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Bladder Cancer clinical trials in Durham, NC

20 studies for Bladder Cancer are looking for participants at sites in and around Durham (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • Durham VA Medical Center, Durham
Ages 40 to 75 · All sexes · Updated Oct 2, 2026 · NCT05334069

Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to Radiation Therapy Compared to the Usual Chemotherapy Treatment During Radiation Therapy for Bladder Cancer, PARRC Trial

RecruitingPhase 2
  • UNC Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06770582

Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

RecruitingPhase 2
  • UNC Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT03866382

Symbiotic-GU-06: A Study to Learn About PF-08634404 Alone or In Combination With Enfortumab Vedotin in Urothelial Cancer

RecruitingPhase 1/2
  • Duke University Medical Center (location of scans), Durham
  • Duke University Medical Center - Duke University Hospital (location of scans), Durham
  • Duke University Medical Center, Durham
  • and 1 more
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07421700

A Study to Learn About the Study Medicine PF-08052667 in People With Bladder Cancer

RecruitingPhase 1
  • Biorepository and Precision Pathology Center (BRPC), Durham
  • Duke Cancer Institute, Durham
  • Substrate Services Core Research Support (SSCRS), Durham
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07206225

DESTINY-PANTUMOUR04

RecruitingObservational study
  • Research Site, Durham
Ages 18 to 130 · All sexes · Updated Sep 25, 2026 · NCT07124000

A Study Evaluating the Safety, Efficacy, and Pharmacokinetics (PK) of EVOLVE104 in Participants With Advanced Urothelial and Squamous Cell Carcinomas

RecruitingPhase 1
  • Duke University Medical Center - Duke Cancer Center, Durham
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT07217171

ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation

RecruitingObservational study
  • UNC- Chapel Hill, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT05059444

Phase 2 Study to Evaluate Safety and Efficacy of Cretostimogene Grenadenorepvec in High-Risk NMIBC

RecruitingPhase 2
  • University of North Carolina, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT06567743

The Vanguard Study: Testing a New Way to Screen for Cancer

RecruitingHealthy volunteers welcome
  • Durham VA Medical Center, Durham
  • UNC Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
Ages 45 to 75 · All sexes · Updated Sep 2, 2026 · NCT06995898

FORAGER-1: A Study of Vepugratinib (LY3866288; LOXO-435) in Participants With Cancer With a Change in a Gene Called FGFR3

RecruitingPhase 1
  • University of North Carolina (UNC) - Chapel Hill, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Aug 20, 2026 · NCT05614739

Study of Datopotamab Deruxtecan Plus Carboplatin or Cisplatin Versus Gemcitabine Plus Carboplatin or Cisplatin in Participants With Locally Advanced or Metastatic Urothelial Carcinoma

RecruitingPhase 2/3
  • Research Site, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Aug 20, 2026 · NCT07129993

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients Receiving the Usual Chemotherapy Treatment for Bladder Cancer, ARCHER Study

RecruitingPhase 3
  • Duke University Medical Center, Durham
  • UNC Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT07097142

LEGEND Study: EG-70 in NMIBC Patients BCG-Unresponsive and High-Risk NMIBC Incompletely Treated With BCG or BCG-Naïve

RecruitingPhase 1/2
  • Duke Health - Duke Cancer Center, Durham
  • UNC Chapel Hill Hospital, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Aug 7, 2026 · NCT04752722

Comparison of Intravesical Therapy and Surgery as Treatment Options for Bladder Cancer 2

RecruitingObservational study
  • University of North Carolina, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Jul 31, 2026 · NCT07225127

A Study of Disitamab Vedotin Alone or With Pembrolizumab in Urothelial Cancer That Expresses HER2

RecruitingPhase 2
  • UNC Hospitals, The University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
  • UNC Lineberger Comprehensive Cancer Center / University of North Carolina, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Jul 22, 2026 · NCT04879329

PROGRESS: Precision Oncology Using Genomic Reflexive Evaluations for Study Selection and Survival

Recruiting
  • Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Jul 14, 2026 · NCT06896162

Characterizing the Microvascular Environment of Bladder Cancer With Super-Resolution Ultrasound Localization Microscopy

RecruitingObservational study
  • Duke University, Durham
Ages 18 and older · All sexes · Updated May 4, 2026 · NCT06986304

A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

RecruitingPhase 1
  • Duke Cancer Institute, Durham
Ages 18 and older · All sexes · Updated Feb 13, 2026 · NCT06778863

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Chapel Hill · 10 mi away
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

About Bladder Cancer

Bladder cancer symptoms range from lower back pain to blood in your urine. Read about important risk factors and find a list of treatments available

More about Bladder Cancer on MedlinePlus

Bladder Cancer trials in other cities

Other studies in Durham

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.