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Prostate Cancer clinical trials in Pittsburgh, PA

23 studies for Prostate Cancer are looking for participants at sites in and around Pittsburgh (within about 30 miles). Open a study to see who can join and how to contact the study team.

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Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging

RecruitingPhase 3
  • UPMC-Magee Womens Hospital, Pittsburgh
  • UPMC-Saint Margaret, Pittsburgh
  • UPMC Hillman Cancer Center, Pittsburgh
  • and 9 more
Ages 18 and older · Men · Updated Nov 13, 2026 · NCT04423211

Study of AMG 509 in Participants With Metastatic Castration-Resistant Prostate Cancer

RecruitingPhase 1
  • University of Pittsburgh Medical Center, Pittsburgh
Ages 18 and older · Men · Updated Nov 12, 2026 · NCT04221542

Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

RecruitingPhase 2
  • UPMC Hillman Cancer Center, Pittsburgh
  • UPMC-Passavant Hospital, Pittsburgh
  • UPMC-Saint Clair Hospital Cancer Center, Pittsburgh
  • and 2 more
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT03866382

Circulating Tumor DNA in High Risk Localized Prostate Cancer

RecruitingObservational study
  • UPMC Hillman Cancer Center, Pittsburgh
Ages 18 and older · Men · Updated Nov 9, 2026 · NCT07222436

A Study of LY4257496 in Participants With Cancer (OMNIRAY)

RecruitingPhase 1
  • University of Pittsburgh Medical Center, Pittsburgh
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07114601

Distance-Based Exercise to Preserve Function and Prevent Disability

Recruiting
  • UPMC-Magee Womens Hospital, Pittsburgh
  • UPMC Hillman Cancer Center, Pittsburgh
  • UPMC-Passavant Hospital, Pittsburgh
  • and 2 more
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07059884

Testing the Addition of Docetaxel (Chemotherapy) to the Usual Treatment (Hormonal Therapy and Apalutamide) for Metastatic Prostate Cancer, ASPIRE Trial

RecruitingPhase 3
  • Allegheny General Hospital, Pittsburgh
  • West Penn Hospital, Pittsburgh
  • Jefferson Hospital, Jefferson Hills · 11 mi away
  • and 3 more
Ages 18 and older · Men · Updated Nov 3, 2026 · NCT06931340

A Study of [225Ac]Ac-AKY-2519 in Patients With Metastatic Castration-Resistant Prostate Cancer

RecruitingPhase 1
  • UPMC, Pittsburgh
Ages 18 and older · Men · Updated Nov 2, 2026 · NCT07581184

Study of JANX007 in Subjects With Metastatic Castration-Resistant Prostate Cancer (ENGAGER-PSMA-01)

RecruitingPhase 1
  • UPMC Hillman Cancer Center, Pittsburgh
Ages 18 to 100 · Men · Updated Oct 29, 2026 · NCT05519449

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

RecruitingPhase 3
  • UPMC-Magee Womens Hospital, Pittsburgh
  • UPMC-Saint Margaret, Pittsburgh
  • UPMC Hillman Cancer Center, Pittsburgh
  • and 6 more
Ages 18 and older · Men · Updated Oct 23, 2026 · NCT05946213

A Study of Xaluritamig Plus Abiraterone Versus Investigator's Choice in Participants With Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer

RecruitingPhase 3
  • University of Pittsburgh Medical Center, Pittsburgh
Ages 18 and older · Men · Updated Oct 20, 2026 · NCT07213674

AZD2265 Compared With Standard of Care in PSMA-positive Metastatic Castration-resistant Prostate Cancer (VECTRA-01)

RecruitingPhase 3
  • Research Site, Pittsburgh
Ages 18 and older · Men · Updated Oct 19, 2026 · NCT07611110

A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA Mutation

RecruitingPhase 3
  • Research Site, Pittsburgh
Ages 18 and older · Men · Updated Oct 14, 2026 · NCT06952803

Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer

RecruitingPhase 3
  • University of Pittsburgh Cancer Institute (UPCI), Pittsburgh
  • UPMC-Shadyside Hospital, Pittsburgh
Ages 18 and older · Men · Updated Oct 8, 2026 · NCT03678025

FOG-001 in Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2
  • University of Pittsburgh Medical Center, Hillman Cancer Center, Pittsburgh
Ages 18 and older · All sexes · Updated Oct 7, 2026 · NCT05919264

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2
  • University of Pittsburgh Medical Center, Pittsburgh
Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750

Trial of Xaluritamig in Adults With Metastatic Castration-resistant Prostate Cancer

RecruitingPhase 1
  • University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh
Ages 18 and older · Men · Updated Sep 15, 2026 · NCT07493512

Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors

RecruitingPhase 1
  • University of Pittsburg Medical Center (UPCM), Pittsburgh
Ages 18 and older · All sexes · Updated Jun 11, 2026 · NCT05283330

Study of CX-5461 in Patients With Solid Tumours and BRCA1/2, PALB2 or Homologous Recombination Deficiency (HRD) Mutation

RecruitingPhase 1
  • UPMC Hillman Cancer Center, Pittsburgh
Ages 18 and older · All sexes · Updated Jun 8, 2026 · NCT04890613

Long-Term Safety of Lutetium (177Lu) Vipivotide Tetraxetan in Participants With Prostate Cancer

RecruitingPhase 4
  • Univ of Pittsburgh Medical Center, Pittsburgh
Ages 18 to 100 · Men · Updated Jun 4, 2026 · NCT05803941

TERPS Trial for de Novo Oligometastic Prostate Cancer

RecruitingPhase 2
  • UPMC Hillman Cancer Center, Pittsburgh
Ages 18 and older · Men · Updated Jun 3, 2026 · NCT05223803

Androgen Suppression Combined With Nodal Irradiation and Dose Escalated Prostate Treatment

RecruitingPhase 3
  • Allegheny General Hospital, Pittsburgh
  • West Penn Hospital, Pittsburgh
  • Jefferson Hospital, Jefferson Hills · 11 mi away
  • and 2 more
Ages 18 and older · Men · Updated Apr 14, 2026 · NCT06235697

The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study

RecruitingObservational study
  • Allegheny Health Network, Pittsburgh
Ages 18 and older · All sexes · Updated Mar 5, 2026 · NCT04075305

About Prostate Cancer

Prostate cancer is one of the most common types of cancer among American men. The risk goes up as men age. Learn about symptoms, tests, and treatment.

More about Prostate Cancer on MedlinePlus

Prostate Cancer trials in other cities

Other studies in Pittsburgh

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.