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Brain Tumors clinical trials in Cleveland, OH

11 studies for Brain Tumors are looking for participants at sites in and around Cleveland (within about 30 miles). Open a study to see who can join and how to contact the study team.

Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII

RecruitingPhase 2
  • Cleveland Clinic Taussig Cancer Center, Cleveland
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07326566

Memory Avoidance Whole Brain Radiotherapy vs Hippocampal Avoidance Whole Brain Radiotherapy (Athena 2 Trial)

RecruitingPhase 2
  • University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center, Cleveland
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07248228

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

RecruitingPhase 1/2
  • Cleveland Clinic, Cleveland
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT05786924

A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases

RecruitingPhase 2
  • Case Western Reserve University, Cleveland
  • UHHS-Chagrin Highlands Medical Center, Beachwood · 10 mi away
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT04511013

Development of MRF for Characterization of Brain Tumors After Radiotherapy

RecruitingHealthy volunteers welcome
  • University Hospitals Cleveland Medical Center, Case Comprehensive Cancer Center, Cleveland
  • Cleveland Clinic Taussig Cancer Center, Cleveland
Ages 18 to 60 · All sexes · Updated Sep 15, 2026 · NCT06101069

A Phase 1/1b Study of IAM1363 in HER2 Cancers

RecruitingPhase 1
  • University Hospital Cleveland Medical Center, Cleveland
  • Cleveland Clinic, Cleveland
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06253871

Neoadjuvant Radiosurgery for Resectable Brain Metastases: Phase I/II Study

RecruitingPhase 1/2
  • Cleveland Clinic, Case Comprehensive Cancer Center, Cleveland
Ages 18 and older · All sexes · Updated Aug 6, 2026 · NCT01891318

A Phase 2 and Pharmacodynamic Study of Sitagliptin in Patients With Progressive Grade 4 Gliomas

RecruitingPhase 2
  • Case Comprehensive Cancer Center, Cleveland Clinic Foundation Taussig Cancer Institute, Cleveland
Ages 18 and older · All sexes · Updated Aug 6, 2026 · NCT07003542

REMASTer: REcurrent Brain Metastases After SRS Trial

Recruiting
  • Cleveland Clinic, Cleveland
Ages 18 and older · All sexes · Updated Jun 18, 2026 · NCT05124912

cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

RecruitingObservational studyHealthy volunteers welcome
  • Cleveland Clinic, Cleveland
Ages 40 and older · All sexes · Updated Jan 20, 2026 · NCT05366881

S1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk of Cardiac Toxicity

RecruitingPhase 3
  • Case Western Reserve University, Cleveland
  • Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland
  • Cleveland Clinic Foundation, Cleveland
  • and 3 more
Ages 18 and older · All sexes · Updated Oct 8, 2025 · NCT03418961

About Brain Tumors

A brain tumor is a growth of abnormal cells in the brain tissue. Learn the types of tumors, symptoms, how they are diagnosed and treatment options.

More about Brain Tumors on MedlinePlus

Brain Tumors trials in other cities

Other studies in Cleveland

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.