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Major Depressive Disorder clinical trials in Birmingham, AL

9 studies for Major Depressive Disorder are looking for participants at sites in and around Birmingham (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder

RecruitingPhase 3
  • University of Alabama at Birmingham - School of Medicine, Birmingham
Ages 18 to 75 · All sexes · Updated Oct 1, 2026 · NCT07775300

A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive Disorder

RecruitingPhase 3
  • University of Alabama at Birmingham, Birmingham
Ages 12 to 17 · All sexes · Updated Sep 25, 2026 · NCT07227454

A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder

RecruitingPhase 3
  • UAB Psychiatry and Behavioral Neurology, Birmingham
Ages 18 to 85 · All sexes · Updated Sep 25, 2026 · NCT06793397

Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

Recruiting
  • University of Alabama at Birmingham - Dept. of Psychiatry, Birmingham
Ages 22 to 70 · All sexes · Updated Aug 28, 2026 · NCT06423430

Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression

RecruitingPhase 3
  • Birmingham VA Medical Center, Birmingham, AL, Birmingham
Ages 18 to 75 · All sexes · Updated Aug 14, 2026 · NCT07226232

Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder

RecruitingPhase 2
  • University of Alabama at Birmingham, Birmingham
Ages 18 to 64 · All sexes · Updated Aug 3, 2026 · NCT06547489

Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome in Adolescents

RecruitingHealthy volunteers welcome
  • University of Alabama at Birmingham, Birmingham
Ages 10 to 24 · All sexes · Updated Jul 13, 2026 · NCT05437588

MicroRNA Correlates of Childhood Maltreatment and Suicidality

RecruitingObservational studyHealthy volunteers welcome
  • University of Alabama at Birmingham, Birmingham
Ages 18 to 60 · All sexes · Updated Mar 30, 2026 · NCT04923685

Study of ABX-002 for the Adjunctive Treatment of Major Depressive Disorder (AMPLIFY)

RecruitingPhase 2
  • Autobahn Site #131, Birmingham
Ages 18 to 65 · All sexes · Updated Jan 20, 2026 · NCT06633016

Major Depressive Disorder trials in other cities

Other studies in Birmingham

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.