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Non-Small Cell Lung Cancer clinical trials in Orlando, FL
44 studies for Non-Small Cell Lung Cancer are looking for participants at sites in and around Orlando (within about 30 miles). Open a study to see who can join and how to contact the study team.
Neladalkib (NVL-655) for TKI-naive Patients With Advanced ALK-Positive NSCLC
RecruitingPhase 3
- AdventHealth Cancer Institute, Orlando
A Study to Evaluate the Efficacy of Pumitamig Versus Pembrolizumab in Participants With Previously Untreated Advanced Non-Small Cell Lung Cancer and PD-L1 ≥ 50%. (ROSETTA Lung-202)
RecruitingPhase 3
- Clermont Oncology Center, Clermont · 24 mi away
A Study of Amivantamab in Participants With Advanced or Metastatic Solid Tumors Including Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer
RecruitingPhase 2
- AdventHealth, Orlando
Symbiotic-Lung-20: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Different Anticancer Agents in Advanced Cancers
RecruitingPhase 1/2
- Orlando Health Ambulatory Care Center, Orlando
- Orlando Health Cancer Institute, Orlando
- Orlando Health Orlando Regional Medical Center, Orlando
Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer
RecruitingPhase 3
- Florida Cancer Specialists, Orlando
- Orlando Health Ambulatory Care Center, Orlando
- Orlando Health Cancer Institute, Orlando
- and 4 more
A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
RecruitingPhase 2
- AdventHealth Orlando, Orlando
- Orlando Health Cancer Institute, Orlando
A Study of JNJ-90301900 in Combination With Chemoradiation Followed by Consolidation Immunotherapy for Non-Small Cell Lung Cancer (NSCLC)
RecruitingPhase 2
- Orlando Health Cancer Institute, Orlando
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
RecruitingPhase 2
- AdventHealth Medical Group Oncology Research at Celebration, Kissimmee · 16 mi away
Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations
RecruitingPhase 3
- Research Site, Orlando
- Research Site, Clermont · 24 mi away
Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and Other Investigational Agents for Lung Cancer
RecruitingPhase 2/3
- Clermont Oncology Center, Clermont · 24 mi away
Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors
RecruitingPhase 1
- Sara Cannon Research Institute Lake Nona, Orlando
Personalized Cancer Vaccine (PCV) Strategy in Patients With Solid Tumors and Molecular Residual Disease
RecruitingPhase 1
- AdventHealth, Orlando
Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients With High PD-L1
RecruitingPhase 3
- Clinical Study Site, Orlando
A Study of [225Ac]Ac-AKY-1189 in Patients With Solid Tumors
RecruitingPhase 1
- Advent Health Medical Group Radiation Oncology at Central Florida, Orlando
Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7
RecruitingPhase 2/3
- AdventHealth Orlando, Orlando
- Local Institution - 007-896-A, Celebration · 17 mi away
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
RecruitingPhase 1/2
- Advent Health, Orlando
A Study of PRMT5 Inhibitor BAY 3713372 in Participants With MTAP-deleted Solid Tumors
RecruitingPhase 1/2
- Sarah Cannon Research Institute at Florida Cancer Specialists- Lake Nona, Orlando
A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer
RecruitingPhase 3
- Orlando Health Cancer Institute, Orlando
Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion
RecruitingPhase 1
- Sarah Cannon Research Institute at Florida Cancer Specialists, Orlando
A Study to Evaluate KIN-2787 in Participants With BRAF and/or NRAS Mutation Positive Solid Tumors
RecruitingPhase 1
- Sarah Cannon Research Institute - Florida Cancer Specialists, Orlando
MOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors
RecruitingPhase 1
- Florida Cancer Specialists - Lake Nona - Sarah Cannon Research Institute, Orlando
SMP-3124LP in Adults With Advanced Solid Tumors
RecruitingPhase 1/2
- Advent Health, Celebration · 17 mi away
A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors
RecruitingPhase 1/2
- AdventHealth Celebration, Celebration · 17 mi away
A Study of BH-30643 in Subjects With Locally Advanced or Metastatic NSCLC Harboring EGFR and/or HER2 Mutations
RecruitingPhase 1/2
- Sarah Cancer Research Institution - Florida Cancer Specialist, Orlando
Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
RecruitingPhase 1
- Exelixis Clinical Site #48, Celebration · 17 mi away
Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist)
RecruitingPhase 1/2
- Clermont Oncology Center, Clermont · 24 mi away
A Phase 1 of CTX-8371 in Patients With Advanced Malignancies
RecruitingPhase 1
- Florida Cancer Specialists - Lake Nona, Orlando
A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors
RecruitingPhase 1
- Florida Cancer Specialists, Orlando
- Sarah Cannon Research Institute at Florida Cancer Specialists, Orlando
Safety and Efficacy of OBX-115 in Advanced Solid Tumors
RecruitingPhase 1/2
- Orlando Health Cancer Institute (Melanoma/NSCLC), Orlando
A Study of Sigvotatug Vedotin in Advanced Solid Tumors
RecruitingPhase 1
- Florida Cancer Specialists, Orlando
A Study of LY4175408 in Participants With Advanced Cancer
RecruitingPhase 1
- Florida Cancer Specialists - Lake Nona - Sarah Cannon Research Institute, Orlando
Study of XB010 in Subjects With Solid Tumors
RecruitingPhase 1
- Sarah Cannon Research Institute at Florida Cancer Specialists, Orlando
A Study to Investigate the Efficacy and Safety of an Infusion of IOV-4001 in Adult Participants With Unresectable or Metastatic Melanoma or Stage III or IV Non-small-cell Lung Cancer
RecruitingPhase 1/2
- Orlando Health Cancer Institute, Orlando
A Study to Learn About Study Medicine ALTA3263 in Adults With Advanced Solid Tumors With KRAS Mutations
RecruitingPhase 1
- Research Site, Orlando
KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors
RecruitingPhase 1
- AdventHealth Celebration, Celebration · 17 mi away
Efficacy & Safety of Olvimulogene Nanivacirepvec & Platinum-doublet + Physician's Choice of Immune Checkpoint Inhibitor Compared to Docetaxel in NSCL Cancer
RecruitingPhase 2
- Clermont Oncology Center, Clermont · 24 mi away
Phase 3 Study of Taletrectinib vs Placebo as an Adjuvant Therapy in ROS1 Positive NSCLC (TRUST-IV)
RecruitingPhase 3
- Advent Health, Orlando
A Study of DB-1310 in Advanced/Metastatic Solid Tumors
RecruitingPhase 1/2
- Sarah Cannon Research Institute at Florida Cancer Specialists, Orlando
A Phase 1 Study of CPO301 in Adult Patients With Advanced or Metastatic Solid Tumors
RecruitingPhase 1
- AdventHealth Cancer Institute, Celebration · 17 mi away
Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors
RecruitingPhase 1/2
- Florida Cancer Specialists-Lake Nona, Orlando
GEMINI-NSCLC: NSCLC Biomarker Study
RecruitingObservational study
- Clermont Oncology Center, Clermont · 24 mi away
A Study to Evaluate the Safety, Pharmacokinetics and Efficacy of TJ101 in Patients With Advanced/Metastatic Solid Tumors
RecruitingPhase 1
- Florida Cancer Specialists & Research Institute, Orlando
A Study of DR-0202 in Patients With Locally Advanced or Metastatic, Relapsed or Refractory Carcinomas
RecruitingPhase 1
- Dren Investigational Site, Orlando
A Phase 1/2a Study of DB-1311/BNT324 in Advanced/Metastatic Solid Tumors
RecruitingPhase 1/2
- Research Site 137, Orlando
- Research Site 118, Celebration · 17 mi away
Non-Small Cell Lung Cancer trials in other cities
- Houston, TX145 studies
- New York City, NY120 studies
- Arlington, VA104 studies
- Nashville, TN96 studies
- Boston, MA89 studies
- Los Angeles, CA87 studies
- St. Louis, MO71 studies
- Chicago, IL61 studies
- Baltimore, MD60 studies
- San Antonio, TX59 studies
- Columbus, OH55 studies
- Washington, DC54 studies
Other studies in Orlando
- Metastatic Cancer29 studies
- Obesity29 studies
- Cancer (all types)25 studies
- Alzheimer's Disease25 studies
- Overweight25 studies
- Type 2 Diabetes24 studies
- Breast Cancer23 studies
- Ulcerative Colitis23 studies
- Ovarian Cancer22 studies
- Lung Cancer21 studies
- Colorectal Cancer19 studies
- Major Depressive Disorder19 studies
From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.