🔎 Trials Near Me

Home › Head and Neck Cancer › Massachusetts › Boston

Head and Neck Cancer clinical trials in Boston, MA

22 studies for Head and Neck Cancer are looking for participants at sites in and around Boston (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2
  • Massachusetts General Hospital, Boston
  • Dana Farber Cancer Institute, Boston
Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750

FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC

RecruitingPhase 2/3
  • Site #0131, Boston
  • Site#0101, Boston
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06788990

Distance-Based Exercise to Preserve Function and Prevent Disability

Recruiting
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT07059884

A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors

RecruitingPhase 1
  • Brigham and Women's Hospital, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT07090499

First in Human Study of TUB-030 in Patients With Advanced Solid Tumors

RecruitingPhase 1/2
  • Massachusetts General Hospital, Boston
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT06657222

Toripalimab With Chemotherapy for Sinus Cancer

RecruitingPhase 2
  • Brigham and Women's Hospital, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Aug 31, 2026 · NCT06940180

PD-L1 t-haNK, NAI IL-15sa and Cetuximab for Recurrent, Metastatic HNSCC

RecruitingPhase 2
  • Brigham and Women's Hospital, Boston
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT06239220

A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • Massachusetts General Hospital Cancer Center, Boston
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT05592626

Jump: MR Simulation For Radiation Therapy Master Protocol

Recruiting
  • Brigham and Women Hospital, Boston
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Jul 20, 2026 · NCT04545957

PDT For Induction Therapy For Head And Neck Cancer

RecruitingPhase 2
  • Massachusetts General Hospital, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Jul 14, 2026 · NCT07214987

First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • Massachusetts General Hospital, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Jul 7, 2026 · NCT05768139

Clonal Hematopoiesis Chemotherapy and Radiation Effects Study

RecruitingObservational study
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Jun 30, 2026 · NCT07675967

Phase 1/2 Study of ETX-636 in Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • Beth Israel Deaconess Medical Center, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Jun 23, 2026 · NCT06993844

Preoperative Pembrolizumab and Chemotherapy in Resectable, Recurrent HNSCC

RecruitingPhase 2
  • Brigham and Women's Hospital, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Jun 23, 2026 · NCT05726370

A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements

RecruitingPhase 1/2
  • Massachusetts General Hospital,, Boston
Ages 12 and older · All sexes · Updated May 27, 2026 · NCT03093116

Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors

RecruitingPhase 1/2
  • Massachusetts General Hospital, Boston
Ages 18 and older · All sexes · Updated May 6, 2026 · NCT06239194

Study of De_Intensified Postoperative Radiation Therapy for HPV Associated Oropharyngeal Squamous Cell Carcinoma

Recruiting
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Mar 13, 2026 · NCT03875716

Stereotactic MRI-guided Focused Ultrasound Mesencephalotomy

Recruiting
  • Brigham and Women's Hospital, Boston
Ages 18 to 85 · All sexes · Updated Feb 12, 2026 · NCT07405645

Drug Screening Using Novel IMD in Salivary and Head and Neck Cancers

RecruitingEarly phase 1
  • Brigham and Women's Hospital, Boston
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Jan 26, 2026 · NCT05553782

A Study to Evaluate TROP2 ADC LCB84 Single Agent and in Combination With an Anti-PD-1 Ab in Advanced Solid Tumors

RecruitingPhase 1/2
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Sep 24, 2025 · NCT05941507

Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors

RecruitingPhase 1
  • Dana Farber/Partners Cancer Care Inc, Boston
Ages 18 and older · All sexes · Updated Aug 15, 2025 · NCT04429542

Comprehensive Outcomes for After Cancer Health

RecruitingHealthy volunteers welcome
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Dec 11, 2024 · NCT05349227

About Head and Neck Cancer

Head and neck cancer includes cancers of the mouth, nose, sinuses, salivary glands, throat, and lymph nodes. Read the different symptoms of each type.

More about Head and Neck Cancer on MedlinePlus

Head and Neck Cancer trials in other cities

Other studies in Boston

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.