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Breast Cancer clinical trials in Durham, NC
63 studies for Breast Cancer are looking for participants at sites in and around Durham (within about 30 miles). Open a study to see who can join and how to contact the study team.
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The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
RecruitingPhase 1/2
- Duke University, Durham
Phase IIIb Study of Ribociclib + ET in Early Breast Cancer
RecruitingPhase 3
- Duke Cancer Network, Durham
Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
RecruitingObservational studyHealthy volunteers welcome
- Durham VA Medical Center, Durham
Low Dose Aspirin for the Prevention of Postpartum Related Breast Cancer
RecruitingPhase 2Healthy volunteers welcome
- University of North Carolina, Chapel Hill · 10 mi away
A Study of Alisertib in Combination With Endocrine Therapy in Patients With HR-positive, HER2-negative Recurrent or Metastatic Breast Cancer
RecruitingPhase 2
- UNC Hospitals, University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Radiation Therapy and Thymus Function in Young Women With Breast Cancer
RecruitingObservational study
- Duke Cancer Center, Durham
BGB-43395 Alone or as Part of Combination Therapies in Participants With Breast Cancer and Other Advanced Solid Tumors
RecruitingPhase 1
- Duke Cancer Center, Durham
Evaluation of the Acceptability, Appropriateness, and Feasibility/Usability of a Metastatic Breast-cancer Specific Prognostic Calculator Among Clinicians
RecruitingObservational studyHealthy volunteers welcome
- University of North Carolina, Chapel Hill · 10 mi away
ASPEN-09-03: A Study of Evorpacept in Combination With Trastuzumab and Chemotherapy in Metastatic HER2-Positive Breast Cancer
RecruitingPhase 2
- Duke Cancer Institute, Durham
Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer
RecruitingPhase 3
- Clinical Trial Site, Durham
A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)
RecruitingPhase 3
- University of North Carolina Medical Center, Chapel Hill · 10 mi away
A Study of Imlunestrant (LY3484356) in Premenopausal Women With Estrogen Receptor-Positive (ER+) Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Early Breast Cancer
RecruitingPhase 2
- University of North Carolina Medical Center, Chapel Hill · 10 mi away
A Study of LY4337713 in Participants With FAP-Positive Solid Tumors
RecruitingPhase 1
- Duke University Medical Center, Durham
Evolutionary Clinical Trial for Novel Biomarker-Driven Therapies
RecruitingPhase 2
- Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill, Chapel Hill · 10 mi away
Identifying Patterns in the Breath of Individuals With Breast Cancer
RecruitingObservational studyHealthy volunteers welcome
- Duke University Medical Cente, Durham
Pharmacologic Therapies to Mitigate Radiation- Associated Heart Disease
RecruitingPhase 2
- Lineberger Comprehensive Cancer Center at University of North Carolina, Chapel Hill, Chapel Hill · 10 mi away
A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence
RecruitingPhase 3
- Duke Cancer Institute, Durham
Integrating Biological, Clinical, and Behavioral Factors to Improve Breast Cancer Outcomes - Carolina Breast Cancer Study
RecruitingObservational study
- University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancer
RecruitingPhase 1/2
- Duke Cancer Institute, Durham
A Phase 1/1b Study of IAM1363 in HER2 Cancers
RecruitingPhase 1
- Duke Cancer Institute, Durham
Study of ORIC-114 in Patients With Advanced Solid Tumors Harboring an EGFR or HER2 Alteration
RecruitingPhase 1/2
- Duke Cancer Institute, Durham
Ultra Hypo-fractionated Adjuvant Whole Breast Radiation Therapy With Simultaneous Integrated Boost for Early-Stage Breast Cancer (H-ASSIST)
RecruitingPhase 2
- University of North Carolina, Chapel Hill · 10 mi away
Toci +/- SOC Chemo for Metastatic Triple Negative and ER-positive, HER2-negative Breast Cancers
RecruitingPhase 2
- Duke University, Durham
A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer
RecruitingPhase 3
- Duke Cancer Institute, Durham
Molecular Residual Disease Assessment in a Representative Diverse Population of Patients With Early-stage Breast Cancer
RecruitingHealthy volunteers welcome
- UNC Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
The Vanguard Study: Testing a New Way to Screen for Cancer
RecruitingHealthy volunteers welcome
- Durham VA Medical Center, Durham
- UNC Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
RecruitingPhase 3
- Duke University Medical Center, Durham
- UNC Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
- University of North Carolina-Hillsborough Campus, Hillsborough · 13 mi away
TReatment of ADC-Refractory Breast CancEr With Dato-DXd or T-DXd: TRADE DXd
RecruitingPhase 2
- University of North Carolina, Chapel Hill · 10 mi away
Optimizing Surgical Decisions in Young Adults With Breast Cancer
Recruiting
- Duke Cancer Institute, Durham
A Novel Approach Utilizing Organ Specific Age Proteomics
RecruitingObservational study
- University of North Carolina, Chapel Hill · 10 mi away
Weight Management After Cancer for Survivors in Rural Communities
Recruiting
- Duke University Medical Center, Durham
Behavioral Pain Intervention for Older Cancer Patients
Recruiting
- Duke Cancer Network, Durham
A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01)
RecruitingPhase 2/3
- Duke Cancer Institute, Durham
Axillary Radiotherapy or Axillary Lymph Node Dissection in Patients With Clinically Node- Positive Breast Cancer Undergoing Upfront Tailored Axillary Surgery
Recruiting
- Duke University/Duke Cancer Center, Durham
DATO-BASE: DATOpotamab-deruxtecan for Breast Cancer Brain metAstaSEs
RecruitingPhase 2
- Duke University Medical Center, Durham
Planning Grant for TOPS for Breast Cancer Survivors
Recruiting
- Duke University, Durham
Study of Autologous CAR-T Cells Targeting B7-H3 in TNBC iC9-CAR.B7-H3 T Cells
RecruitingPhase 1
- University of North Carolina, Chapel Hill · 10 mi away
PROGRESS: Precision Oncology Using Genomic Reflexive Evaluations for Study Selection and Survival
Recruiting
- Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill · 10 mi away
A Study of a Decision Tool for People Considering Breast Reconstruction Surgery
Recruiting
- Duke Cancer Institute (Data collection only), Durham
- Duke Cancer Institute (Data collection only), Durham
Correlation of Molecular Markers With Response to Therapy and Breast Cancer Behavior
RecruitingObservational study
- Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill, Chapel Hill · 10 mi away
Evaluation of Lasofoxifene Combined With Abemaciclib Compared With Fulvestrant Combined With Abemaciclib in Locally Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation
RecruitingPhase 3
- Duke University Medical Center, Durham
CD40 Agonist, Flt3 Ligand, and Chemotherapy in HER2 Negative Breast Cancer
RecruitingPhase 1
- University of North Carolina, Chapel Hill · 10 mi away
Translation of Acoustic Angiography: Contrast Enhanced Super Resolution (CESR) Imaging
RecruitingPhase 2Healthy volunteers welcome
- The University of North Carolina, Chapel Hill · 10 mi away
VisR Ultrasound for Noninvasively Interrogating Stromal Collagen Organization in Women as a Breast Cancer Biomarker: Evaluation of Anisotropy in Cancer Patients
RecruitingObservational study
- University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Compare Adjuvant Monotherapy With Endocrine or Accelerated Partial Breast Irradiation After Lumpectomy
RecruitingPhase 2
- University of North Carolina, Chapel Hill · 10 mi away
Promoting Resilience in Women With Breast Cancer (PRISM -MBC)
Recruiting
- University of North Carolina, Chapel Hill · 10 mi away
Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline During Chemotherapy in Breast Cancer
RecruitingPhase 2
- Lineberger Comprehensive Cancer Center at University of North Carolina, Chapel Hill, Chapel Hill · 10 mi away
Sacituzumab Govitecan +/- Pembrolizumab in Metastatic TNBC
RecruitingPhase 2
- The University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Preoperative Chemotherapy, Pembrolizumab and Low or High Dose RADiation in an Expansion Cohort of Node(+), Triple Negative Breast Cancer
RecruitingPhase 2
- University of North Carolina, Chapel Hill · 10 mi away
PREDICT-RD: ctDNA Surveillance in TNBC With Residual Disease
RecruitingPhase 2
- UNC Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
SDM POSSIBLE: A Breast Cancer Treatment Decision Aid for Women 70+ With Low-Risk Stage I Breast Cancers
Recruiting
- Duke University, Durham
Open-Label Study to Evaluate the Safety, Tolerability, PK, and Efficacy of INX-315 in Patients With Advanced Cancer
RecruitingPhase 1/2
- Duke Cancer Center/ DUMC, Durham
PAS 1ml Magtrace® for Sentinel Lymph Node Biopsy in Breast Cancer Patients
RecruitingObservational study
- UNC, Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
A Study of Enzalutamide, Enzalutamide in Combination With Mifepristone, or Chemotherapy in People With Metastatic Breast Cancer
RecruitingPhase 2
- University of North Carolina, Chapel Hill · 10 mi away
A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation
RecruitingPhase 1
- Duke Cancer Institute, Durham
Nutrition Awareness Among Women With Non-Metastatic Breast Cancer
Recruiting
- UNC Cancer Hospital, Chapel Hill · 10 mi away
Harnessing Analysis RNA Expression and Molecular Subtype to Optimize Novel TherapY MBCA
Recruiting
- UNC Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
Symptom Management and Transitioning to Engagement With Post-treatment Care for Adolescent and Young Adult Cancer Survivors
Recruiting
- Duke Cancer Institute, Durham
Feasibility of Symptom Management for Patients With Metastatic Breast Cancer to Increase Exercise
Recruiting
- Lineberger Comphrehensive Cancer Center at University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
BREAST Choice Decision Tool R21 - AIM2
RecruitingHealthy volunteers welcome
- The University of North Carolina, Chapel Hill · 10 mi away
Targeted Palliative Care Intervention for Patients With Metastatic Breast Cancer
Recruiting
- Duke University, Durham
SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
RecruitingObservational study
- Massive Bio SYNERGY-AI site, Chapel Hill · 10 mi away
UNC Pleural Fluid Registry
RecruitingObservational study
- UNC Lingeberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
About Breast Cancer
Breast cancer is a cancer that starts in the breast tissue, when cells change and grow out of control. These extra cells can form a mass called a tumor.
More about Breast Cancer on MedlinePlus
Breast Cancer trials in other cities
- New York City, NY134 studies
- Houston, TX126 studies
- Boston, MA111 studies
- Nashville, TN80 studies
- Los Angeles, CA72 studies
- Edison, NJ68 studies
- St. Louis, MO64 studies
- Queens, NY63 studies
- Chicago, IL58 studies
- Philadelphia, PA56 studies
- Dallas, TX55 studies
- Baltimore, MD47 studies
Other studies in Durham
- Cancer (all types)58 studies
- Non-Small Cell Lung Cancer39 studies
- Multiple Myeloma37 studies
- Metastatic Cancer33 studies
- Acute Myeloid Leukemia33 studies
- Lung Cancer32 studies
- Prostate Cancer32 studies
- Colorectal Cancer28 studies
- Chronic Lymphocytic Leukemia27 studies
- Ovarian Cancer27 studies
- Heart Failure26 studies
- Pancreatic Cancer24 studies
From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.