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Glioma clinical trials in Philadelphia, PA

16 studies for Glioma are looking for participants at sites in and around Philadelphia (within about 30 miles). Open a study to see who can join and how to contact the study team.

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A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)

RecruitingPhase 1/2
  • Children's Hospital of Philadelphia, Philadelphia
  • Saint Christopher's Hospital for Children, Philadelphia
  • Alfred I duPont Hospital for Children, Wilmington · 25 mi away
12 Months – 21 Years · All sexes · Updated Oct 1, 2026 · NCT05099003

Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII

RecruitingPhase 2
  • Thomas Jefferson University, Sidney Kimmel Comprehensive Cancer Center, Philadelphia
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07326566

A Study of Repotrectinib in Pediatric and Young Adult Subjects Harboring ALK, ROS1, OR NTRK1-3 Alterations

RecruitingPhase 1/2
  • Children's Hospital of Philadelphia-Center for Childhood Cancer Research, Philadelphia
Up to age 25 · All sexes · Updated Sep 25, 2026 · NCT04094610

Evaluation of 18F-Fluciclovine Positron Emission Tomography - Magnetic Resonance Imaging (PET-MRI) in LGG

RecruitingEarly phase 1
  • The Children s Hospital of Philadelphia, Philadelphia
Ages 1 to 21 · All sexes · Updated Sep 22, 2026 · NCT05555550

Targeted Pediatric High-Grade Glioma Therapy

RecruitingObservational study
  • Children's Hospital of Philadelphia, Philadelphia
12 Months – 39 Years · All sexes · Updated Sep 8, 2026 · NCT05839379

Study of Olutasidenib and Temozolomide in HGG

RecruitingPhase 2
  • Children's Hospital of Philadelphia, Philadelphia
Ages 12 to 39 · All sexes · Updated Sep 1, 2026 · NCT06161974

SIGMA (Safusidenib in IDH1 Mutant Glioma Maintenance)

RecruitingPhase 3
  • Thomas Jefferson University Hospital, Philadelphia
Ages 18 and older · All sexes · Updated Aug 28, 2026 · NCT05303519

PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma

RecruitingPhase 2
  • Children's Hospital of Philadelphia, Philadelphia
Ages 3 to 39 · All sexes · Updated Aug 24, 2026 · NCT05096481

Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021)

RecruitingPhase 1
  • Children's Hospital of Philadelphia, Philadelphia
Ages 1 to 25 · All sexes · Updated Aug 18, 2026 · NCT04485559

A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations

RecruitingPhase 2
  • Thomas Jefferson University, Philadelphia
Ages 8 and older · All sexes · Updated Jul 27, 2026 · NCT05503797

Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors

RecruitingPhase 1/2
  • Children's Hospital of Philadelphia, Philadelphia
Ages 4 to 39 · All sexes · Updated Jul 20, 2026 · NCT05278208

Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

RecruitingEarly phase 1Healthy volunteers welcome
  • Children's Hospital of Philadelphia, Philadelphia
Ages 1 to 21 · All sexes · Updated Jun 29, 2026 · NCT06333899

Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

RecruitingPhase 2
  • Children's Hospital of Philadelphia, Philadelphia
12 Months – 39 Years · All sexes · Updated May 29, 2026 · NCT05843253

A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion

RecruitingEarly phase 1
  • Children's Hospital of Philadelphia, Philadelphia
Up to age 21 · All sexes · Updated Mar 18, 2026 · NCT04655404

All-Trans Retinoic Acid (ATRA) Plus PD-1 Inhibition in Recurrent IDH-Mutant Glioma

RecruitingPhase 2
  • University of Pennsylvania, Philadelphia
Ages 18 and older · All sexes · Updated Feb 20, 2026 · NCT05345002

18F-Fluciclovine PET-MRI in High-grade Glioma

RecruitingEarly phase 1
  • Children's Hospital of Philadelphia, Philadelphia
Ages 1 to 21 · All sexes · Updated Dec 4, 2025 · NCT05553041

Glioma trials in other cities

Other studies in Philadelphia

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.