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Prostate Cancer clinical trials in Los Angeles, CA

61 studies for Prostate Cancer are looking for participants at sites in and around Los Angeles (within about 30 miles). Open a study to see who can join and how to contact the study team.

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High Cardiovascular Risk Intervention With Cardio-Oncology Consultation for Prostate Cancer Following Androgen Receptor Pathway Inhibitor (ARPI) Therapy (Heart-Safe)

RecruitingPhase 2
  • Cedars Sinai Medical Center, Los Angeles
Ages 45 and older · Men · Updated Oct 5, 2026 · NCT07223385

Study of AZD9574 as Monotherapy and in Combination With Anti-cancer Agents in Participants With Advanced Solid Malignancies

RecruitingPhase 1/2
  • Research Site, Los Angeles
Ages 18 to 130 · All sexes · Updated Oct 5, 2026 · NCT05417594

Study of AR Suppression With Carotuximab in Metastatic, Castration-Resistant Prostate Canc

RecruitingPhase 2
  • Cedars-Sinai Medical Center, Los Angeles
Ages 18 and older · Men · Updated Oct 5, 2026 · NCT05534646

A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

RecruitingPhase 1
  • UCLA Department of Medicine-Hematology/Oncology, Los Angeles
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06465069

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2
  • UCLA Jonsson Comprehensive Cancer Center, Los Angeles
  • USC Norris Comprehensive Cancer Center, Los Angeles
Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750

Testing Different Dosing Schedules of the Anti-cancer Drug, Lutetium 177Lu PSMA RLT and Its Effect on Patients With Advanced Prostate Cancer, RECIPROCAL Trial

RecruitingPhase 3
  • Cedars-Sinai Medical Center, Los Angeles
Ages 18 and older · Men · Updated Oct 2, 2026 · NCT07200830

Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

RecruitingPhase 2
  • Keck Medicine of USC Koreatown, Los Angeles
  • Los Angeles General Medical Center, Los Angeles
  • USC / Norris Comprehensive Cancer Center, Los Angeles
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT03866382

An Investigational Scan (Flotufolastat F 18 PET/CT) for Detecting Residual or Recurrent Disease in Patients Who Completed Focal Therapy for Prostate Cancer.

RecruitingPhase 2
  • UCLA / Jonsson Comprehensive Cancer Center, Los Angeles
Ages 18 to 90 · Men · Updated Sep 29, 2026 · NCT07185165

A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)

RecruitingPhase 3
  • UCLA Hematology/Oncology - Santa Monica ( Site 0044), Los Angeles
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06136650

Study of AZD0516 as Monotherapy and in Combination in Participants With Metastatic Prostate Cancer

RecruitingPhase 1/2
  • Research Site, Los Angeles
Ages 18 to 130 · Men · Updated Sep 25, 2026 · NCT07181161

This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.

RecruitingPhase 3
  • Cedars-Sinai Cancer at Cedars-Sinai Medical Center, Los Angeles
  • Ronald Reagan UCLA Medical Center - Drug Information Center, Los Angeles
  • UCLA Department of Medicine - Hematology/Oncology, Los Angeles
  • and 1 more
Ages 18 and older · Men · Updated Sep 24, 2026 · NCT07028853

A Study in Patients With Metastatic Castration-Resistant Prostate Cancer

RecruitingPhase 1
  • START Los Angeles, Los Angeles
Ages 18 and older · Men · Updated Sep 24, 2026 · NCT07719361

A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA Mutation

RecruitingPhase 3
  • Research Site, Los Angeles
Ages 18 and older · Men · Updated Sep 18, 2026 · NCT06952803

A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)

RecruitingPhase 3
  • Cedars-Sinai Medical Center ( Site 0068), Los Angeles
  • UCLA Hematology/Oncology - Santa Monica ( Site 0002), Los Angeles
Ages 18 and older · Men · Updated Sep 17, 2026 · NCT06925737

Positron Emission Tomography Using 64Cu-SAR-bisPSMA in Participants With High-risk Prostate Cancer Prior to Radical Prostatectomy

RecruitingPhase 3
  • Urology Group of Southern California, Los Angeles
  • Greater Los Angeles VA Medical Center, Los Angeles
Ages 18 and older · Men · Updated Sep 11, 2026 · NCT06056830

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

RecruitingPhase 3
  • Cedars-Sinai Medical Center, Los Angeles
Ages 18 and older · Men · Updated Sep 10, 2026 · NCT05946213

A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors

RecruitingPhase 1
  • USC/Norris Comprehensive Cancer Center, Los Angeles
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06440005

Longitudinal Advanced Prostate Cancer Cohort (LAPCC)

RecruitingObservational study
  • Los Angeles General Medical Center, Los Angeles
  • USC / Norris Comprehensive Cancer Center, Los Angeles
Ages 18 and older · Men · Updated Sep 8, 2026 · NCT06067295

MRI-Based Machine Learning Approach Versus Radiologist MRI Reading for the Detection of Prostate Cancer, The PRIMER Trial

Recruiting
  • USC / Norris Comprehensive Cancer Center, Los Angeles
Ages 20 and older · Men · Updated Sep 1, 2026 · NCT07162194

Safety, PK and Efficacy of QXL138AM in Patients With Solid Tumors and Multiple Myeloma

RecruitingPhase 1
  • University of Southern California, Los Angeles
  • Cedars-Sanai Medical Center - Samuel Oschin Comprehensive Cancer, Los Angeles
  • Cedars-Sanai Medical Center, Los Angeles
Ages 18 and older · All sexes · Updated Aug 27, 2026 · NCT06582017

Study of Oral MRT-2359 With Apalutamide in Prostate Cancer

RecruitingPhase 2
  • START Los Angeles, Los Angeles
Ages 18 and older · Men · Updated Aug 24, 2026 · NCT07745361

Prostate Cancer Postoperative Stereotactic Body Radiotherapy With Adaptive Technology for Minimizing Toxicity

RecruitingObservational study
  • University of California at Los Angeles, Los Angeles
Ages 18 and older · Men · Updated Aug 20, 2026 · NCT07077239

High Dose-Rate Brachytherapy and Stereotactic Body Radiotherapy for the Treatment of Prostate Adenocarcinoma

Recruiting
  • University of California at Los Angeles / Jonsson Comprehensive Cancer Center, Los Angeles
Ages 18 and older · Men · Updated Aug 20, 2026 · NCT04945642

Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging

RecruitingPhase 3
  • UCLA / Jonsson Comprehensive Cancer Center, Los Angeles
Ages 18 and older · Men · Updated Aug 19, 2026 · NCT04423211

FOG-001 in Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2
  • University of California, Los Angeles (UCLA), Los Angeles
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT05919264

A Study of FG-3246 in Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC)

RecruitingPhase 2
  • VA Greater Los Angeles Healthcare System, Los Angeles
  • UCLA Clark Urology Center, Los Angeles
Ages 18 and older · Men · Updated Aug 17, 2026 · NCT06842498

Study of JANX007 in Subjects With Metastatic Castration-Resistant Prostate Cancer (ENGAGER-PSMA-01)

RecruitingPhase 1
  • USC Norris Comprehensive Cancer Center, Los Angeles
  • UCLA Department of Medicine, Los Angeles
Ages 18 to 100 · Men · Updated Aug 13, 2026 · NCT05519449

NLP-Based Feedback to Improve Risk Comms and Informed Shared Decision Making

Recruiting
  • Cedars-Sinai Medical Center, Los Angeles
Ages 18 and older · Men · Updated Aug 12, 2026 · NCT05923684

WALNUTS for POWER: Polyphenols, Omega-3 Fatty Acids, Weight Loss, and EneRgy

RecruitingPhase 2
  • Cedars-Sinai Medical Center, Los Angeles
Ages 18 and older · Men · Updated Aug 10, 2026 · NCT03824652

A Study on the Effects of Exercise Therapy on Signs of Prostate Cancer

RecruitingPhase 2
  • University of California, Los Angeles (Data and Specimen Analysis Only), Los Angeles
Ages 18 and older · Men · Updated Jul 30, 2026 · NCT05751434

PSMA PET Combined With MRI for the Detection of PCa

RecruitingPhase 3Healthy volunteers welcome
  • University of California Los Angeles, Los Angeles
Ages 18 and older · Men · Updated Jul 23, 2026 · NCT07052214

99mTc-PSMA-I&S Biodistribution in Patients With Prostate Cancer

RecruitingEarly phase 1
  • UCLA / Jonsson Comprehensive Cancer Center, Los Angeles
All ages · Men · Updated Jul 17, 2026 · NCT04857502

Hormone Therapy (Apalutamide) and Image-guided Stereotactic Body Radiation Therapy for the Treatment of Patients With Prostate Cancer, HEATWAVE Trial

RecruitingPhase 2
  • UCLA / Jonsson Comprehensive Cancer Center, Los Angeles
Ages 18 and older · Men · Updated Jul 17, 2026 · NCT06067269

Testing the Safety and Effectiveness of Radiation-based Treatment (Lutetium Lu 177 Dotatate) for Metastatic Prostate Cancer That Has Neuroendocrine Cells

RecruitingPhase 2
  • Los Angeles General Medical Center, Los Angeles
  • USC / Norris Comprehensive Cancer Center, Los Angeles
Ages 18 and older · Men · Updated Jul 14, 2026 · NCT05691465

Docetaxel to Androgen Receptor Pathway Inhibitors in Patients With Metastatic Castration Sensitive Prostate Cancer and Suboptimal PSA Response

RecruitingPhase 3
  • Kaiser Permanente Los Angeles Medical Center, Los Angeles
  • Los Angeles General Medical Center, Los Angeles
  • USC / Norris Comprehensive Cancer Center, Los Angeles
  • and 2 more
Ages 18 and older · Men · Updated Jul 14, 2026 · NCT06592924

Integrating Quantitative MRI and Artificial Intelligence to Improve Prostate Cancer Classification

RecruitingObservational study
  • UCLA / Jonsson Comprehensive Cancer Center, Los Angeles
Ages 18 and older · Men · Updated Jul 7, 2026 · NCT04765150

Abiraterone, Enzalutamide, or Apalutamide in Castrate-sensitive Prostate Cancer.

RecruitingPhase 2
  • VA Greater Los Angeles Healthcare System, Los Angeles
Ages 18 and older · Men · Updated Jun 15, 2026 · NCT05422911

Image-Guided Biopsies to Identify Mechanisms of Resistance in Patients With Metastatic Castration Resistant Prostate Cancer Treated With 177Lu-PSMA Radioligand Therapy

RecruitingPhase 1
  • UCLA / Jonsson Comprehensive Cancer Center, Los Angeles
All ages · Men · Updated Jun 15, 2026 · NCT05398302

Dose Determining Study of EXS74539 (REC-4539) in Participants With Select Solid Tumors

RecruitingPhase 1
  • Start Lacn, Los Angeles
Ages 18 and older · All sexes · Updated Jun 10, 2026 · NCT07517198

Golf Recreational Exercise for Enhanced Survivorship in Prostate Cancer Survivors

Recruiting
  • Los Angeles General Medical Center, Los Angeles
  • USC / Norris Comprehensive Cancer Center, Los Angeles
Ages 55 to 85 · Men · Updated Jun 3, 2026 · NCT06500169

Active Surveillance for Cancer of the Prostate (ASCaP)

RecruitingObservational study
  • University of California Los Angeles, Los Angeles
Ages 30 to 85 · Men · Updated May 26, 2026 · NCT00949819

Focal Radiation Therapy (HDR-Brachytherapy) for the Treatment of Prostate Cancer

Recruiting
  • UCLA / Jonsson Comprehensive Cancer Center, Los Angeles
Ages 40 and older · Men · Updated May 22, 2026 · NCT07468903

HIFU for Focal Ablation of Prostate Tissue: An Observational Study

RecruitingObservational study
  • University of California, Los Angeles, Los Angeles
Ages 40 to 85 · Men · Updated Apr 16, 2026 · NCT03620786

Green Tea and Quercetin in Combination With Docetaxel Chemotherapy in Castration-resistant Prostate Cancer Patients

RecruitingPhase 1/2
  • Charles R. Drew University of Medicine and Science, Los Angeles
Ages 18 and older · Men · Updated Apr 15, 2026 · NCT06615752

Mechanisms of Resistance to PSMA Radioligand Therapy

RecruitingObservational study
  • University of California, Los Angeles, Los Angeles
Ages 18 and older · All sexes · Updated Mar 18, 2026 · NCT05435495

Access to Genetic Testing in Underserved Patients With Cancer

RecruitingHealthy volunteers welcome
  • USC / Norris Comprehensive Cancer Center, Los Angeles
Ages 18 and older · All sexes · Updated Mar 18, 2026 · NCT06422455

Re-treatment With 177Lu-PSMA-617 for the Treatment of Metastatic Castration-Resistant Prostate Cancer, RE-LuPSMA Trial

RecruitingPhase 2
  • UCLA / Jonsson Comprehensive Cancer Center, Los Angeles
All ages · Men · Updated Mar 13, 2026 · NCT06288113

Intensive Cholesterol-Lowering and CD8+ T Cells in Prostate Cancer

RecruitingPhase 2
  • Cedars-Sinai Medical Center, Los Angeles
Ages 18 and older · Men · Updated Mar 11, 2026 · NCT06437574

Comparing a New PSMA Imaging Agent to MRI for Detecting Prostate Cancer, BEACON Trial

RecruitingEarly phase 1
  • UCLA / Jonsson Comprehensive Cancer Center, Los Angeles
Ages 18 to 90 · Men · Updated Mar 10, 2026 · NCT07164027

Phase 2 Randomized Trial of Flexible Dosing Schedule of 177Lu-PSMA-617 for the Treatment of Metastatic Castration-Resistant Prostate Cancer (FLEX-MRT)

RecruitingPhase 2
  • UCLA / Jonsson Comprehensive Cancer Center, Los Angeles
Ages 18 and older · Men · Updated Mar 10, 2026 · NCT06216249

A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

RecruitingPhase 1
  • USC - Norris Comprehensive Cancer Center, Los Angeles
Ages 18 and older · All sexes · Updated Feb 13, 2026 · NCT06778863

Image-Guidance and Online Adaptation With Stereotactic Body Radiation Therapy for the Treatment of Localized Prostate Cancer, MANTICORE Trial

Recruiting
  • UCLA / Jonsson Comprehensive Cancer Center, Los Angeles
Ages 18 and older · Men · Updated Feb 5, 2026 · NCT07276438

Vascular Optimized Radiotherapy Tuned to Critical Structures for Erectile Function Using High-Precision X-Ray Treatment

RecruitingPhase 3
  • University of California at Los Angeles, Los Angeles
Ages 18 and older · Men · Updated Dec 19, 2025 · NCT07293585

A Study of MT-4561 in Patients With Various Advanced Solid Tumors

RecruitingPhase 1/2
  • University of Southern California, Los Angeles
Ages 18 and older · All sexes · Updated Dec 11, 2025 · NCT06943521

RCT of NLP-Based Feedback for Improving SDM in Men With Localized Prostate Cancer

Recruiting
  • Cedars Sinai Medical Center, Los Angeles
Ages 18 and older · Men · Updated Dec 11, 2025 · NCT06856694

A Phase 1/2a Study of DB-1311/BNT324 in Advanced/Metastatic Solid Tumors

RecruitingPhase 1/2
  • Research Site 125, Los Angeles
  • Research Site 133, Los Angeles
  • Research Site 103, Los Angeles
Ages 18 and older · All sexes · Updated Nov 21, 2025 · NCT05914116

Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer

RecruitingPhase 3
  • Los Angeles County-USC Medical Center, Los Angeles
  • USC / Norris Comprehensive Cancer Center, Los Angeles
Ages 18 and older · Men · Updated Sep 11, 2025 · NCT03678025

A Trial of AMXI-5001 for Treatment in Patients With Advanced Malignancies

RecruitingPhase 1/2
  • University of California, Los Angles (UCLA) Department of Medicine - Hematology/Oncology, Los Angeles
Ages 18 and older · All sexes · Updated May 1, 2025 · NCT04503265

18F-Fluciclovine PET/CT Impact on Predicting Clinical Outcome of 177Lu-PSMA-617 Therapy in Patients With Prostate Cancer

RecruitingPhase 4
  • VA Greater Los Angeles Healthcare System, Los Angeles
Ages 18 and older · Men · Updated Nov 27, 2024 · NCT06706921

About Prostate Cancer

Prostate cancer is one of the most common types of cancer among American men. The risk goes up as men age. Learn about symptoms, tests, and treatment.

More about Prostate Cancer on MedlinePlus

Prostate Cancer trials in other cities

Other studies in Los Angeles

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.