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Major Depressive Disorder clinical trials in New York City, NY
36 studies for Major Depressive Disorder are looking for participants at sites in and around New York City (within about 30 miles). Open a study to see who can join and how to contact the study team.
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A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
RecruitingPhase 3
- Adams Clinical Harlem, New York
- New York State Psychiatric Institute, New York
A Study of Brenipatide in Adult Participants With Major Depressive Disorder
RecruitingPhase 3
- Adams Clinical Harlem, New York
A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder
RecruitingPhase 3
- Fieve Clinical Research Inc, New York
- Adams Clinical Harlem, New York
- Manhattan Behavioral Medicine, New York
Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder
RecruitingPhase 3
- Manhattan Behavioral Medicine, New York
Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms
RecruitingPhase 3
- Fieve Clinical Research Inc, New York
A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)
RecruitingPhase 2
- Ima Clinical Research - Nyc Midtown, New York
Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive Disorder
RecruitingPhase 3
- Vanda Investigational Site, New York
- Vanda Investigational Site, New York
DBS for TRD With the Medtronic Percept PC
Recruiting
- Icahn School of Medicine at Mount Sinai, Mount Sinai West, New York
Pattern Separation in Major Depressive Disorder
RecruitingPhase 1
- New York State Psychiatric Institute (NYSPI), New York
A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)
RecruitingPhase 2
- Seaport Investigator Site, New York
A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3)
RecruitingPhase 3
- Fieve Clinical Research, Inc., New York
- IMA Clinical Research, New York
A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression
RecruitingPhase 2
- Draig Clinical Site, New York
- Draig Clinical Site, New York
Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
Recruiting
- Mount Sinai Hospital, New York
A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression
RecruitingPhase 2
- Draig Clinical Site, New York
NBI-1065845-MDD3025: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
RecruitingPhase 3
- Neurocrine Clinical Site, New York
NBI-1065845-MDD3026: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
RecruitingPhase 3
- Neurocrine Clinical Site, New York
A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder
RecruitingPhase 2
- IMA Clinical Research - NYC Midtown, New York
- IMA Clinical Research - NYC Uptown, New York
Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol
RecruitingPhase 3
- Clinical Research Site, New York
- Clinical Research Site, New York
Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
RecruitingPhase 3
- Neurocrine Clinical Site, New York
- Neurocrine Clinical Site, New York
Feasibility of Home-Based Intermittent 60Hz Light Therapy for Major Depressive Disorder (MDD)
Recruiting
- NYU Langone Health, New York
A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder
RecruitingPhase 2
- Ima Clinical Research - Manhattan /ID# 278212, New York
- Manhattan Behavioral Medicine /ID# 277910, New York
tDCS: Sleep to Mood in Depression (S2M-D)
Recruiting
- NYU Langone Health, New York
Triage Survey for Psychiatry Research Eligibility
RecruitingObservational study
- Adams Clinical, Harlem, New York
A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)
RecruitingPhase 2
- The Medical Research Network, LLC, New York
Aβ Dynamics in LLMD
RecruitingPhase 4
- NYU Langone Health, New York
Maintenance rTMS for Depression (Maitr-De)
Recruiting
- Weill Cornell Medicine, New York
Neutralizing Interleukin (IL)-6
RecruitingPhase 2Healthy volunteers welcome
- Icahn School of Medicine at Mount Sinai, New York
Mindfulness-Based fMRI Neurofeedback for Depression
Recruiting
- Columbia University Irving Medical Center, New York
Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality
Recruiting
- Weill Cornell Medicine, New York
Biomarker-guided rTMS for Treatment Resistant Depression
RecruitingPhase 3
- Weill Cornell Medicine, New York
Transcranial Near Infrared Radiation and Cerebral Blood Flow in Depression - R33
Recruiting
- NYU Langone Health, New York
Invasive Decoding and Stimulation of Altered Reward Computations in Depression Patients
Recruiting
- Icahn School of Medicine at Mount Sinai, New York
Ketamine-Assisted Psychotherapy (KAP) Compared to Ketamine Alone for the Treatment of Depression
RecruitingPhase 2
- Icahn School of Medicine at Mount Sinai, New York
Neural Circuit Effects of Ketamine in Depression
RecruitingPhase 4Healthy volunteers welcome
- Icahn School of Medicine at Mount Sinai, New York
Psilocybin With Pimavanserin Compared to Psilocybin Alone for the Treatment of Major Depressive Disorder
RecruitingPhase 2
- Icahn School of Medicine at Mount Sinai, Center for Psychedelic Therapy Research, New York
A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms
RecruitingPhase 4
- Clinical Research Site, New York
Major Depressive Disorder trials in other cities
- Boston, MA31 studies
- Atlanta, GA25 studies
- Philadelphia, PA23 studies
- Orlando, FL19 studies
- Miami, FL18 studies
- Chicago, IL17 studies
- Tampa, FL17 studies
- Houston, TX16 studies
- San Diego, CA16 studies
- Little Rock, AR14 studies
- Austin, TX13 studies
- Las Vegas, NV13 studies
Other studies in New York City
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- Metastatic Cancer93 studies
- Colorectal Cancer78 studies
- Ovarian Cancer69 studies
- Lung Cancer60 studies
- Multiple Myeloma60 studies
- Pancreatic Cancer60 studies
- Endometrial Cancer52 studies
- Acute Myeloid Leukemia51 studies
From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.