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Post-COVID Conditions (Long COVID) clinical trials in Chicago, IL

11 studies for Post-COVID Conditions (Long COVID) are looking for participants at sites in and around Chicago (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

A Clinical Study of Molnupiravir to Prevent Severe Illness From Coronavirus Disease 2019 (COVID-19) in People Who Are High Risk (MK-4482-023)

RecruitingPhase 3
  • Rush University Medical Center ( Site 3748), Chicago
Ages 18 and older · All sexes · Updated Oct 5, 2026 · NCT06667700

A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely Immunocompromised

RecruitingPhase 3
  • Northwestern Memorial Hospital, Chicago
  • Northwestern University Feinberg School of Medicine, Chicago
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07013474

Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID

RecruitingPhase 3
  • Illinois Research Network (ILLInet), University of Illinois Chicago, Chicago
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06631287

Dime La VerDAD: Verify, Debunk, and Disseminate

RecruitingHealthy volunteers welcome
  • University of Chicago, Chicago
Ages 18 to 99 · All sexes · Updated Aug 26, 2026 · NCT06417762

Phase III DAS181 Lower Tract PIV Infection in Immunocompromised Subjects (Substudy: DAS181 for COVID-19): RCT Study

RecruitingPhase 3
  • Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago
All ages · All sexes · Updated Jun 23, 2026 · NCT03808922

Cognitive-Sensorimotor Function in Long-COVID

RecruitingObservational studyHealthy volunteers welcome
  • Jesse Brown VA Medical Center, Chicago, IL, Chicago
Ages 18 and older · All sexes · Updated May 8, 2026 · NCT06850350

Dysbiosis & Long COVID

RecruitingObservational studyHealthy volunteers welcome
  • The University of Chicago, Chicago
Ages 18 to 80 · All sexes · Updated Mar 2, 2026 · NCT06825819

A Pilot Clinical Evaluation of Astepro® Nasal Spray for Management of Early SARS-CoV-2 Infection

RecruitingPhase 4Healthy volunteers welcome
  • University of Chicago, Chicago
Ages 18 and older · All sexes · Updated Nov 10, 2025 · NCT06008860

Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia

RecruitingPhase 3
  • University of Illinois Health, Chicago
Ages 18 and older · All sexes · Updated Jul 12, 2024 · NCT02735707

Convalescent Plasma as a Possible Treatment for COVID-19

RecruitingPhase 2
  • University of Illinois at Chicago, Chicago
Ages 40 and older · All sexes · Updated Jun 22, 2020 · NCT04442191

About Post-COVID Conditions (Long COVID)

Anyone who had COVID-19 can have ongoing symptoms. Learn about post-COVID conditions (long COVID), including symptoms, diagnosis, treatments, and prevention.

More about Post-COVID Conditions (Long COVID) on MedlinePlus

Post-COVID Conditions (Long COVID) trials in other cities

Other studies in Chicago

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.