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Down Syndrome clinical trials recruiting in the U.S.

39 studies for Down Syndrome are recruiting participants at sites across the United States.

About 1 in 700 babies are born with the birth defect known as Down Syndrome. Learn about the different Down Syndrome types and related health issues.

Cities with the most studies

• Aurora, CO7 studies
• Durham, NC6 studies
• Houston, TX6 studies
• Phoenix, AZ6 studies
• Kansas City, KS5 studies
• Philadelphia, PA5 studies
• Cleveland, OH5 studies
• Nashville, TN5 studies
• Ann Arbor, MI5 studies
• Cincinnati, OH5 studies
• Orlando, FL5 studies
• Orange, CA4 studies
• San Antonio, TX4 studies
• Madison, WI4 studies
• Pittsburgh, PA4 studies
• St. Louis, MO4 studies
• Seattle, WA4 studies
• Atlanta, GA4 studies
• San Diego, CA4 studies
• Birmingham, AL4 studies
• Portland, OR4 studies
• Las Vegas, NV4 studies
• Memphis, TN3 studies
• Minneapolis, MN3 studies
• Baltimore, MD3 studies
• Knoxville, TN3 studies
• Tampa, FL3 studies
• Grand Rapids, MI3 studies
• Chicago, IL3 studies
• Los Angeles, CA3 studies
• Columbus, OH3 studies
• Norfolk, VA3 studies
• Dallas, TX3 studies
• Austin, TX3 studies

By state

• Alabama4 studies
• Arizona7 studies
• California10 studies
• Colorado8 studies
• Florida9 studies
• Georgia4 studies
• Illinois5 studies
• Kansas5 studies
• Maryland4 studies
• Massachusetts4 studies
• Michigan7 studies
• Minnesota3 studies
• Missouri4 studies
• Nevada4 studies
• New Jersey3 studies
• New York5 studies
• North Carolina8 studies
• Ohio8 studies
• Oregon4 studies
• Pennsylvania6 studies
• South Carolina3 studies
• Tennessee8 studies
• Texas9 studies
• Virginia3 studies
• Washington4 studies
• Wisconsin4 studies

Recently updated studies

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.