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Melanoma clinical trials in Philadelphia, PA
23 studies for Melanoma are looking for participants at sites in and around Philadelphia (within about 30 miles). Open a study to see who can join and how to contact the study team.
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Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
RecruitingObservational studyHealthy volunteers welcome
- Reading Hospital McGlinn Cancer Institute at Phoenixville, Phoenixville · 22 mi away
DESTINY-PANTUMOUR04
RecruitingObservational study
- Research Site, Philadelphia
BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study
RecruitingPhase 2
- Thomas Jefferson University Hospital, Philadelphia
A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)
RecruitingPhase 3
- Fox Chase Cancer Center, Philadelphia
A Study on How to Safely Guide Surgery for Melanoma and Similar Skin Tumors in Children Using Pathology and Genetic Information
RecruitingPhase 2
- Children's Hospital of Philadelphia, Philadelphia
- Alfred I duPont Hospital for Children, Wilmington · 25 mi away
Comparing the Effectiveness of Less Invasive Procedures With the Current Standard of Care for the Treatment of Older Adults With Early-Stage Melanoma
RecruitingPhase 3
- Thomas Jefferson University Hospital, Philadelphia
- Fox Chase Cancer Center, Philadelphia
- Asplundh Cancer Pavilion, Willow Grove · 13 mi away
- and 3 more
BI-1808 as a Single Agent and With Pembrolizumab (KEYTRUDA® ) in Treatment of Advanced Malignancies(Keynote-D20)
RecruitingPhase 1/2
- University of Pennsylvania, Philadelphia
ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation
RecruitingObservational study
- University of Pennsylvania, Philadelphia
Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors
RecruitingPhase 1/2
- Children's Hospital of Philadelphia, Philadelphia
Project: Every Child for Younger Patients With Cancer
RecruitingObservational study
- Drexel University School of Medicine, Philadelphia
- Children's Hospital of Philadelphia, Philadelphia
- Saint Christopher's Hospital for Children, Philadelphia
- and 1 more
Tebentafusp-tebn With LDT in Metastatic UM
RecruitingPhase 1/2
- Thomas Jefferson University, Philadelphia
MC1R-targeted Alpha-particle Monotherapy and Combination Therapy Trial With Nivolumab in Adults With Advanced Melanoma
RecruitingPhase 1/2
- Fox Chase Cancer Center, Philadelphia
Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions
RecruitingPhase 1/2
- Sidney Kimmel Cancer Center at Thomas Jefferson University, Philadelphia
Study of CBL0137 in Combination With Ipilimumab and Nivolumab Therapy in Melanoma
RecruitingEarly phase 1
- Fox Chase Cancer Center, Philadelphia
ACTengine® IMA203/IMA203CD8 as Monotherapy or in Combination With Nivolumab in Recurrent and/or Refractory Solid Tumors
RecruitingPhase 1/2
- University of Pennsylvania, Perelamn Center for Advanced Medicine, Philadelphia
- Thomas Jefferson University, Honickman Center, Philadelphia
- Fox Chase Cancer Center, Philadelphia
Neoadjuvant Darovasertib in Primary Uveal Melanoma
RecruitingPhase 3
- Jefferson Health Honickman Center, Philadelphia
A Trial of LNS8801 With or Without Pembrolizumab in Patients With Refractory Melanoma
RecruitingPhase 2/3
- UPenn, Philadelphia
A Randomized, Phase 2/3 Study to Investigate the Efficacy and Safety of RP2 in Combination With Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients With Metastatic Uveal Melanoma
RecruitingPhase 2/3
- Thomas Jefferson University, Philadelphia
Tebentafusp Regimen Versus Investigator's Choice in Previously Treated Advanced Melanoma (TEBE-AM)
RecruitingPhase 3
- Thomas Jefferson University Medical Oncology Clinic, Philadelphia
Efficacy of Daromun Neoadjuvant Intratumoral Treatment in Clinical Stage IIIB/C/D Melanoma Patients
RecruitingPhase 3
- Fox Chase Cancer Center 333 Cottman Avenue, Philadelphia
SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
RecruitingObservational study
- Massive Bio SYNERGY-AI site, Philadelphia
Excision of Lymph Node Trial (EXCILYNT) (Mel69)
Recruiting
- University of Pennsylvania, Philadelphia
Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma
Recruiting
- Fox Chase Cancer Center, Philadelphia
About Melanoma
Melanoma is the most serious type of skin cancer. Most have a black or black-blue area. Learn the 'ABCDE' of what to watch for and treatment options.
More about Melanoma on MedlinePlus
Melanoma trials in other cities
- Houston, TX59 studies
- New York City, NY38 studies
- Los Angeles, CA34 studies
- Nashville, TN33 studies
- Pittsburgh, PA31 studies
- Boston, MA26 studies
- San Francisco, CA22 studies
- Atlanta, GA21 studies
- Durham, NC21 studies
- St. Louis, MO21 studies
- Columbus, OH21 studies
- Salt Lake City, UT21 studies
Other studies in Philadelphia
- Cancer (all types)59 studies
- Breast Cancer56 studies
- Non-Small Cell Lung Cancer51 studies
- Metastatic Cancer46 studies
- Colorectal Cancer44 studies
- Ovarian Cancer44 studies
- Prostate Cancer44 studies
- Lung Cancer36 studies
- Acute Myeloid Leukemia34 studies
- Heart Failure31 studies
- Endometrial Cancer28 studies
- Depression26 studies
From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.