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Ovarian Cancer clinical trials in Cleveland, OH

30 studies for Ovarian Cancer are looking for participants at sites in and around Cleveland (within about 30 miles). Open a study to see who can join and how to contact the study team.

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The Vanguard Study: Testing a New Way to Screen for Cancer

RecruitingHealthy volunteers welcome
  • Louis Stokes Cleveland VA Medical Center, Cleveland
Ages 45 to 75 · All sexes · Updated Oct 5, 2026 · NCT06995898

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

RecruitingPhase 2
  • Case Western Reserve University, Cleveland
  • UHHS-Chagrin Highlands Medical Center, Beachwood · 10 mi away
  • UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor · 22 mi away
All ages · All sexes · Updated Oct 5, 2026 · NCT05564377

A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

RecruitingPhase 1
  • University Hospitals Cleveland Medical Center, Cleveland
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06465069

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2
  • The Cleveland Clinic Taussig Cancer Center, Cleveland
Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750

A Study to Assess Change in Disease Activity and Adverse Events in Adult Participants With Gynecologic Cancers Receiving Intravenous Infusion of IMGN151 as Monotherapy or in Combination With Other Therapies

RecruitingPhase 2
  • University Hospitals Cleveland Medical Center /ID# 279601, Cleveland
Ages 18 and older · Women · Updated Oct 1, 2026 · NCT07024784

Torvutatug Samrotecan Plus Bevacizumab as First-line Maintenance in Homologous Recombination Deficiency (HRD) Negative Advanced Epithelial Ovarian Cancer

RecruitingPhase 3
  • Research Site, Cleveland
Ages 18 and older · Women · Updated Oct 1, 2026 · NCT07851025

Leveraging Methylated DNA Markers (MDMs) in the Detection of Endometrial Cancer, Ovarian Cancer, and Cervical Cancer

RecruitingObservational study
  • Cleveland Clinic, Cleveland
Ages 18 and older · Women · Updated Sep 29, 2026 · NCT05051722

A Study to Assess Anti-Tumor Activity of Intravenously (IV) Infused Carboplatin With Mirvetuximab Soravtansine in Participants With Newly Diagnosed Folate Receptor Alpha (FRα)Expressing Advanced-Stage Serous Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer.

RecruitingPhase 2
  • Metrohealth Medical Center - Cleveland /ID# 276664, Cleveland
  • Cleveland Clinic - Cleveland /ID# 276133, Cleveland
  • Cleveland Clinic - Cleveland /ID# 278273, Cleveland
  • and 1 more
Ages 18 and older · Women · Updated Sep 29, 2026 · NCT06890338

Study of AVZO-021 in Patients With Advanced Solid Tumors

RecruitingPhase 1/2
  • Avenzo Therapeutics Recruiting Site, Cleveland
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT05867251

A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer

RecruitingPhase 3
  • University Hospitals Cleveland Medical Center, Cleveland
  • Fairview Hospital, Cleveland
  • Cleveland Clinic, Cleveland
  • and 1 more
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07213804

A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations

RecruitingPhase 1/2
  • UH Cleveland Medical Center, Cleveland
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07109726

Study to Evaluate INCB123667 Versus Investigator's Choice of Chemotherapy in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression

RecruitingPhase 3
  • Cleveland Clinic Foundation, Cleveland
Ages 18 and older · Women · Updated Sep 15, 2026 · NCT07214779

ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation

RecruitingObservational study
  • Cleveland Clinic, Cleveland
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT05059444

Minimally Invasive Surgery After Neoadjuvant Chemotherapy for the Treatment of Stage IIIC-IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer, LANCE Trial

RecruitingPhase 3
  • Cleveland Clinic, Cleveland
Ages 18 and older · Women · Updated Sep 14, 2026 · NCT04575935

A Phase 1 Study of LNCB74 in Advanced Solid Tumors

RecruitingPhase 1
  • Cleveland Clinic Taussig Cancer Institute, Cleveland
Ages 18 and older · All sexes · Updated Aug 21, 2026 · NCT06774963

A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer

Recruiting
  • Case Western Reserve University, Cleveland
  • MetroHealth Medical Center, Cleveland
  • Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland
  • and 4 more
Ages 35 to 50 · Women · Updated Aug 7, 2026 · NCT04251052

Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancer

RecruitingPhase 3
  • Case Western Reserve University, Cleveland
  • Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland
  • Cleveland Clinic Foundation, Cleveland
  • and 3 more
Ages 18 and older · All sexes · Updated Aug 7, 2026 · NCT06580314

Study Evaluating the Safety and Efficacy of HWK-007, a PTK7-directed Antibody Drug Conjugate in Participants With Advanced Solid Tumors

RecruitingPhase 1
  • University Hospital - Cleveland Medical Center, Cleveland
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT07444814

Gleolan for Visualization of Newly Diagnosed or Recurrent Ovarian Cancer (OVA-302)

RecruitingPhase 3
  • The Cleveland Clinic Foundation, Cleveland
Ages 18 and older · Women · Updated Jul 14, 2026 · NCT05804370

First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • UH Cleveland Medical Center, Cleveland
Ages 18 and older · All sexes · Updated Jul 7, 2026 · NCT05768139

JAB-30355 in Patients With Advanced Solid Tumors Harboring TP53 Y220C Mutation

RecruitingPhase 1/2
  • Research site, Cleveland
Ages 18 and older · All sexes · Updated May 22, 2026 · NCT06386146

Heated Intraperitoneal Chemotherapy Followed by Niraparib for Ovarian, Primary Peritoneal and Fallopian Tube Cancer

RecruitingPhase 3
  • University Hospitals Cleveland Medical Center, Cleveland
  • Cleveland Clinic, Cleveland
  • UH Minoff Health Center at Chagrin Highlands, Orange · 12 mi away
  • and 1 more
Ages 18 and older · Women · Updated Apr 16, 2026 · NCT05659381

Real World Treatment Experience of Patients With Breast, Lung, Ovarian, Multiple Myeloma, or Acute Myelogenous Leukemia Using Remote Symptom Monitoring

RecruitingObservational study
  • University Hospitals Seidman Cancer Center, Cleveland
Ages 18 and older · All sexes · Updated Feb 23, 2026 · NCT05974150

First in Human Study of TORL-1-23 in Participants With Advanced Cancer

RecruitingPhase 1
  • Cleveland Clinic, Cleveland
Ages 18 and older · All sexes · Updated Feb 13, 2026 · NCT05103683

cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

RecruitingObservational studyHealthy volunteers welcome
  • Cleveland Clinic, Cleveland
Ages 40 and older · All sexes · Updated Jan 20, 2026 · NCT05366881

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Mayfield Heights · 12 mi away
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

A Phase 1 Study of XL309 (ISM3091) Alone and in Combination in Participants With Advanced Solid Tumors

RecruitingPhase 1
  • Exelixis Clinical Site #7, Cleveland
Ages 18 and older · All sexes · Updated Sep 5, 2025 · NCT05932862

Regorafenib Combined With Fulvestrant in Recurrent Low-Grade Serous Ovarian Cancer

RecruitingPhase 2
  • University Hospitals Cleveland Medical Center, Seidman Cancer Center, Case Comprehensive Cancer Center, Cleveland
Ages 18 and older · Women · Updated Aug 21, 2025 · NCT05113368

About Ovarian Cancer

Ovarian cancer is a cancerous tumor that forms in the tissues of an ovary. The ovaries are a pair of female reproductive glands that make eggs and female hormones.

More about Ovarian Cancer on MedlinePlus

Ovarian Cancer trials in other cities

Other studies in Cleveland

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.