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Prostate Cancer clinical trials in Columbus, OH

24 studies for Prostate Cancer are looking for participants at sites in and around Columbus (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Testing the Addition of Docetaxel (Chemotherapy) to the Usual Treatment (Hormonal Therapy and Apalutamide) for Metastatic Prostate Cancer, ASPIRE Trial

RecruitingPhase 3
  • Ohio State University Comprehensive Cancer Center, Columbus
Ages 18 and older · Men · Updated Oct 2, 2026 · NCT06931340

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • Ohio State University Comprehensive Cancer Center, Columbus
  • Mount Carmel East Hospital, Columbus
  • The Mark H Zangmeister Center, Columbus
  • and 8 more
Ages 40 to 75 · All sexes · Updated Oct 2, 2026 · NCT05334069

Targeted Treatment for Metastatic Prostate Cancer, The PREDICT Trial

RecruitingPhase 2
  • Ohio State University Comprehensive Cancer Center, Columbus
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06632977

Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

RecruitingPhase 2
  • Ohio State University Comprehensive Cancer Center, Columbus
  • Mount Carmel East Hospital, Columbus
  • Columbus Oncology and Hematology Associates Inc, Columbus
  • and 11 more
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT03866382

A Study of Xaluritamig Plus Abiraterone Versus Investigator's Choice in Participants With Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer

RecruitingPhase 3
  • The Ohio State University, Columbus
Ages 18 and older · Men · Updated Sep 22, 2026 · NCT07213674

Study Comparing AAA817+ARPI Versus Standard of Care in Adult Participants With PSMA-positive mCRPC

RecruitingPhase 3
  • Central Ohio Urology Group, Gahanna · 7 mi away
Ages 18 to 100 · Men · Updated Sep 22, 2026 · NCT06855277

A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA Mutation

RecruitingPhase 3
  • Research Site, Columbus
Ages 18 and older · Men · Updated Sep 18, 2026 · NCT06952803

A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)

RecruitingPhase 3
  • The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C ( Site 0061), Columbus
Ages 18 and older · Men · Updated Sep 17, 2026 · NCT06925737

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

RecruitingPhase 3
  • Ohio State University Comprehensive Cancer Center, Columbus
  • Riverside Methodist Hospital, Columbus
  • Grant Medical Center, Columbus
  • and 4 more
Ages 18 and older · Men · Updated Sep 10, 2026 · NCT05946213

A Phase 1b/2a Study of Pocenbrodib as Monotherapy and in Combination With Darolutamide in Participants With mCRPC

RecruitingPhase 1/2
  • The Ohio State University, Columbus
Ages 18 and older · Men · Updated Aug 20, 2026 · NCT06785636

Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging

RecruitingPhase 3
  • Ohio State University Comprehensive Cancer Center, Columbus
Ages 18 and older · Men · Updated Aug 19, 2026 · NCT04423211

Study of JANX007 in Subjects With Metastatic Castration-Resistant Prostate Cancer (ENGAGER-PSMA-01)

RecruitingPhase 1
  • The Ohio State University, Columbus
Ages 18 to 100 · Men · Updated Aug 13, 2026 · NCT05519449

Evaluation of Neoadjuvant Xaluritamig in Localized Prostate Cancer

RecruitingPhase 1
  • The Ohio State University, Columbus
Ages 18 and older · Men · Updated Jul 31, 2026 · NCT06613100

Docetaxel to Androgen Receptor Pathway Inhibitors in Patients With Metastatic Castration Sensitive Prostate Cancer and Suboptimal PSA Response

RecruitingPhase 3
  • Ohio State University Comprehensive Cancer Center, Columbus
Ages 18 and older · Men · Updated Jul 14, 2026 · NCT06592924

Testing the Safety and Effectiveness of Radiation-based Treatment (Lutetium Lu 177 Dotatate) for Metastatic Prostate Cancer That Has Neuroendocrine Cells

RecruitingPhase 2
  • Ohio State University Comprehensive Cancer Center, Columbus
Ages 18 and older · Men · Updated Jul 14, 2026 · NCT05691465

A Clinical Study of KTX-2001 in Subjects With Metastatic Castration-Resistant Prostate Cancer (STRIKE-001)

RecruitingPhase 1
  • The Ohio State University Comprehensive Cancer Center, Columbus
Ages 18 and older · Men · Updated Jul 9, 2026 · NCT07103018

Study of CX-5461 in Patients With Solid Tumours and BRCA1/2, PALB2 or Homologous Recombination Deficiency (HRD) Mutation

RecruitingPhase 1
  • Ohio State University-James Cancer Hospital and Solove Research Institute, Columbus
Ages 18 and older · All sexes · Updated Jun 8, 2026 · NCT04890613

A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies

RecruitingPhase 1/2
  • Stefanie Spielman Comprehensive Breast Center, Columbus
Ages 18 and older · All sexes · Updated Mar 27, 2026 · NCT06395519

Effects of Relugolix vs Leuprolide on Cardiac Function in Patients With Prostate Cancer

RecruitingPhase 2
  • Ohio State University Comprehensive Cancer Center, Columbus
Ages 18 and older · Men · Updated Mar 9, 2026 · NCT06330805

A Study of MT-4561 in Patients With Various Advanced Solid Tumors

RecruitingPhase 1/2
  • The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer Center, Columbus
Ages 18 and older · All sexes · Updated Dec 11, 2025 · NCT06943521

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Columbus
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer

RecruitingPhase 3
  • Ohio State University Comprehensive Cancer Center, Columbus
Ages 18 and older · Men · Updated Sep 11, 2025 · NCT03678025

FK-PC101 as Adjuvant Therapy for Men With High-Risk Prostate Cancer

RecruitingPhase 2
  • Central Ohio Urology Group, Gahanna · 7 mi away
All ages · Men · Updated Oct 21, 2024 · NCT06636682

About Prostate Cancer

Prostate cancer is one of the most common types of cancer among American men. The risk goes up as men age. Learn about symptoms, tests, and treatment.

More about Prostate Cancer on MedlinePlus

Prostate Cancer trials in other cities

Other studies in Columbus

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.