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Breast Cancer clinical trials in Orlando, FL

23 studies for Breast Cancer are looking for participants at sites in and around Orlando (within about 30 miles). Open a study to see who can join and how to contact the study team.

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The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2
  • Advent Health, Orlando
Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 2
  • AdventHealth Medical Group Oncology Research at Celebration, Kissimmee · 16 mi away
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06172478

A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016)

RecruitingPhase 3
  • AdventHealth Medical Group Oncology and Hematology at Altamonte ( Site 0024), Altamonte Springs · 9 mi away
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07060807

A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)

RecruitingPhase 3
  • AdventHealth Medical Group Oncology and Hematology at Altamonte ( Site 0044), Altamonte Springs · 9 mi away
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06966700

A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)

RecruitingPhase 3
  • Orlando Health Cancer Institute ( Site 0011), Orlando
  • AdventHealth Altamonte Springs ( Site 0021), Altamonte Springs · 9 mi away
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06312176

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

RecruitingPhase 3
  • AdventHealth Altamonte Springs, Altamonte Springs · 9 mi away
  • Clermont Oncology Center, Clermont · 24 mi away
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07174336

A Study of Imlunestrant (LY3484356) in Premenopausal Women With Estrogen Receptor-Positive (ER+) Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Early Breast Cancer

RecruitingPhase 2
  • AdventHealth Altamonte Springs, Altamonte Springs · 9 mi away
Ages 18 and older · Women · Updated Sep 22, 2026 · NCT07287098

A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations

RecruitingPhase 1/2
  • Florida Cancer Specialists - Lake Nona, Orlando
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07109726

A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence

RecruitingPhase 3
  • AdventHealth Orlando Infusion Center, Orlando
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT06492616

Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid Tumors

RecruitingPhase 1
  • Sarah Cannon Research Institute - Lake Nona Florida, Orlando
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06293898

A Trial to Evaluate Ovarian Suppression Following Subcutaneous ZOLADEX 10.8 mg in Premenopausal Women With Early-stage and Advanced HR+ Breast Cancer

RecruitingPhase 1
  • Cancer Centers of Florida, Ocoee · 10 mi away
Ages 18 to 55 · Women · Updated Sep 9, 2026 · NCT07310420

Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer

RecruitingPhase 3
  • AdventHealth, Altamonte Springs · 9 mi away
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT06982521

Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

RecruitingPhase 3
  • AdventHealth Orlando, Orlando
  • Orlando Health Cancer Institute, Orlando
  • AdventHealth Altamonte, Altamonte Springs · 9 mi away
  • and 1 more
Ages 18 to 60 · Women · Updated Sep 2, 2026 · NCT05879926

Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer.

RecruitingPhase 3
  • Advent Health - Orlando, Orlando
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT06072612

De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

RecruitingPhase 3
  • AdventHealth Orlando, Orlando
  • Orlando Health Cancer Institute, Orlando
  • AdventHealth Altamonte, Altamonte Springs · 9 mi away
  • and 1 more
Ages 50 to 70 · All sexes · Updated Apr 23, 2026 · NCT04852887

A Study of DB-1310 in Advanced/Metastatic Solid Tumors

RecruitingPhase 1/2
  • Sarah Cannon Research Institute at Florida Cancer Specialists, Orlando
Ages 18 and older · All sexes · Updated Apr 6, 2026 · NCT05785741

Open-Label Study to Evaluate the Safety, Tolerability, PK, and Efficacy of INX-315 in Patients With Advanced Cancer

RecruitingPhase 1/2
  • Florida Cancer Specialists, Orlando
Ages 18 and older · All sexes · Updated Apr 1, 2026 · NCT05735080

EXActDNA-003 / NSABP B-64: Study of Molecular Residual Disease Detection in Breast Cancer (MRD)

RecruitingObservational study
  • AdventHealth East Altamonte Oncology and Hematology, Altamonte Springs · 9 mi away
Ages 18 and older · All sexes · Updated Jan 20, 2026 · NCT06401421

Building on Trust: Navigating Preventive Lung, Breast, and Prostate Cancer Screenings at Community Resource Spots

RecruitingObservational studyHealthy volunteers welcome
  • Adventhealth, Orlando
Ages 18 and older · All sexes · Updated Nov 17, 2025 · NCT07231159

UCF MammoChat: Image Repository

RecruitingObservational studyHealthy volunteers welcome
  • University of Central Florida, Orlando
Ages 18 and older · All sexes · Updated Oct 9, 2025 · NCT07214883

A Phase 1 Study of XL309 (ISM3091) Alone and in Combination in Participants With Advanced Solid Tumors

RecruitingPhase 1
  • Exelixis Clinical Site #8, Orlando
Ages 18 and older · All sexes · Updated Sep 5, 2025 · NCT05932862

About Breast Cancer

Breast cancer is a cancer that starts in the breast tissue, when cells change and grow out of control. These extra cells can form a mass called a tumor.

More about Breast Cancer on MedlinePlus

Breast Cancer trials in other cities

Other studies in Orlando

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.