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Breast Cancer clinical trials in Irvine, CA
23 studies for Breast Cancer are looking for participants at sites in and around Irvine (within about 30 miles). Open a study to see who can join and how to contact the study team.
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A Study of Alisertib in Combination With Endocrine Therapy in Patients With HR-positive, HER2-negative Recurrent or Metastatic Breast Cancer
RecruitingPhase 2
- City of Hope at Orange County Lennar Foundation Cancer Center, Irvine
Abemaciclib and Endocrine Therapy in Older Patients With Breast Cancer.
RecruitingPhase 2
- City of Hope at Irvine Lennar, Irvine
A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)
RecruitingPhase 3
- Chao Family Comprehensive Cancer Center and Ambulatory Care (CIACC) - Irvine, Irvine
- City of Hope Orange County Lennar Foundation Cancer Center, Irvine
A Study of Imlunestrant (LY3484356) in Premenopausal Women With Estrogen Receptor-Positive (ER+) Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Early Breast Cancer
RecruitingPhase 2
- City of Hope Orange County Lennar Foundation Cancer Center, Irvine
A Study to Evaluate the Efficacy and Safety of Inavolisib in Combination With Phesgo Versus Placebo in Combination With Phesgo in Participants With PIK3CA-Mutated HER2-Positive Locally Advanced or Metastatic Breast Cancer
RecruitingPhase 3
- City of Hope at Irvine Lennar, Irvine
Women Informed to Screen Depending on Measures of Risk (Wisdom Study)
RecruitingHealthy volunteers welcome
- University of California Irvine, Irvine
A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations
RecruitingPhase 1/2
- City of Hope, Irvine, Irvine
A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence
RecruitingPhase 3
- City of Hope at Irvine Lennar, Irvine
A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancer
RecruitingPhase 1/2
- City of Hope - Orange County Lennar Foundation Cancer Center, Irvine
A Study to Evaluate the Effect of GDC-4198 Alone and in Combination With Giredestrant Versus Abemaciclib and Giredestrant in Participants With Locally Advanced or Metastatic Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor-Negative (HER2-) Breast Cancer
RecruitingPhase 1/2
- City of Hope - Orange County Lennar Foundation Cancer Center, Irvine
Study of ORIC-114 in Patients With Advanced Solid Tumors Harboring an EGFR or HER2 Alteration
RecruitingPhase 1/2
- City of Hope, Irvine
A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer
RecruitingPhase 3
- City of Hope - Lennar Foundation Cancer Center, Irvine
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
RecruitingPhase 3
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine
- Kaiser Permanente-Irvine, Irvine
Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer.
RecruitingPhase 3
- Hoag Hospital Center, Irvine
- Hoag Hospital Irvine, Irvine
A Blended e-Health Intervention to Improve Fear of Progression in Women With Gynecologic or Breast Cancer
Recruiting
- City of Hope at Irvine Lennar, Irvine
Phase 3 Study to Evaluate the Efficacy and Safety of HER2/Neu Peptide GLSI-100 (GP2 + GM-CSF) in HER2/Neu Positive Subjects
RecruitingPhase 3
- City of Hope - Orange County Lennar Foundation Cancer Center, Irvine
E-Mindfulness Approaches for Living After Breast Cancer
RecruitingPhase 3
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine
- Kaiser Permanente-Irvine, Irvine
De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)
RecruitingPhase 3
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine
Photon Craniospinal Irradiation for the Treatment of Leptomeningeal Disease Secondary to Breast Cancer or Non-small Cell Lung Cancer
RecruitingPhase 2
- City of Hope at Irvine Lennar, Irvine
Phytocannabinoids for Reducing Chronic Chemotherapy-Induced Peripheral Neuropathy in Breast and Colon Cancer Survivors
RecruitingPhase 2
- City of Hope at Irvine Lennar, Irvine
Ultra-hypofractionated Whole Breast Irradiation With Lumpectomy Cavity Boost for the Treatment of Stage I-III Breast Cancer
RecruitingPhase 2
- City of Hope at Irvine Lennar, Irvine
SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
RecruitingObservational study
- Massive Bio SYNERGY-AI site, Irvine
Stereotactic Body Radiation Therapy and FES PET/CT Imaging for the Treatment of Oligoprogressive Estrogen Receptor Positive Metastatic Breast Cancer
RecruitingPhase 2
- City of Hope at Irvine Lennar, Irvine
About Breast Cancer
Breast cancer is a cancer that starts in the breast tissue, when cells change and grow out of control. These extra cells can form a mass called a tumor.
More about Breast Cancer on MedlinePlus
Breast Cancer trials in other cities
- New York City, NY134 studies
- Houston, TX126 studies
- Boston, MA111 studies
- Nashville, TN80 studies
- Los Angeles, CA72 studies
- Edison, NJ68 studies
- St. Louis, MO64 studies
- Durham, NC63 studies
- Queens, NY63 studies
- Chicago, IL58 studies
- Philadelphia, PA56 studies
- Dallas, TX55 studies
Other studies in Irvine
- Non-Small Cell Lung Cancer25 studies
- Cancer (all types)16 studies
- Metastatic Cancer16 studies
- Lung Cancer15 studies
- Multiple Myeloma14 studies
- Prostate Cancer14 studies
- Ovarian Cancer12 studies
- Alzheimer's Disease11 studies
- Head and Neck Squamous Cell Carcinoma11 studies
- Bladder Cancer11 studies
- Colorectal Cancer10 studies
- Pancreatic Cancer10 studies
From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.