bulbar Muscular Atrophy (SBMA)

RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 120 · Men · Updated Aug 13, 2026 · NCT04944940

Healing ALS Registry Observational Study (HAROS)

RecruitingObservational study
Ages 18 to 110 · All sexes · Updated Jun 24, 2026 · NCT07233148

Clinical Procedures to Support Research in ALS

RecruitingObservational study
Ages 18 and older · All sexes · Updated Jun 15, 2026 · NCT03489278

A Study of Ranolazine in ALS

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jun 8, 2026 · NCT06527222

INdependence Through Endovascular Neuroprosthetic Technology (INTENT): an Early Feasibility Study

Recruiting
Ages 22 and older · All sexes · Updated May 11, 2026 · NCT07543367

Non-invasive BCI-controlled Assistive Devices

RecruitingHealthy volunteers welcome
Ages 18 to 80 · All sexes · Updated May 1, 2026 · NCT05183152

The National Amyotrophic Lateral Sclerosis Registry

RecruitingObservational study
Ages 18 and older · All sexes · Updated Apr 29, 2026 · NCT01772602

AMX0114 in Adult Participants With Amyotrophic Lateral Sclerosis

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Apr 14, 2026 · NCT06665165

Impact of Physical Functioning on Patient-Reported Outcomes in ALS Patients at TidalHealth

RecruitingObservational study
Ages 18 and older · All sexes · Updated Mar 24, 2026 · NCT07491484

Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq)

RecruitingObservational study
1 Month – 30 Years · All sexes · Updated Mar 18, 2026 · NCT05354622

Spastic Paraplegia - Centers of Excellence Research Network

RecruitingObservational study
All ages · All sexes · Updated Mar 18, 2026 · NCT06553976

Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease

Recruiting
Ages 18 and older · All sexes · Updated Mar 17, 2026 · NCT07478172

Imaging Biomarkers in ALS

RecruitingObservational studyHealthy volunteers welcome
Ages 21 to 75 · All sexes · Updated Dec 2, 2025 · NCT02567136

Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At Home Measures

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Nov 21, 2025 · NCT05137665

Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patients

RecruitingPhase 3
Ages 18 to 81 · All sexes · Updated Sep 12, 2025 · NCT03127267

ALS Research Collaborative

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Mar 20, 2025 · NCT06885918

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.