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Head and Neck Cancer clinical trials in St. Louis, MO

15 studies for Head and Neck Cancer are looking for participants at sites in and around St. Louis (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC

RecruitingPhase 2/3
  • Site #0114, St Louis
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06788990

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 2
  • Washington University, School of Medicine, St Louis
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06172478

Online Perioperative Education Program on Patient Satisfaction and Clinical Outcomes for Head and Neck Surgery

Recruiting
  • Washington University School of Medicine, St Louis
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT07848841

First in Human Study of TUB-030 in Patients With Advanced Solid Tumors

RecruitingPhase 1/2
  • Washington University, St Louis
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT06657222

Building a Renewed ImaGe After Head & Neck Cancer Treatment (BRIGHT) Multi-Site RCT

Recruiting
  • Washington University in St. Louis, St Louis
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT05442957

Ovarian-Sparing Adaptive Radiotherapy in Young Adult Women

RecruitingObservational study
  • Washington University School of Medicine, St Louis
Ages 18 to 50 · Women · Updated Sep 2, 2026 · NCT06904365

IDOV-Immune for Advanced Solid Tumors

RecruitingPhase 1
  • Washington University School of Medicine, St Louis
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT06910657

First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • Washington University, St Louis
Ages 18 and older · All sexes · Updated Jul 7, 2026 · NCT05768139

Lead-212 PSV359 Therapy for Patients With Solid Tumors

RecruitingPhase 1/2
  • Saint Louis University, St Louis
Ages 18 to 90 · All sexes · Updated Jul 6, 2026 · NCT06710756

Predicting Response to Immunotherapy From Analysis of Live Tumor Biopsies (ELEPHAS-05)

RecruitingObservational study
  • Mercy Hospital - South, St Louis
  • Mercy Hospital -STL, St Louis
Ages 18 and older · All sexes · Updated Jun 29, 2026 · NCT07327489

A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements

RecruitingPhase 1/2
  • Washington University Infusion Center Pharmacy, St Louis
Ages 12 and older · All sexes · Updated May 27, 2026 · NCT03093116

A Study of Dostarlimab vs Placebo After Chemoradiation in Adult Participants With Locally Advanced Unresected Head and Neck Squamous Cell Carcinoma

RecruitingPhase 3
  • GSK Investigational Site, St Louis
Ages 18 and older · All sexes · Updated May 26, 2026 · NCT06256588

Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors

RecruitingObservational studyHealthy volunteers welcome
  • Washington University School of Medicine, St Louis
Ages 18 and older · All sexes · Updated Feb 20, 2026 · NCT04354064

Multi-Site Trial of Navigation vs Treatment as Usual to Improve Initiation of Timely Adjuvant Therapy

Recruiting
  • Washington University in St. Louis, St Louis
Ages 18 and older · All sexes · Updated Dec 11, 2025 · NCT05793151

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, St Louis
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

About Head and Neck Cancer

Head and neck cancer includes cancers of the mouth, nose, sinuses, salivary glands, throat, and lymph nodes. Read the different symptoms of each type.

More about Head and Neck Cancer on MedlinePlus

Head and Neck Cancer trials in other cities

Other studies in St. Louis

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.