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Obesity clinical trials in Orlando, FL

31 studies for Obesity are looking for participants at sites in and around Orlando (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Safety and Efficacy of ABBV-295 in Adults With Obesity or Overweight With Weight-Related Comorbidities

RecruitingPhase 2
  • Charter Research - Winter Park /ID# 281968, Orlando
  • Florida Institute For Clinical Research /ID# 282739, Orlando
Ages 18 to 75 · All sexes · Updated Oct 2, 2026 · NCT07752979

Comparing the Efficacy and Safety of the EndoZip System and Apollo ESG in Obese Patients

Recruiting
  • Orlando Health, Inc., Orlando
Ages 21 to 65 · All sexes · Updated Oct 1, 2026 · NCT07090005

A Study to Evaluate the Impact of Renal Impairment on the Pharmacokinetics (PK) of Ribupatide

RecruitingPhase 1Healthy volunteers welcome
  • Kailera Clinical Site, Orlando
Ages 18 to 85 · All sexes · Updated Oct 1, 2026 · NCT07793929

A Study of Clazakizumab (LY5724886) in Adults With Elevated hsCRP and at Increased Risk for Cardiovascular Event

RecruitingPhase 2
  • Florida Institute For Clinical Research, LLC, Orlando
  • K2 Medical Research - Maitland, Maitland · 6 mi away
  • Omega Research Orlando, Altamonte Springs · 9 mi away
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT07783802

AMAZE 2: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight

RecruitingPhase 3
  • Florida Institute for Clinical Research, LLC, Orlando
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT07533175

Study of Olatorepatide in Adult Participants Living With Overweight or Obesity Without Diabetes

RecruitingPhase 2
  • Clinical Site Partners, LLC DBA Flourish Research, Winter Park · 5 mi away
  • K2 Medical Research Maitland LLC, Main Office, Maitland · 6 mi away
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT07685808

Study to Assess the Effect and Safety of ALV-100 on Maintenance of Weight Loss

RecruitingPhase 2
  • Clinical Neuroscience Solutions, Orlando
Ages 18 to 75 · All sexes · Updated Sep 28, 2026 · NCT07837973

AMAZE 9: A Research Study Investigating How Well Zenagamtide Tablets Help People With Excess Body Weight Lose Weight

RecruitingPhase 3
  • Clinical Neuroscience Solution, Orlando
  • Florida Institute for Clinical Research, LLC, Orlando
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07720271

A Research Study Investigating How Well the Medicine Zenagamtide Helps People With Excess Body Weight Lose Weight Compared to Semaglutide

RecruitingPhase 3
  • Florida Inst For Clin Res LLC, Orlando
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07668414

Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight

RecruitingPhase 3
  • Orlando Health, Orlando
  • Digestive and Liver Center of Florida, Orlando
Ages 18 to 70 · All sexes · Updated Sep 24, 2026 · NCT06937099

A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)

RecruitingPhase 3
  • Florida Hospital- Center for Pediatric Research, Orlando
  • Nemours Children's Health, Orlando
Ages 6 to 17 · All sexes · Updated Sep 24, 2026 · NCT06672549

Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study

RecruitingPhase 3
  • Orlando Health, Orlando
  • Digestive and Liver Center of Florida, Orlando
Ages 18 to 70 · All sexes · Updated Sep 24, 2026 · NCT06937086

AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight

RecruitingPhase 3
  • Clinical Neuroscience Solution, Orlando
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT07339423

A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, and Type 2 Diabetes

RecruitingPhase 3
  • Clinical Site Partners, LLC dba Flourish Research, Winter Park · 5 mi away
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07282600

A Study to Evaluate Effect of AZD6234 in Adult Participants With Type 2 Diabetes Mellitus and Obesity or Overweight

RecruitingPhase 3
  • Research Site, Ocoee · 10 mi away
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07784270

Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity

RecruitingPhase 3
  • West Orange Endocrinology, Ocoee · 10 mi away
Ages 45 to 99 · All sexes · Updated Sep 22, 2026 · NCT07037433

Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight

RecruitingPhase 3
  • Conquest Research, Winter Park · 5 mi away
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07353931

A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight

RecruitingPhase 2
  • Charter Research - Winter Park, Orlando
Ages 18 to 75 · All sexes · Updated Sep 22, 2026 · NCT07589608

A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities

RecruitingPhase 3
  • AURORA-1 Clinical Site, Winter Park · 5 mi away
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT07743463

A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Type 2 Diabetes

RecruitingPhase 3
  • AURORA-2 Clinical Site, Winter Park · 5 mi away
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT07743450

Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

RecruitingPhase 3
  • AdventHealth Orlando, Orlando
  • Orlando Health Heart Institute, Orlando
  • Guardian Research Organization LLC, Winter Park · 5 mi away
  • and 1 more
Ages 18 to 99 · All sexes · Updated Sep 16, 2026 · NCT07037459

Feasibility and Acceptability of a Pediatric Referral to Summer Day Camps to Treat Obesity in Children From Low-Income Households

Recruiting
  • University of Central Florida, Orlando
Ages 5 to 11 · All sexes · Updated Sep 14, 2026 · NCT07464015

A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)

RecruitingPhase 3Healthy volunteers welcome
  • ACCOMPLISH-2 Research Site, Ocoee · 10 mi away
Ages 18 to 79 · All sexes · Updated Sep 11, 2026 · NCT07654374

A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight

RecruitingPhase 2
  • Charter Research - Winter Park, Orlando
Ages 18 to 75 · All sexes · Updated Sep 8, 2026 · NCT06143956

Efficacy and Safety of Ribupatide Administered Once Weekly in Participants Living With Obesity or Overweight and Diabetes

RecruitingPhase 3
  • Kailera Clinical Site, Orlando
  • Kailera Clinical Site, Orlando
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT07284901

Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-1-EXTENSION)

RecruitingPhase 3
  • Clinical Neuroscience Solutions - Orlando, Orlando
  • Combined Research Orlando Phase I IV, Orlando
  • Florida Institute for Clinical Research, Orlando
Ages 18 to 99 · All sexes · Updated Sep 3, 2026 · NCT07684235

Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-2-EXTENSION)

RecruitingPhase 3
  • Florida Institute for Clinical Research, Orlando
  • Conquest Research - Winter Park, Winter Park · 5 mi away
Ages 18 to 99 · All sexes · Updated Sep 3, 2026 · NCT07684144

Efficacy, Safety and Tolerability of Switching From Glucagon-like Peptide-1 Receptor Agonists (GLP-1RA) to Maridebart Cafraglutide in Adults With Obesity or Overweight (MARITIME-SWITCH)

RecruitingPhase 3
  • Clinical Neuroscience Solutions, Orlando
  • Florida Institute for Clinical Research, Orlando
Ages 18 to 99 · All sexes · Updated Aug 27, 2026 · NCT07575399

A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity

RecruitingPhase 3
  • Cardiovascular Institute of Orlando, Orlando
  • Guardian Research Org LLC, Winter Park · 5 mi away
  • K2 Medical Research, Maitland · 6 mi away
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT07567001

Efficacy and Safety of Aleniglipron in Participants With Obesity or Overweight With a Weight-Related Comorbidity (ACCOMPLISH-1)

RecruitingPhase 3
  • ACCOMPLISH-1 Research Site, Ocoee · 10 mi away
Ages 18 to 79 · All sexes · Updated Aug 10, 2026 · NCT07654361

Assessments of Adipogenesis, Lipid Turnover and Cellular Composition in Adipose Tissue in Response to Endurance Exercise

RecruitingHealthy volunteers welcome
  • AdventHealth Translational Research Institute, Orlando
Ages 18 to 45 · All sexes · Updated Mar 27, 2026 · NCT06602141

About Obesity

Read about the causes of obesity and find out what you can do to decrease your risk of its associated health issues.

More about Obesity on MedlinePlus

Obesity trials in other cities

Other studies in Orlando

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.