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Pain clinical trials in Durham, NC

15 studies for Pain are looking for participants at sites in and around Durham (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Pivotal Study on the NOVABLOC System for Patients Undergoing Primary Total Knee Arthroplasty

Recruiting
  • University of North Carolina, Chapel Hill · 10 mi away
Ages 21 and older · All sexes · Updated Aug 21, 2026 · NCT07191067

Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

RecruitingObservational studyHealthy volunteers welcome
  • Duke University Health System, Durham
Ages 0 to 20 · All sexes · Updated Aug 21, 2026 · NCT04278404

Behavioral Pain Intervention for Older Cancer Patients

Recruiting
  • Duke Cancer Network, Durham
Ages 55 and older · Women · Updated Aug 12, 2026 · NCT07300995

Pain With Dementia

RecruitingHealthy volunteers welcome
  • Duke University Medical Center, Durham
Ages 50 and older · All sexes · Updated Aug 5, 2026 · NCT06854718

Anesthetics and Analgesics in Children

RecruitingObservational study
  • Duke University Medical Center, Durham
Ages 0 to 17 · All sexes · Updated Aug 5, 2026 · NCT03427736

Adaptive Coping Skills Training to Improve Psychological Distress Among Cardiorespiratory Failure Survivors

Recruiting
  • Duke University Medical Center, Durham
Ages 18 and older · All sexes · Updated Jul 23, 2026 · NCT06538246

A New Intervention to Improve Function in Veterans With Anxiety and Depression

RecruitingPhase 2
  • Durham VA Medical Center, Durham, NC, Durham
Ages 18 to 65 · All sexes · Updated Jul 7, 2026 · NCT06188923

Neuroimaging of Opioid Phase (OPAL)

RecruitingHealthy volunteers welcome
  • Duke University Medical Center, Durham
Ages 18 and older · Women · Updated Jun 3, 2026 · NCT05905419

Collecting Outcomes and Managing Pain After Surgery

Recruiting
  • Duke Orthopaedics, Durham
Ages 18 to 90 · All sexes · Updated May 5, 2026 · NCT03834818

Local Radiofrequency Ablation Plus External Beam Radiation for the Treatment of Painful Thoracic and Lumbar Spine Tumors

RecruitingObservational study
  • UNC Hospitals, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Apr 23, 2026 · NCT07479199

Optimizing Perioperative Analgesia to Lower Pain Following Cleft Palate Surgery

RecruitingPhase 4
  • Duke University Medical Center, Durham
6 Months – 4 Years · All sexes · Updated Apr 14, 2026 · NCT06962306

Sensory Spinal Cord Stimulation

Recruiting
  • Ambulatory Care Center, Chapel Hill · 10 mi away
Ages 18 to 85 · All sexes · Updated Feb 4, 2026 · NCT07095036

Peer Support for Adolescents and Emerging Adults With Sickle Cell Pain

Recruiting
  • Wake Forest Baptist Hospital, Durham
Ages 16 to 30 · All sexes · Updated Jan 7, 2026 · NCT06374238

Cognitive Behavioral Theory-assisted Virtual Reality for Chronic CANcer Pain (VR-CAN)

Recruiting
  • Duke University School of Medicine, Durham
Ages 18 and older · All sexes · Updated Jan 6, 2026 · NCT07318519

Mobile Neurofeedback for Low Back Pain

RecruitingHealthy volunteers welcome
  • Duke University Medical Center, Department of Psychiatry, Durham
Ages 18 to 90 · All sexes · Updated Dec 17, 2025 · NCT05669027

About Pain

Pain is a feeling triggered in the nervous system. You may feel it as a prick, tingle, sting, burn, or ache. Read about the causes and what can help.

More about Pain on MedlinePlus

Pain trials in other cities

Other studies in Durham

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.