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Non-Small Cell Lung Cancer clinical trials in Springfield, IL
13 studies for Non-Small Cell Lung Cancer are looking for participants at sites in and around Springfield (within about 30 miles). Open a study to see who can join and how to contact the study team.
Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →
Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])
RecruitingPhase 3
- Southern Illinois University School of Medicine, Springfield
- Springfield Clinic, Springfield
Testing the Impact of an Anti-Cancer Drug, Atezolizumab, After Surgery to Prevent Early Stage Non-small Cell Lung Cancer From Returning, AASI-NSCLC Trial
RecruitingPhase 3
- Southern Illinois University School of Medicine, Springfield
- Springfield Clinic, Springfield
- Springfield Memorial Hospital, Springfield
Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer
RecruitingPhase 3
- Springfield Clinic Main Campus, Springfield
Testing Osimertinib as a Treatment for Lung Cancers With an EGFR Exon 20 Change
RecruitingPhase 2
- Southern Illinois University School of Medicine, Springfield
- Springfield Clinic, Springfield
- Springfield Memorial Hospital, Springfield
A Study to Assess Adverse Events and How Intravenously (IV) Infused Telisotuzumab Vedotin (ABBV-399) Moves Through the Body as a Monotherapy in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
RecruitingPhase 2
- Springfield Clinic - First /ID# 272576, Springfield
A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)
RecruitingPhase 3
- Springfield Clinic Main Campus, Springfield
A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer
RecruitingPhase 3
- Springfield Clinic Main Campus, Springfield
A Study of Sigvotatug Vedotin in Advanced Solid Tumors
RecruitingPhase 1
- Southern Illinois University - Simmons Cancer Institute, Springfield
- Springfield Clinic Radiology - 800 Building, Springfield
- Springfield Clinic Urgent Care Plus, Springfield
- and 4 more
Comparing Combinations of Targeted Drugs for Advanced Non-Small Cell Lung Cancer That Has EGFR and MET Gene Changes (A Lung-MAP Treatment Trial)
RecruitingPhase 2
- Southern Illinois University School of Medicine, Springfield
- Springfield Clinic, Springfield
- Springfield Memorial Hospital, Springfield
Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has Increased Copies of the MET Gene (An Expanded Lung-MAP Treatment Trial)
RecruitingPhase 2
- Southern Illinois University School of Medicine, Springfield
- Springfield Clinic, Springfield
- Springfield Memorial Hospital, Springfield
Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)
RecruitingPhase 2
- Southern Illinois University School of Medicine, Springfield
- Springfield Clinic, Springfield
- Springfield Memorial Hospital, Springfield
Adding the Immunotherapy Drug Cemiplimab to Usual Treatment for People With Advanced Non-Small Cell Lung Cancer Who Had Previous Treatment With Platinum Chemotherapy and Immunotherapy (An Expanded Lung-MAP Treatment Trial)
RecruitingPhase 2/3
- Southern Illinois University School of Medicine, Springfield
- Springfield Clinic, Springfield
- Springfield Memorial Hospital, Springfield
Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics
RecruitingObservational study
- Southern Illinois University School of Medicine, Springfield
- Springfield Clinic, Springfield
- Springfield Memorial Hospital, Springfield
Non-Small Cell Lung Cancer trials in other cities
- Houston, TX145 studies
- New York City, NY120 studies
- Arlington, VA104 studies
- Nashville, TN97 studies
- Boston, MA90 studies
- Los Angeles, CA87 studies
- St. Louis, MO73 studies
- Chicago, IL61 studies
- Baltimore, MD60 studies
- San Antonio, TX59 studies
- Columbus, OH56 studies
- Washington, DC55 studies
Other studies in Springfield
- Lung Cancer12 studies
- Colorectal Cancer9 studies
- Acute Myeloid Leukemia8 studies
- Breast Cancer8 studies
- Head and Neck Squamous Cell Carcinoma6 studies
- Kidney Cancer (Renal Cell Carcinoma)6 studies
- Prostate Cancer6 studies
- Cancer (all types)6 studies
- Bladder Cancer6 studies
- Pancreatic Cancer5 studies
- Melanoma5 studies
- Multiple Myeloma4 studies
From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.