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Head and Neck Cancer clinical trials in Durham, NC

10 studies for Head and Neck Cancer are looking for participants at sites in and around Durham (within about 30 miles). Open a study to see who can join and how to contact the study team.

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The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2
  • Duke University, Durham
Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750

FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC

RecruitingPhase 2/3
  • Site#0118, Durham
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06788990

DESTINY-PANTUMOUR04

RecruitingObservational study
  • Research Site, Durham
Ages 18 to 130 · All sexes · Updated Sep 25, 2026 · NCT07124000

Autologous CAR-T Cells Targeting CSPG4 in Relapsed/Refractory HNSCC

RecruitingPhase 1
  • Lineberger Comprehensive Cancer Center at University of North Carolina Chapel Hill, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT06096038

Effects of Infusion Timing on Treatment Response in Solid Tumors

RecruitingPhase 2
  • University of North Carolina at Chapel Hill, Department of Radiation Oncology, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT07630168

Circulating Tumor DNA (ctDNA) in Locally Advanced Head and Neck Squamous Cell Carcinoma

RecruitingObservational study
  • University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Feb 6, 2026 · NCT04099290

Sparing Parotid Ducts Via MRI Sialography for Reduced Patient-Reported Xerostomia

RecruitingPhase 2
  • University of North Carolina at Chapel Hill, Department of Radiation Oncology, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Feb 3, 2026 · NCT07278557

X-ray Psoralen Activated Cancer Therapy in Head and Neck, Breast, Sarcoma and Melanoma

RecruitingPhase 1
  • Duke University, Durham
Ages 18 and older · All sexes · Updated Jan 30, 2026 · NCT04389281

Multi-Site Trial of Navigation vs Treatment as Usual to Improve Initiation of Timely Adjuvant Therapy

Recruiting
  • Duke University Medical Center, Durham
Ages 18 and older · All sexes · Updated Dec 11, 2025 · NCT05793151

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Chapel Hill · 10 mi away
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

About Head and Neck Cancer

Head and neck cancer includes cancers of the mouth, nose, sinuses, salivary glands, throat, and lymph nodes. Read the different symptoms of each type.

More about Head and Neck Cancer on MedlinePlus

Head and Neck Cancer trials in other cities

Other studies in Durham

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.