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Mild Cognitive Impairment clinical trials in Boston, MA

21 studies for Mild Cognitive Impairment are looking for participants at sites in and around Boston (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

A Study of Donanemab (LY3002813) in Participants With Early Cognitive Decline (TRAILBLAZER-ALZ 7)

RecruitingPhase 2
  • Massachusetts General Hospital - Charlestown, Charlestown · 1 mi away
Ages 55 to 85 · All sexes · Updated Sep 22, 2026 · NCT07589595

Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies

RecruitingPhase 3
  • Adams Clinical Boston, Boston
Ages 50 to 90 · All sexes · Updated Sep 21, 2026 · NCT07177352

Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY

RecruitingObservational study
  • Massachusetts General Hospital, Boston
  • Boston Medical Center, Boston
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT04916210

Sleep and Circadian Rhythm Biomarkers of Postoperative Delirium

RecruitingObservational study
  • Massachusetts General Hospital, Boston
Ages 70 and older · All sexes · Updated Sep 14, 2026 · NCT06052397

Contributions of mTBI to Neurodegeneration Due to Chronic Traumatic Encephalopathy (CTE) and Alzheimer's Disease (AD)

RecruitingObservational studyHealthy volunteers welcome
  • VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston
Ages 30 to 90 · All sexes · Updated Sep 1, 2026 · NCT04124029

Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

RecruitingPhase 4Healthy volunteers welcome
  • VA Boston Healthcare System, Boston
Ages 75 and older · All sexes · Updated Sep 1, 2026 · NCT04262206

A First-In-Human Study of LY3954068 in Participants With Early Symptomatic Alzheimer's Disease

RecruitingPhase 1
  • Massachusetts General Hospital (MGH), Charlestown · 1 mi away
Ages 50 to 85 · All sexes · Updated Aug 24, 2026 · NCT06297590

Use of a Mobile Brain-Body Imaging Approach to Evaluate the Effects of Rhythmic Auditory Stimulation on Gait and Brain Function in Alzheimer's Disease

RecruitingHealthy volunteers welcome
  • Boston University Neuromotor Recovery Laboratory, Boston
Ages 50 to 90 · All sexes · Updated Aug 13, 2026 · NCT07659964

Individual Closed-Loop Neuromodulation Therapy for Alzheimer's Disease

RecruitingHealthy volunteers welcome
  • Massachusetts General Hospital, Charlestown · 1 mi away
Ages 50 to 80 · All sexes · Updated Jul 14, 2026 · NCT05904132

Healthy Aging as Black Adults, In It Together: a Comparative Effectiveness Study of Chronic Pain and Cognitive Decline

Recruiting
  • Massachusetts General Hospital, Boston
Ages 50 and older · All sexes · Updated Jul 7, 2026 · NCT06246929

Biomarker-based Trial of NPC-1 for Alzheimer's Pathology

RecruitingPhase 2
  • Massachusetts General Hospital, Boston
Ages 55 and older · All sexes · Updated Jun 8, 2026 · NCT07236190

Transcranial Magnetic Stimulation Treatment for Alzheimer's Disease

RecruitingEarly phase 1Healthy volunteers welcome
  • Massachusetts General Hospital, Boston
Ages 40 to 99 · All sexes · Updated May 6, 2026 · NCT06538311

Digital Accessible Remote Olfactory Mediated Health Assessments for Preclinical AD

RecruitingObservational studyHealthy volunteers welcome
  • Massachusetts General Hospital, Boston
Ages 18 to 100 · All sexes · Updated Mar 6, 2026 · NCT05881239

TMS for Cognitive Decline in Aging and Preclinical AD

RecruitingHealthy volunteers welcome
  • Massachusetts General Hospital, Boston
Ages 40 to 99 · All sexes · Updated Feb 20, 2026 · NCT06956300

Assessment of Foralumab Safety and Modulation of Microglial Activation in Alzheimer's Disease

RecruitingPhase 2
  • Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Boston
Ages 60 to 85 · All sexes · Updated Feb 12, 2026 · NCT06489548

Treating Insomnia in Mild Cognitive Impairment

Recruiting
  • Beth Israel Deaconess Medical Center, Boston
Ages 60 and older · All sexes · Updated Oct 24, 2025 · NCT06687161

LIFT: Life Improvement Trial

RecruitingPhase 2
  • Brigham and Women's Hospital, Boston
Ages 18 to 70 · All sexes · Updated Oct 22, 2025 · NCT06366724

Leveraging Social Networks to Improve Sleep and Mindfulness Among Older Adults in Residential Housing Facilities

RecruitingHealthy volunteers welcome
  • Brigham and Women's Hospital, Boston
Ages 55 and older · All sexes · Updated May 25, 2025 · NCT06989619

Cognitive Dysfunction and Inflammation in Depression: Experimental Inhibition Via Infliximab

RecruitingPhase 2
  • Massachusetts General Hospital, Boston
Ages 25 to 50 · All sexes · Updated May 7, 2025 · NCT06136546

Cognitive Dysfunction in Chronic and Persistent Immune Thrombocytopenia

RecruitingObservational study
  • Massachusetts General Hospital, Boston
Ages 18 and older · All sexes · Updated Feb 10, 2025 · NCT06817395

Mindfulness for Cognition in Early-stage Alzheimer's Disease

RecruitingHealthy volunteers welcome
  • VA Boston Healthcare System - Jamaica Plain Campus, Boston
Ages 50 to 100 · All sexes · Updated Jan 27, 2025 · NCT06792877

About Mild Cognitive Impairment

In mild cognitive impairment (MCI), you have more memory and thinking problems than others your age, but they don't interfere with your everyday life.

More about Mild Cognitive Impairment on MedlinePlus

Mild Cognitive Impairment trials in other cities

Other studies in Boston

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.