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Alzheimer's Disease clinical trials in St. Louis, MO

22 studies for Alzheimer's Disease are looking for participants at sites in and around St. Louis (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Dominantly Inherited Alzheimer Network (DIAN)

RecruitingObservational studyHealthy volunteers welcome
  • Washington University in St. Louis School of Medicine, St Louis
Ages 18 and older · All sexes · Updated Oct 5, 2026 · NCT00869817

A Study of Zunveyl on Safety, Tolerability, Neuropsychiatric Symptoms, and Caregiver Distress in Alzheimer's Disease (RESOLVE)

RecruitingPhase 4
  • Tekton Research Saint Louis Psychiatry, St Louis
  • Psympatica, LLC, St Louis
Ages 50 and older · All sexes · Updated Sep 25, 2026 · NCT07633470

A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4)

RecruitingPhase 3
  • Tekton Research, LLC - Saint Louis Psychiatry - PPDS, St Louis
Ages 55 to 90 · All sexes · Updated Sep 22, 2026 · NCT06585787

Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies

RecruitingPhase 3
  • Washington University School of MedicineClinical Translational Research Unit, St Louis
Ages 50 to 90 · All sexes · Updated Sep 21, 2026 · NCT07177352

A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (ADAGIO-1)

RecruitingPhase 3
  • Local Institution - 1667, St Louis
Ages 55 to 90 · All sexes · Updated Sep 16, 2026 · NCT07011732

Study to Understand Novel Biomarkers in Researching Dementia

RecruitingObservational studyHealthy volunteers welcome
  • Washington University School of Medicine, St Louis
Ages 60 and older · All sexes · Updated Sep 11, 2026 · NCT06547099

Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant

RecruitingPhase 3
  • Washington University in St. Louis, St Louis
Ages 18 to 75 · All sexes · Updated Aug 4, 2026 · NCT06563895

Cardiac Magnetic Resonance and Echocardiography Study With Acoramidis

RecruitingPhase 4
  • Washington University in St. Louis, St Louis
Ages 18 to 80 · All sexes · Updated Jul 29, 2026 · NCT07695701

A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation

RecruitingPhase 2/3Healthy volunteers welcome
  • Washington University in St. Louis, St Louis
Ages 18 and older · All sexes · Updated Jul 27, 2026 · NCT05552157

A Study of a Potential Disease Modifying Treatment in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation

RecruitingPhase 2/3Healthy volunteers welcome
  • Washington University in St. Louis, St Louis
Ages 18 and older · All sexes · Updated Jul 27, 2026 · NCT06647498

Sleep Trial to Prevent Alzheimer's Disease

RecruitingPhase 2Healthy volunteers welcome
  • Washington University School of Medicine, St Louis
Ages 65 and older · All sexes · Updated Jul 13, 2026 · NCT04629547

DORA and LP in Alzheimer's Disease Biomarkers

RecruitingPhase 2Healthy volunteers welcome
  • Washington University in St. Louis, School of Medicine, St Louis
Ages 65 and older · All sexes · Updated Jul 13, 2026 · NCT06274528

Investigation of Inflammation in Alzheimer's Disease and Related Dementias (ADRD) Using [11C]-CS1P1

RecruitingObservational studyHealthy volunteers welcome
  • Washington University School of Medicine, St Louis
Ages 50 and older · All sexes · Updated Jun 9, 2026 · NCT06129838

Beta Amyloid PET Imaging for Alzheimer Disease With [18F]-Fluselenamyl

RecruitingObservational studyHealthy volunteers welcome
  • Washington University School of Medicine, St Louis
Ages 18 and older · All sexes · Updated Jun 9, 2026 · NCT06439992

F 18 T807 Tau PET Imaging of Alzheimer's Disease

RecruitingObservational study
  • Washington University School of Medicine, St Louis
Ages 18 and older · All sexes · Updated Jun 8, 2026 · NCT02414347

Neuroimaging in Healthy Aging and Senile Dementia (HASD_IND)

RecruitingObservational study
  • Washington University School of Medicine, St Louis
Ages 18 and older · All sexes · Updated Jun 8, 2026 · NCT04579120

Trial-Ready Cohort-Down Syndrome (TRC-DS)

RecruitingObservational study
  • Washington University, St. Louis, St Louis
Ages 25 to 55 · All sexes · Updated May 18, 2026 · NCT04165109

Late Onset Alzheimer's Disease

RecruitingObservational studyHealthy volunteers welcome
  • Joanne Norton, St Louis
Ages 55 and older · All sexes · Updated May 18, 2026 · NCT05010603

Alzheimer"s Imaging Biomarkers in Obesity

RecruitingObservational studyHealthy volunteers welcome
  • Washington University School of Medicine, St Louis
Ages 40 to 60 · All sexes · Updated May 11, 2026 · NCT05077579

Just-In-Time Adaptive Interventions (JITAIs) in a Digital Mental Health Intervention for Middle-Aged and Older Adults With Chronic Pain

Recruiting
  • Washington University in St. Louis School of Medicine, St Louis
Ages 45 and older · All sexes · Updated May 5, 2026 · NCT06978166

A Trial Evaluating the Effect of NIO752 on Tau Synthesis Measured by a Process Known as SILK

RecruitingPhase 1
  • Washington University in St. Louis, St Louis
Ages 21 to 80 · All sexes · Updated Jan 27, 2026 · NCT06372821

Imaging Biomarkers in Preclinical and Symptomatic AD

RecruitingObservational study
  • Washington University School of Medicine, St Louis
Ages 18 and older · All sexes · Updated Aug 7, 2025 · NCT04134923

About Alzheimer's Disease

Alzheimer's disease is a brain disorder that slowly destroys memory and thinking skills. It's the most common cause of dementia among older adults.

More about Alzheimer's Disease on MedlinePlus

Alzheimer's Disease trials in other cities

Other studies in St. Louis

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.