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Lung Cancer clinical trials in Dallas, TX

27 studies for Lung Cancer are looking for participants at sites in and around Dallas (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

RecruitingPhase 3
  • Parkland Memorial Hospital, Dallas
  • UT Southwestern Simmons Cancer Center - RedBird, Dallas
  • UT Southwestern/Simmons Cancer Center-Dallas, Dallas
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT04267848

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2
  • UT Southwest Simmons Cancer Center, Dallas
Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750

Substudy 01I: A Study of Investigational Agents in Participants With Previously Treated Stage IV Squamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-01I/KEYMAKER-U01I)

RecruitingPhase 2
  • Texas Oncology - DFW ( Site 8003), Dallas
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06780098

Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial

RecruitingPhase 3
  • Parkland Memorial Hospital, Dallas
  • UT Southwestern/Simmons Cancer Center-Dallas, Dallas
Ages 70 and older · All sexes · Updated Oct 1, 2026 · NCT06096844

Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With EGFR-Mutant Lung Cancer

RecruitingPhase 3
  • UT Southwestern/Simmons Cancer Center-Dallas, Dallas
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT04181060

Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors

RecruitingPhase 1
  • SCRI at Mary Crowley, Dallas
  • University of Texas Southwestern Medical Center, Dallas
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06625775

Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)

RecruitingPhase 3
  • Texas Oncology Dallas, Dallas
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT06881784

Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

RecruitingPhase 3
  • Texas Oncology - DFW, Dallas
  • Texas Oncology - DFW, Dallas
  • Texas Oncology - DFW, Dallas
  • and 2 more
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07222566

A Registry for People With Lung Cancer

RecruitingObservational study
  • Baylor University Medical Center (Data Collection Only), Dallas
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06424327

Study of RMC-5127 in Patients With Advanced KRAS G12V-Mutant Solid Tumors

RecruitingPhase 1
  • NEXT - Dallas, Dallas
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07349537

AVENTINE-1: Study of AVZO-1418 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Solid Tumors (AVZO-1418-1001)

RecruitingPhase 1/2
  • Avenzo Therapeutics Recruiting Site, Dallas
Ages 18 to 75 · All sexes · Updated Sep 4, 2026 · NCT07038343

Feasibility Study of Personalized Ultra-fractionated Stereotactic Ablative Radiotherapy (PULSAR) for Cancers of the Central Lung

RecruitingEarly phase 1
  • University of Texas Southwestern Medical Center, Dallas
Ages 18 and older · All sexes · Updated Jun 29, 2026 · NCT06712745

Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors

RecruitingPhase 1
  • Sarah Cannon Research Institute at Mary Crowley, Dallas
Ages 18 and older · All sexes · Updated Jun 3, 2026 · NCT06040541

A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements

RecruitingPhase 1/2
  • UT Southwestern Medical Center, Dallas
Ages 12 and older · All sexes · Updated May 27, 2026 · NCT03093116

Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS

RecruitingPhase 1/2
  • Mary Crowley Cancer Research, Dallas
Ages 18 and older · All sexes · Updated May 15, 2026 · NCT05379985

A Study of LP-300 With Carboplatin and Pemetrexed in Never Smokers With Advanced Lung Adenocarcinoma

RecruitingPhase 2
  • UT Southwestern Medical Center, Dallas
Ages 18 and older · All sexes · Updated May 4, 2026 · NCT05456256

Metabolic Biomarkers in Thoracic Cancers

Recruiting
  • University of Texas Southwestern Medical Center, Dallas
Ages 18 and older · All sexes · Updated May 1, 2026 · NCT02095808

Multiparametric Image Analysis and Correlation With Outcomes in Lung Cancer Screening and Early Stage Lung Cancer

RecruitingObservational study
  • UT Southwestern Medical Center, Dallas
Ages 18 to 99 · All sexes · Updated Apr 22, 2026 · NCT03563976

Efficacy and Safety of a Single Dose of LS301-IT for Fluorescence Intraoperative Molecular Imaging (IMI) for Patients Undergoing Lung Cancer Resection for Non Small Cell Lung Cancer

RecruitingPhase 2
  • University of Texas Southwestern Medical Center, Dallas
Ages 18 and older · All sexes · Updated Apr 20, 2026 · NCT07276789

A Phase 1 Study of CPO301 in Adult Patients With Advanced or Metastatic Solid Tumors

RecruitingPhase 1
  • NEXT Dallas, Dallas
Ages 18 and older · All sexes · Updated Mar 20, 2026 · NCT05948865

A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

RecruitingPhase 1
  • Mary Crowley Cancer Research, Dallas
  • Baylor University Medical Center, Dallas
Ages 18 and older · All sexes · Updated Feb 13, 2026 · NCT06778863

Phase 1/2a Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of WEF-001 as Monotherapy in Advanced KRAS-Mutant Solid Tumours.

RecruitingPhase 1/2
  • NEXT Oncology Dallas, Dallas
Ages 18 and older · All sexes · Updated Jan 29, 2026 · NCT07148128

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Dallas
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

A Study to Evaluate TROP2 ADC LCB84 Single Agent and in Combination With an Anti-PD-1 Ab in Advanced Solid Tumors

RecruitingPhase 1/2
  • Mary Crowley Cancer Research, Dallas
  • University of Texas Southwestern Medical Center, Dallas
Ages 18 and older · All sexes · Updated Sep 24, 2025 · NCT05941507

About Lung Cancer

Lung cancer forms in tissues of the lung, usually in the cells that line the air passages. It is the leading cause of cancer death in both men and women.

More about Lung Cancer on MedlinePlus

Lung Cancer trials in other cities

Other studies in Dallas

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.