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Glioblastoma clinical trials in Boston, MA

28 studies for Glioblastoma are looking for participants at sites in and around Boston (within about 30 miles). Open a study to see who can join and how to contact the study team.

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A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma

RecruitingPhase 2/3
  • Massachusetts General Hospital, Boston
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT03970447

Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII

RecruitingPhase 2
  • Massachusetts General Hospital, Boston
  • Beth Israel Deaconess Medical Center, Boston
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07326566

A Study of Repotrectinib in Pediatric and Young Adult Subjects Harboring ALK, ROS1, OR NTRK1-3 Alterations

RecruitingPhase 1/2
  • Dana Farber Cancer Institute., Boston
Up to age 25 · All sexes · Updated Sep 25, 2026 · NCT04094610

Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis

RecruitingPhase 1/2
  • Tufts Medical Center, Boston
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06047379

Anti-GD2 ADC M3554 in Advanced Solid Tumors

RecruitingPhase 1
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06641908

A Study of PRMT5 Inhibitor BAY 3713372 in Participants With MTAP-deleted Solid Tumors

RecruitingPhase 1/2
  • Massachusetts General Hospital - Neurology, Boston
  • Dana-Farber Cancer Institute - Oncology Department, Boston
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06914128

Targeted Pediatric High-Grade Glioma Therapy

RecruitingObservational study
  • Dana-Farber Cancer Institute, Boston
12 Months – 39 Years · All sexes · Updated Sep 8, 2026 · NCT05839379

Serial MRI Scans During Radiation Therapy

Recruiting
  • Brigham and Women Hospital, Boston
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT04188535

Study of Olutasidenib and Temozolomide in HGG

RecruitingPhase 2
  • Susan Chi, Boston
Ages 12 to 39 · All sexes · Updated Sep 1, 2026 · NCT06161974

SIGMA (Safusidenib in IDH1 Mutant Glioma Maintenance)

RecruitingPhase 3
  • Massachusetts General Hospital, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Aug 28, 2026 · NCT05303519

INdividualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT)

RecruitingPhase 2
  • Massachusetts General Hospital, Boston
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT02977780

Adjuvant Temozolomide ± 5-Aminolevulinic Acid + Low Intensity Diffuse Ultrasound Sonodynamic Therapy System for Newly Diagnosed Glioblastoma

RecruitingPhase 2
  • Dana Farber Cancer Institute, Boston
Ages 18 to 80 · All sexes · Updated Jul 17, 2026 · NCT07225621

CARv3-TEAM-E T Cells in Glioblastoma

RecruitingPhase 1
  • Massachusetts General Hospital Cancer Center, Boston
Ages 18 and older · All sexes · Updated Jul 14, 2026 · NCT05660369

DOC1021 Dendritic Cell Immunotherapy for Treatment of Newly Diagnosed Adult Glioblastoma (GBM)

RecruitingPhase 2
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Jul 1, 2026 · NCT06805305

Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

RecruitingEarly phase 1Healthy volunteers welcome
  • Dana-Farber Cancer Institute, Boston
Ages 1 to 21 · All sexes · Updated Jun 29, 2026 · NCT06333899

Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

RecruitingPhase 2
  • Dana-Farber Cancer Institute, Boston
12 Months – 39 Years · All sexes · Updated May 29, 2026 · NCT05843253

G-CSF After Chemo-radiation in Patients With Glioblastoma

RecruitingPhase 2
  • Massachusetts General Hospital, Boston
Ages 18 and older · All sexes · Updated May 5, 2026 · NCT06649851

Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss

RecruitingPhase 1/2
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Apr 13, 2026 · NCT06810544

CUE-102 in Recurrent Glioblastoma

RecruitingPhase 1
  • Brigham and Women's Hospital, Boston
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Mar 5, 2026 · NCT06917885

A Study to Evaluate TROP2 ADC LCB84 Single Agent and in Combination With an Anti-PD-1 Ab in Advanced Solid Tumors

RecruitingPhase 1/2
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Sep 24, 2025 · NCT05941507

Enhanced Local Intensified Radiation Therapy in Elderly Glioblastoma: A Phase 2 Hybrid Randomized Trial

RecruitingPhase 2
  • Brigham and Women's Hospital, Boston
Ages 65 and older · All sexes · Updated Sep 18, 2025 · NCT06835803

A Surgical Window of Opportunity Clinical Trial of Troriluzole in Recurrent IDH Wild-Type Glioblastoma

RecruitingEarly phase 1
  • Brigham and Women's Hospital, Boston
  • Dana-Farber Cancer Institute, Boston
  • Massachusetts General Hospital Cancer Center, Boston
Ages 18 and older · All sexes · Updated Sep 11, 2025 · NCT06552260

Implantable Microdevice In Primary Brain Tumors

RecruitingEarly phase 1
  • Brigham and Women's Hospital, Boston
Ages 18 and older · All sexes · Updated Jul 23, 2025 · NCT04135807

The RECSUR-study: Resection Versus Best Oncological Treatment for Recurrent Glioblastoma (ENCRAM 2302)

RecruitingObservational study
  • Massachusetts General Hospital, Boston
Ages 18 to 90 · All sexes · Updated Feb 28, 2024 · NCT06283927

The RECMAP-study: Resection With or Without Intraoperative Mapping for Recurrent Glioblastoma

RecruitingObservational study
  • Massachusetts General Hospital, Boston
Up to age 90 · All sexes · Updated Feb 22, 2024 · NCT06273176

The SUPRAMAX Study: Supramaximal Resection Versus Maximal Resection for High-Grade Glioma Patients (ENCRAM 2201)

RecruitingObservational study
  • Massachusetts General Hospital, Boston
Ages 18 to 90 · All sexes · Updated Feb 22, 2024 · NCT06118723

The PALSUR-study: Palliative Care Versus Surgery in High-grade Glioma Patients (ENCRAM 2203)

RecruitingObservational study
  • Massachusetts General Hospital, Boston
Ages 18 to 90 · All sexes · Updated Nov 27, 2023 · NCT06146738

The RESBIOP-study: Resection Versus Biopsy in High-grade Glioma Patients (ENCRAM 2202)

RecruitingObservational study
  • Massachusetts General Hospital, Boston
Ages 18 to 90 · All sexes · Updated Nov 27, 2023 · NCT06146725

Glioblastoma trials in other cities

Other studies in Boston

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.