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Head and Neck Squamous Cell Carcinoma clinical trials in Columbus, OH

18 studies for Head and Neck Squamous Cell Carcinoma are looking for participants at sites in and around Columbus (within about 30 miles). Open a study to see who can join and how to contact the study team.

A Study of Amivantamab in Addition to Standard of Care Agents (SOC) Compared With SOC Alone in Participants With Recurrent/Metastatic Head and Neck Cancer

RecruitingPhase 3
  • Ohio State University, Columbus
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07276399

Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

RecruitingPhase 2
  • Ohio State University Comprehensive Cancer Center, Columbus
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT02734537

Study of Volrustomig as Monotherapy or in Combination With Anti- Cancer Agents in Participants With Advanced/Metastatic Solid Tumors

RecruitingPhase 2
  • Research Site, Columbus
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT06535607

First in Human Study of TUB-030 in Patients With Advanced Solid Tumors

RecruitingPhase 1/2
  • Ohio State University, Columbus
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT06657222

A Longitudinal Multi-Omic Biomarker Profiling Study of Patients With Head & Neck Squamous Cell Carcinoma (HNSCC)

RecruitingObservational study
  • Ohio State University, Columbus
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT06163534

A Study to See if Giving Fianlimab and Cemiplimab Together is Better Than Cemiplimab Alone at Treating Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

RecruitingPhase 2
  • Ohio State University, Columbus
Ages 18 and older · All sexes · Updated Aug 21, 2026 · NCT06769698

Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer

RecruitingPhase 2/3
  • Ohio State University Comprehensive Cancer Center, Columbus
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT04333537

Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer

RecruitingPhase 2
  • Ohio State University Comprehensive Cancer Center, Columbus
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT06532279

Study to Assess GTAEXS617 in Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • The Ohio State University, Columbus
Ages 18 and older · All sexes · Updated Aug 13, 2026 · NCT05985655

SMP-3124LP in Adults With Advanced Solid Tumors

RecruitingPhase 1/2
  • Ohio State University, Columbus
Ages 18 and older · All sexes · Updated Aug 12, 2026 · NCT06526819

A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors

RecruitingPhase 1/2
  • Ohio State University, Columbus
Ages 18 and older · All sexes · Updated Jul 29, 2026 · NCT03526835

Combining Immunotherapy Salvage Surgery & IORT Tx Persistent/Recurrent Head & Neck Cancer

RecruitingPhase 1
  • Ohio State University Comprehensive Cancer Center, Columbus
Ages 18 and older · All sexes · Updated Jul 24, 2026 · NCT04754321

First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • Stefanie Spielman Comprehensive Breast Center, Columbus
Ages 18 and older · All sexes · Updated Jul 7, 2026 · NCT05768139

A Study of Ficlatuzumab in Combination With Cetuximab in Participants With Recurrent or Metastatic (R/M) HPV Negative Head and Neck Squamous Cell Carcinoma

RecruitingPhase 3
  • Ohio State University, James Cancer Hospital and Solove Research Institute, Columbus
Ages 18 and older · All sexes · Updated Apr 9, 2026 · NCT06064877

Adaptive De-intensified Radiotherapy Using Circulating Tumor DNA in HPV- Associated Oropharyngeal Cancer

RecruitingPhase 2
  • Ohio State University Comprehensive Cancer Center, Columbus
Ages 18 and older · All sexes · Updated Mar 24, 2026 · NCT06323460

Transoral Robotic Surgery in Treating Patients With Benign or Malignant Tumors of the Head and Neck

Recruiting
  • Ohio State University Medical Center, Columbus
Ages 18 and older · All sexes · Updated Feb 10, 2026 · NCT01473784

A Study of MT-4561 in Patients With Various Advanced Solid Tumors

RecruitingPhase 1/2
  • The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer Center, Columbus
Ages 18 and older · All sexes · Updated Dec 11, 2025 · NCT06943521

A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression

RecruitingPhase 1/2
  • The Ohio State University, Columbus
Ages 18 and older · All sexes · Updated Sep 9, 2025 · NCT06682793

Head and Neck Squamous Cell Carcinoma trials in other cities

Other studies in Columbus

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.