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Sickle Cell Disease clinical trials in Greenville, NC

9 studies for Sickle Cell Disease are looking for participants at sites in and around Greenville (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

A Phase 1b, Open-Label Study of DISC-3405 in Participants With Sickle Cell Disease (SCD)

RecruitingPhase 1
  • Brody School of Medicine at East Carolina University, Greenville
Ages 18 and older · All sexes · Updated Oct 5, 2026 · NCT07187973

A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease

RecruitingPhase 3
  • East Carolina Univ-Greenville, Greenville
Ages 12 and older · All sexes · Updated Sep 17, 2026 · NCT06612268

A Phase I/II Study of ITU512 in Healthy Participants and Patients With Sickle Cell Disease

RecruitingPhase 1/2Healthy volunteers welcome
  • East Carolina University, Greenville
Ages 12 to 55 · All sexes · Updated Sep 9, 2026 · NCT06546670

A Phase 2/3 Study of Osivelotor in Adult and Adolescent Participants With SCD

RecruitingPhase 2/3
  • ECU Physicians, Brody Outpatient Clinic, Greenville
Ages 12 and older · All sexes · Updated Aug 18, 2026 · NCT05431088

A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease

RecruitingPhase 1/2Healthy volunteers welcome
  • Local Institution - 0033, Greenville
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT06481306

ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders

RecruitingObservational study
  • East Carolina University Hemophilia Treatment Center, Greenville
All ages · All sexes · Updated Aug 17, 2026 · NCT04398628

Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis

RecruitingPhase 2
  • East Carolina University, Greenville
Ages 12 and older · All sexes · Updated Aug 14, 2026 · NCT06699849

Peer Support for Adolescents and Emerging Adults With Sickle Cell Pain

Recruiting
  • East Carolina University Health Medical Center, Greenville
Ages 16 to 30 · All sexes · Updated Jan 7, 2026 · NCT06374238

About Sickle Cell Disease

Sickle cell disease is a group of inherited disorders that affect your red blood cells. It can cause pain, anemia, and other problems. Learn about treatments.

More about Sickle Cell Disease on MedlinePlus

Sickle Cell Disease trials in other cities

Other studies in Greenville

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.