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Amyotrophic Lateral Sclerosis clinical trials recruiting in the U.S.
71 studies for Amyotrophic Lateral Sclerosis are recruiting participants at sites across the United States.
ALS stands for Amyotrophic Lateral Sclerosis, also called Lou Gehrig's disease. ALS affects the nervous system, causing muscle problems. Find out how.
Cities with the most studies
- Boston, MA19 studies
- Philadelphia, PA14 studies
- Jacksonville, FL13 studies
- Baltimore, MD13 studies
- New York City, NY11 studies
- Chicago, IL10 studies
- San Diego, CA10 studies
- San Francisco, CA10 studies
- St. Louis, MO9 studies
- Phoenix, AZ8 studies
- Dallas, TX8 studies
- Atlanta, GA8 studies
- Washington, DC7 studies
- Seattle, WA7 studies
- Durham, NC7 studies
- Ann Arbor, MI7 studies
- Miami, FL7 studies
- Houston, TX7 studies
- Minneapolis, MN6 studies
- Los Angeles, CA5 studies
- Birmingham, AL5 studies
- Mountain View, CA5 studies
- Richmond, VA4 studies
- Detroit, MI4 studies
- Aurora, CO4 studies
- Portland, OR4 studies
- Davie, FL4 studies
- Salt Lake City, UT4 studies
- Tampa, FL4 studies
- Columbus, OH4 studies
- Gainesville, FL4 studies
- Sacramento, CA3 studies
- Indianapolis, IN3 studies
- Omaha, NE3 studies
- Harrisburg, PA3 studies
- Hartford, CT3 studies
- San Antonio, TX3 studies
- Lincoln, NE3 studies
- State College, PA3 studies
- Winston-Salem, NC3 studies
By state
- Alabama5 studies
- Arizona10 studies
- California23 studies
- Colorado5 studies
- Connecticut4 studies
- District of Columbia4 studies
- Florida27 studies
- Georgia8 studies
- Illinois11 studies
- Indiana3 studies
- Kansas4 studies
- Maryland16 studies
- Massachusetts23 studies
- Michigan9 studies
- Minnesota8 studies
- Missouri12 studies
- Nebraska6 studies
- New Hampshire3 studies
- New York12 studies
- North Carolina9 studies
- Ohio6 studies
- Oregon4 studies
- Pennsylvania19 studies
- Tennessee4 studies
- Texas14 studies
- Utah6 studies
- Virginia6 studies
- Washington7 studies
Recently updated studies
MindEx: A Novel, Multifocal, Cognitive Brain-Machine Interface System
Recruiting
Ages 18 to 65 · All sexes · Updated Oct 1, 2026 · NCT05936619Acamprosate in C9orf72 Hexanucleotide Repeat Expansion Amyotrophic Lateral Sclerosis (ACALS)
RecruitingPhase 1
Ages 18 to 99 · All sexes · Updated Oct 1, 2026 · NCT07204977RAPA-501 Therapy for ALS
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT04220190Developing New Ways to Detect Respiratory Impairment Early in ALS
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07844590Using Gaze to Enable Head-neck Movements in Patients With Head Drop
Recruiting
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07836751A Study to Investigate the Safety and Pharmacodynamics of a Single Intrathecal Injection (IT) of INS1202 in Participants With Amyotrophic Lateral Sclerosis (ALS)
RecruitingPhase 1
Ages 18 to 79 · All sexes · Updated Sep 23, 2026 · NCT07290062Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS
RecruitingPhase 3
Ages 18 to 80 · All sexes · Updated Sep 22, 2026 · NCT07322003Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
RecruitingObservational study
Ages 18 to 110 · All sexes · Updated Sep 17, 2026 · NCT03225144Imaging Assessment of Swallowing and Speech Muscles in Inclusion Body Myositis
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT07823101RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses
RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Sep 15, 2026 · NCT07002034Study is to Assess the Safety and Tolerability of VTx-002 in Participants With ALS
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT07287397Controlling Amyotrophic Lateral Sclerosis Motor Neuron Excitability Study
Recruiting
Ages 18 to 80 · All sexes · Updated Sep 10, 2026 · NCT06649955Effect of Terazosin on ATP Levels in People With Amyotrophic Lateral Sclerosis
RecruitingEarly phase 1
Ages 18 to 80 · All sexes · Updated Sep 9, 2026 · NCT07224269Interfacing With NeuroTechnology to Expand Neural Throughput (INTENT)
Recruiting
Ages 18 to 80 · All sexes · Updated Sep 2, 2026 · NCT07521930Biofluid Research on Age-Related or Inherited Neurodegeneration
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 1, 2026 · NCT07798700Usnoflast Neuromuscular Investigation for Treatment Efficacy in Amyotrophic Lateral Sclerosis
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 1, 2026 · NCT07023835Studies in Amyotrophic Lateral Sclerosis (ALS) and Other Neurodegenerative Motor Neuron Disorders
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Aug 27, 2026 · NCT05474235ASSESS ALL ALS Study
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Aug 24, 2026 · NCT06578195PREVENT ALL ALS Study
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Aug 24, 2026 · NCT06581861Investigation on the Cortical Communication (CortiCom) System
Recruiting
Ages 22 to 70 · All sexes · Updated Aug 21, 2026 · NCT03567213Tongue-strengthening Exercises in People With ALS.
Recruiting
Ages 18 to 99 · All sexes · Updated Aug 12, 2026 · NCT07295990Effects of Psilocybin in Patients With Amyotrophic Lateral Sclerosis
RecruitingEarly phase 1
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT06656702Evaluating Verbal Communication in Structured Interactions: Theoretical and Clinical Implications
RecruitingHealthy volunteers welcome
Ages 18 to 90 · All sexes · Updated Aug 7, 2026 · NCT06266403Study of COYA 302 for the Treatment of ALS
RecruitingPhase 2/3
Ages 18 to 80 · All sexes · Updated Aug 6, 2026 · NCT07161999Oral Intake of Enteral Nutrition Formula Preceding Placement and Feeding Via GTube and Its Impact on Formula Intolerance in pALS
Recruiting
Ages 18 and older · All sexes · Updated Aug 4, 2026 · NCT06609213From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.