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Bladder Cancer clinical trials in Cleveland, OH

18 studies for Bladder Cancer are looking for participants at sites in and around Cleveland (within about 30 miles). Open a study to see who can join and how to contact the study team.

Symbiotic-GU-06: A Study to Learn About PF-08634404 Alone or In Combination With Enfortumab Vedotin in Urothelial Cancer

RecruitingPhase 1/2
  • University Hospitals Cleveland Medical Center, Cleveland
  • Cleveland Clinic Foundation, Cleveland
  • Cleveland Clinic Taussig Cancer Center Investigational Pharmacy, Cleveland
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07421700

Combining Immunotherapy and Radiation Therapy to Help Patients Avoid Bladder Removal After Treatment Shrinks Muscle Invasive Bladder Cancer, BRIGHT Trial

RecruitingPhase 2
  • MetroHealth Medical Center, Cleveland
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT07061964

A Study Evaluating the Safety, Efficacy, and Pharmacokinetics (PK) of EVOLVE104 in Participants With Advanced Urothelial and Squamous Cell Carcinomas

RecruitingPhase 1
  • University Hospitals Cleveland Medical Center, Cleveland
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT07217171

ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation

RecruitingObservational study
  • Cleveland Clinic, Cleveland
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT05059444

A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

RecruitingPhase 1
  • University Hospitals Cleveland Medical Center, Cleveland
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT06465069

Phase 2 Study to Evaluate Safety and Efficacy of Cretostimogene Grenadenorepvec in High-Risk NMIBC

RecruitingPhase 2
  • Cleveland Clinic, Cleveland
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT06567743

The Vanguard Study: Testing a New Way to Screen for Cancer

RecruitingHealthy volunteers welcome
  • Louis Stokes Cleveland VA Medical Center, Cleveland
Ages 45 to 75 · All sexes · Updated Sep 2, 2026 · NCT06995898

KEYMAKER-U04 Substudy 04D: A Clinical Study of New Treatments Given With Enfortumab Vedotin and Pembrolizumab in People With Urothelial Cancer (MK-3475-04D/KEYMAKER-U04)

RecruitingPhase 1/2
  • Cleveland Clinic Taussig Cancer ( Site 5036), Cleveland
Ages 18 and older · All sexes · Updated Sep 1, 2026 · NCT07232602

Safety and Efficacy Study of Intravesical Instillation of TARA-002 in Adults With High-grade Non-muscle Invasive Bladder Cancer

RecruitingPhase 2
  • Cleveland Clinic Main Campus, Cleveland, Cleveland
Ages 18 and older · All sexes · Updated Aug 24, 2026 · NCT05951179

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients Receiving the Usual Chemotherapy Treatment for Bladder Cancer, ARCHER Study

RecruitingPhase 3
  • Case Western Reserve University, Cleveland
  • UHHS-Chagrin Highlands Medical Center, Beachwood · 10 mi away
  • UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor · 22 mi away
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT07097142

Phase 2/3 Trial of Izalontamab Brengitecan vs Platinum-based Chemotherapy for Metastatic Urothelial Cancer With Disease Progression on or After Immunotherapy

RecruitingPhase 2/3
  • Fairview Hospital, Cleveland
  • Cleveland Clinic, Cleveland
  • Cleveland Clinic - Hillcrest Hospital, Mayfield Heights · 12 mi away
Ages 18 and older · All sexes · Updated Jul 29, 2026 · NCT07106762

An Open-label Study to Investigate the Efficacy and Safety of Dato-DXd + Rilvegostomig vs SoC in Adult Participants With High-risk MIUC

RecruitingPhase 3
  • Research Site, Cleveland
Ages 18 and older · All sexes · Updated Jul 22, 2026 · NCT07720284

A Study of Disitamab Vedotin Alone or With Pembrolizumab in Urothelial Cancer That Expresses HER2

RecruitingPhase 2
  • University Hospitals Cleveland Medical Center, Cleveland
Ages 18 and older · All sexes · Updated Jul 22, 2026 · NCT04879329

Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2
  • Cleveland Clinic, Cleveland
Ages 18 and older · All sexes · Updated Feb 18, 2026 · NCT07030257

cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

RecruitingObservational studyHealthy volunteers welcome
  • Cleveland Clinic, Cleveland
Ages 40 and older · All sexes · Updated Jan 20, 2026 · NCT05366881

Futibatinib in Combination With Durvalumab Prior to Cystectomy for the Treatment of Muscle-Invasive Bladder Cancer Patients Who Are Ineligible for Cisplatin-based Therapy

RecruitingPhase 2
  • Cleveland Clinic Taussig Cancer Center, Cleveland
Ages 18 and older · All sexes · Updated Dec 17, 2025 · NCT06263153

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Mayfield Heights · 12 mi away
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

About Bladder Cancer

Bladder cancer symptoms range from lower back pain to blood in your urine. Read about important risk factors and find a list of treatments available

More about Bladder Cancer on MedlinePlus

Bladder Cancer trials in other cities

Other studies in Cleveland

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.