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Major Depressive Disorder clinical trials in Rochester, MN

4 studies for Major Depressive Disorder are looking for participants at sites in and around Rochester (within about 30 miles). Open a study to see who can join and how to contact the study team.

A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive Disorder

RecruitingPhase 3
  • Mayo Clinic, Rochester
Ages 12 to 17 · All sexes · Updated Sep 25, 2026 · NCT07227454

Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

Recruiting
  • Mayo Clinic, Rochester
Ages 22 to 70 · All sexes · Updated Aug 28, 2026 · NCT06423430

Identifying Cerebral Hemodynamic Patterns in Mood Disorders and Mild Cognitive Impairment: A Functional Near-Infrared Spectroscopy (fNIRS) Study

RecruitingObservational study
  • Mayo Clinic, Rochester
Ages 18 and older · All sexes · Updated Apr 29, 2026 · NCT06897670

Intravenous Ketamine for Treatment-Resistant Depression

RecruitingPhase 2
  • Mayo Clinic in Rochester, Rochester
Ages 18 to 65 · All sexes · Updated Oct 14, 2025 · NCT06668571

Major Depressive Disorder trials in other cities

Other studies in Rochester

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.