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Head and Neck Cancer clinical trials in Pittsburgh, PA

11 studies for Head and Neck Cancer are looking for participants at sites in and around Pittsburgh (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2
  • University of Pittsburgh Medical Center, Pittsburgh
Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750

FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC

RecruitingPhase 2/3
  • Site #0103, Pittsburgh
  • Site #0123, Pittsburgh
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06788990

Distance-Based Exercise to Preserve Function and Prevent Disability

Recruiting
  • UPMC Hillman Cancer Center, Pittsburgh
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT07059884

A Study of [225Ac]Ac-AKY-1189 in Patients With Solid Tumors

RecruitingPhase 1
  • UPMC, Pittsburgh
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07020117

Bevonescein for Improved Intraoperative Nerve Visualization to Improve Voice Outcomes in Thyroidectomy Patients

RecruitingPhase 2
  • UMPC Hillman Cancer Center, Pittsburgh
Ages 18 and older · All sexes · Updated Aug 31, 2026 · NCT07631650

Transoral Surgical Resection Followed by De-escalated Adjuvant IMRT in Resectable p16+ Locally Advanced Oropharynx Cancer

RecruitingPhase 2
  • UPMC Hillman Cancer Center, Pittsburgh
Ages 18 and older · All sexes · Updated Jul 21, 2026 · NCT05388773

Lead-212 PSV359 Therapy for Patients With Solid Tumors

RecruitingPhase 1/2
  • University of Pittsburgh Medical Center, Pittsburgh
Ages 18 to 90 · All sexes · Updated Jul 6, 2026 · NCT06710756

A Study of Dostarlimab vs Placebo After Chemoradiation in Adult Participants With Locally Advanced Unresected Head and Neck Squamous Cell Carcinoma

RecruitingPhase 3
  • GSK Investigational Site, Pittsburgh
Ages 18 and older · All sexes · Updated May 26, 2026 · NCT06256588

The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study

RecruitingObservational study
  • Allegheny Health Network, Pittsburgh
Ages 18 and older · All sexes · Updated Mar 5, 2026 · NCT04075305

Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors

RecruitingPhase 1
  • UPMC Hillman Cancer Center, Pittsburgh
Ages 18 and older · All sexes · Updated Aug 15, 2025 · NCT04429542

Prospective Data Registry and Quality of Life Assessment of Patients Undergoing Radiotherapy With the RefleXion Medical Radiotherapy System

RecruitingObservational study
  • University of Pittsburgh Medical Center, Pittsburgh
All ages · All sexes · Updated Aug 15, 2025 · NCT05406167

About Head and Neck Cancer

Head and neck cancer includes cancers of the mouth, nose, sinuses, salivary glands, throat, and lymph nodes. Read the different symptoms of each type.

More about Head and Neck Cancer on MedlinePlus

Head and Neck Cancer trials in other cities

Other studies in Pittsburgh

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.