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Lung Cancer clinical trials in Orlando, FL

21 studies for Lung Cancer are looking for participants at sites in and around Orlando (within about 30 miles). Open a study to see who can join and how to contact the study team.

Neladalkib (NVL-655) for TKI-naive Patients With Advanced ALK-Positive NSCLC

RecruitingPhase 3
  • AdventHealth Cancer Institute, Orlando
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT06765109

A Clinical Study of MK-1084 With Other Treatments for Non-small Cell Lung Cancer (MK-3475-01F)

RecruitingPhase 1/2
  • Clermont Oncology Center ( Site 0041), Clermont · 24 mi away
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07286149

Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

RecruitingPhase 3
  • Florida Cancer Specialists, Orlando
  • Orlando Health Ambulatory Care Center, Orlando
  • Orlando Health Cancer Institute, Orlando
  • and 4 more
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07222566

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 2
  • AdventHealth Medical Group Oncology Research at Celebration, Kissimmee · 16 mi away
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06172478

Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and Other Investigational Agents for Lung Cancer

RecruitingPhase 2/3
  • Clermont Oncology Center, Clermont · 24 mi away
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06712316

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2
  • Advent Health, Orlando
Ages 12 and older · All sexes · Updated Sep 15, 2026 · NCT04585750

Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid Tumors

RecruitingPhase 1
  • Sarah Cannon Research Institute - Lake Nona Florida, Orlando
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06293898

A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

RecruitingPhase 3
  • Orlando Health Cancer Institute, Orlando
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT06119581

AVENTINE-1: Study of AVZO-1418 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Solid Tumors (AVZO-1418-1001)

RecruitingPhase 1/2
  • Avenzo Therapeutics Recruiting Site, Orlando
Ages 18 to 75 · All sexes · Updated Sep 4, 2026 · NCT07038343

Evaluation of the Safety and Efficacy of Abenacianine (VGT-309) to Identify Cancer in Subjects Undergoing Surgery for Cancer in the Lung

RecruitingPhase 3
  • Orlando Health Cancer Center, Orlando
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT07499674

Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-Small Cell Lung Cancer

RecruitingPhase 3
  • Orlando Health Cancer Institute, Orlando
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT05624996

A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • AdventHealth Celebration, Celebration · 17 mi away
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT05592626

Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist)

RecruitingPhase 1/2
  • Clermont Oncology Center, Clermont · 24 mi away
Ages 18 and older · All sexes · Updated Jul 29, 2026 · NCT04198766

Safety and Efficacy of OBX-115 in Advanced Solid Tumors

RecruitingPhase 1/2
  • Orlando Health Cancer Institute (Melanoma/NSCLC), Orlando
Ages 18 and older · All sexes · Updated Jul 16, 2026 · NCT06060613

A Study to Investigate the Efficacy and Safety of an Infusion of IOV-4001 in Adult Participants With Unresectable or Metastatic Melanoma or Stage III or IV Non-small-cell Lung Cancer

RecruitingPhase 1/2
  • Orlando Health Cancer Institute, Orlando
Ages 18 to 70 · All sexes · Updated Jun 11, 2026 · NCT05361174

A Study to Learn About Study Medicine ALTA3263 in Adults With Advanced Solid Tumors With KRAS Mutations

RecruitingPhase 1
  • Research Site, Orlando
Ages 18 and older · All sexes · Updated Jun 10, 2026 · NCT06835569

A Phase 1 Study of CPO301 in Adult Patients With Advanced or Metastatic Solid Tumors

RecruitingPhase 1
  • AdventHealth Cancer Institute, Celebration · 17 mi away
Ages 18 and older · All sexes · Updated Mar 20, 2026 · NCT05948865

A Study to Evaluate the Safety, Pharmacokinetics and Efficacy of TJ101 in Patients With Advanced/Metastatic Solid Tumors

RecruitingPhase 1
  • Florida Cancer Specialists & Research Institute, Orlando
Ages 18 and older · All sexes · Updated Jan 12, 2026 · NCT07181473

Building on Trust: Navigating Preventive Lung, Breast, and Prostate Cancer Screenings at Community Resource Spots

RecruitingObservational studyHealthy volunteers welcome
  • Adventhealth, Orlando
Ages 18 and older · All sexes · Updated Nov 17, 2025 · NCT07231159

Clinical Validation of Freenome Multiomics Blood Test for Lung Cancer Screening

RecruitingObservational study
  • Charter Research, Winter Park · 5 mi away
  • I.H.S Health, LLC, Kissimmee · 16 mi away
Ages 50 and older · All sexes · Updated Aug 5, 2025 · NCT06122077

Clinical Utility of Management of Patients With Pulmonary Nodules Using the Percepta Nasal Swab Classifier

RecruitingObservational study
  • Orlando VA Healthcare System, Orlando
Ages 29 to 85 · All sexes · Updated Nov 13, 2024 · NCT06426628

About Lung Cancer

Lung cancer forms in tissues of the lung, usually in the cells that line the air passages. It is the leading cause of cancer death in both men and women.

More about Lung Cancer on MedlinePlus

Lung Cancer trials in other cities

Other studies in Orlando

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.